Symbols / CRBU $2.36 +4.89% Caribou Biosciences, Inc.

Healthcare • Biotechnology • United States • NMS
CRBU Chart
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About

Caribou Biosciences, Inc. operates as a clinical-stage clustered regularly interspaced short palindromic repeats (CRISPR) genome-editing biopharmaceutical company. It offers a genome-editing platform based on novel CRISPR hybrid RNA-DNA genome-editing technology that enables precise genome editing of allogeneic cell therapies. The company develops Vispacabtagene Regedleucel, an allogeneic anti-CD19 CAR-T cell therapy that is in phase 1 clinical trial to treat relapsed or refractory B cell non-Hodgkin lymphoma; and CB-011, an allogeneic anti-BCMA CAR-T cell therapy that is in phase 1 clinical trial for the treatment of relapsed or refractory multiple myeloma. Caribou Biosciences, Inc. was incorporated in 2011 and is headquartered in Berkeley, California.

Fundamentals
Scroll to Statements
Market Cap 228.06M Enterprise Value 115.95M Income -148.12M Sales 11.16M Book/sh 1.28 Cash/sh 1.44
Dividend Yield — Payout 0.00% Employees 97 IPO — P/E — Forward P/E -1.57
PEG — P/S 20.44 P/B 1.84 P/C — EV/EBITDA -0.89 EV/Sales 10.39
Quick Ratio 5.60 Current Ratio 5.71 Debt/Eq 22.29 LT Debt/Eq — EPS (ttm) -1.59 EPS next Y -1.50
EPS Growth — Revenue Growth 89.70% Earnings 2026-05-07 ROA -34.26% ROE -78.97% ROIC —
Gross Margin 0.00% Oper. Margin -7.22% Profit Margin 0.00% Shs Outstand 96.64M Shs Float 92.27M Short Float 7.00%
Short Ratio 5.81 Short Interest — 52W High 3.54 52W Low 0.73 Beta 2.46 Avg Volume 1.30M
Volume 1.42M Target Price $11.12 Recom None Prev Close $2.25 Price $2.36 Change 4.89%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$11.13
Mean price target
2. Current target
$2.36
Latest analyst target
3. DCF / Fair value
$-13.00
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$2.36
Low
$4.00
High
$32.00
Mean
$11.13

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-04-07 reit HC Wainwright & Co. Buy → Buy $9
2026-03-09 main Evercore ISI Group Outperform → Outperform $13
2026-02-02 init Clear Street — → Buy $13
2025-11-05 main HC Wainwright & Co. Buy → Buy $9
2025-11-03 main Citigroup Buy → Buy $8
2025-04-28 main HC Wainwright & Co. Buy → Buy $3
2025-03-19 reit HC Wainwright & Co. Buy → Buy $9
2025-01-07 main B of A Securities Buy → Buy $11
2024-11-26 main Citigroup Buy → Buy $6
2024-11-15 reit HC Wainwright & Co. Buy → Buy $9
2024-09-03 reit HC Wainwright & Co. Buy → Buy $9
2024-08-14 reit HC Wainwright & Co. Buy → Buy $9
2024-08-07 reit RBC Capital Outperform → Outperform $14
2024-07-17 reit HC Wainwright & Co. Buy → Buy $9
2024-06-04 main HC Wainwright & Co. Buy → Buy $9
2024-05-16 main Truist Securities Buy → Buy $19
2024-05-13 reit HC Wainwright & Co. Buy → Buy $24
2024-03-19 main HC Wainwright & Co. Buy → Buy $24
2024-03-12 reit RBC Capital Outperform → Outperform $19
2023-11-08 init Cantor Fitzgerald — → Neutral —
News
RSS: Latest CRBU news
Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2026-02-25 KELLY TIMOTHY P Chief Technology Officer — 6,228 $1.93 $12,020
2026-02-24 KHAN RUHI AHMAD Officer — 6,938 $1.96 $13,598
2026-02-24 ALBERTSON TINA M. Officer — 1,066 $1.96 $2,089
2026-02-24 MCCLUNG BARBARA G Officer — 6,938 $1.96 $13,598
2026-02-24 KELLY TIMOTHY P Chief Technology Officer — 3,147 $1.96 $6,168
2026-02-20 KHAN RUHI AHMAD Officer — 45,000 $0.00 $0
2026-02-20 ALBERTSON TINA M. Officer — 55,000 $0.00 $0
2026-02-20 MCCLUNG BARBARA G Officer — 45,000 $0.00 $0
2026-02-20 HAURWITZ RACHEL E. PH.D. Chief Executive Officer — 151,700 $0.00 $0
2026-02-20 KELLY TIMOTHY P Chief Technology Officer — 45,000 $0.00 $0
Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
11.16
+11.66%
9.99
-71.01%
34.48
+148.91%
13.85
Operating Revenue
11.16
+11.66%
9.99
-71.01%
34.48
+148.91%
13.85
Operating Expense
147.35
-16.57%
176.61
+17.32%
150.54
+25.19%
120.25
Research And Development
109.44
-15.92%
130.15
+16.13%
112.08
+36.29%
82.23
Selling General And Administration
37.91
-18.39%
46.46
+20.79%
38.46
+1.16%
38.02
General And Administrative Expense
37.91
-18.39%
46.46
+20.79%
38.46
+1.16%
38.02
Other Gand A
37.91
-18.39%
46.46
+20.79%
38.46
+1.16%
38.02
Total Expenses
147.35
-16.57%
176.61
+17.32%
150.54
+25.19%
120.25
Operating Income
-136.19
+18.26%
-166.62
-43.56%
-116.06
-9.08%
-106.40
Total Operating Income As Reported
-148.34
+10.97%
-166.62
-43.56%
-116.06
-9.08%
-106.40
EBITDA
-132.55
+18.53%
-162.69
-44.57%
-112.53
-7.40%
-104.78
Normalized EBITDA
-111.24
+31.62%
-162.69
-44.57%
-112.53
-7.54%
-104.64
Reconciled Depreciation
3.65
-7.18%
3.93
+11.40%
3.52
+117.32%
1.62
EBIT
-136.19
+18.26%
-166.62
-43.56%
-116.06
-9.08%
-106.40
Total Unusual Items
-21.31
0.00
+100.00%
-0.01
+95.49%
-0.13
Total Unusual Items Excluding Goodwill
-21.31
0.00
+100.00%
-0.01
+95.49%
-0.13
Special Income Charges
-21.31
0.00
—
0.00
Other Special Charges
—
—
—
—
Write Off
21.31
0.00
—
—
Net Income
-148.12
+0.66%
-149.10
-46.08%
-102.07
-2.66%
-99.42
Pretax Income
-148.68
+0.29%
-149.11
-46.37%
-101.88
-2.54%
-99.35
Net Non Operating Interest Income Expense
—
—
—
—
Interest Expense Non Operating
—
—
—
—
Net Interest Income
—
—
—
—
Interest Expense
—
—
—
—
Interest Income Non Operating
—
—
—
—
Interest Income
—
—
—
—
Other Income Expense
-12.48
-171.31%
17.50
+23.41%
14.18
+101.22%
7.05
Other Non Operating Income Expenses
8.83
-49.57%
17.50
+23.41%
14.18
+97.49%
7.18
Gain On Sale Of Security
—
—
-0.01
+95.49%
-0.13
Tax Provision
-0.55
-6011.11%
-0.01
-104.66%
0.19
+175.71%
0.07
Tax Rate For Calcs
0.00
0.00
0.00
-100.00%
0.00
Tax Effect Of Unusual Items
-0.09
0.00
0.00
+100.00%
-0.03
Net Income Including Noncontrolling Interests
-148.12
+0.66%
-149.10
-46.08%
-102.07
-2.66%
-99.42
Net Income From Continuing Operation Net Minority Interest
-148.12
+0.66%
-149.10
-46.08%
-102.07
-2.66%
-99.42
Net Income From Continuing And Discontinued Operation
-148.12
+0.66%
-149.10
-46.08%
-102.07
-2.66%
-99.42
Net Income Continuous Operations
-148.12
+0.66%
-149.10
-46.08%
-102.07
-2.66%
-99.42
Normalized Income
-126.90
+14.89%
-149.10
-46.08%
-102.07
-2.77%
-99.32
Net Income Common Stockholders
-148.12
+0.66%
-149.10
-46.08%
-102.07
-2.66%
-99.42
Diluted EPS
-1.59
+3.64%
-1.65
-19.57%
-1.38
+15.85%
-1.64
Basic EPS
-1.59
+3.64%
-1.65
-19.57%
-1.38
+15.85%
-1.64
Basic Average Shares
93.39
+3.40%
90.32
+22.37%
73.81
+21.39%
60.80
Diluted Average Shares
93.39
+3.40%
90.32
+22.37%
73.81
+21.39%
60.80
Diluted NI Availto Com Stockholders
-148.12
+0.66%
-149.10
-46.08%
-102.07
-2.66%
-99.42
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Assets
175.37
-44.03%
313.31
-27.51%
432.21
+15.64%
373.76
Current Assets
145.23
-33.80%
219.38
-35.26%
338.84
+30.20%
260.25
Cash Cash Equivalents And Short Term Investments
139.34
-33.50%
209.54
-36.28%
328.83
+32.77%
247.66
Cash And Cash Equivalents
12.36
-24.14%
16.29
-68.15%
51.16
-12.30%
58.34
Cash Equivalents
12.36
-24.14%
16.29
-68.15%
51.16
-12.30%
58.34
Other Short Term Investments
126.98
-34.29%
193.24
-30.40%
277.67
+46.66%
189.32
Receivables
2.98
-8.37%
3.25
-15.76%
3.86
-17.26%
4.66
Accounts Receivable
0.07
-73.96%
0.27
+79.05%
0.15
-26.73%
0.20
Other Receivables
2.91
-2.55%
2.99
-0.76%
3.01
-22.69%
3.89
Accrued Interest Receivable
—
0.93
+32.48%
0.70
+23.16%
0.57
Prepaid Assets
2.91
-55.79%
6.59
+33.52%
4.93
-27.45%
6.80
Other Current Assets
—
1.78
+45.98%
1.22
+9.03%
1.12
Total Non Current Assets
30.14
-67.92%
93.94
+0.61%
93.37
-17.75%
113.52
Net PPE
24.43
-37.82%
39.29
-2.87%
40.45
+15.88%
34.91
Gross PPE
37.96
-27.25%
52.17
+5.20%
49.60
+22.29%
40.56
Accumulated Depreciation
-13.53
-4.98%
-12.88
-40.91%
-9.14
-61.87%
-5.65
Properties
0.00
0.00
0.00
0.00
Machinery Furniture Equipment
1.59
+0.00%
1.59
+14.35%
1.39
+60.23%
0.87
Construction In Progress
—
0.00
-100.00%
8.20
+726.18%
0.99
Other Properties
33.31
-14.74%
39.06
+3.44%
37.76
+2.57%
36.82
Leases
3.06
-73.46%
11.52
+415.35%
2.23
+19.14%
1.88
Investments And Advances
3.50
-92.87%
49.12
-4.30%
51.33
-33.40%
77.07
Other Non Current Assets
2.20
-60.15%
5.52
+248.11%
1.59
+3.12%
1.54
Total Liabilities Net Minority Interest
53.19
-11.88%
60.36
-5.40%
63.81
-12.46%
72.89
Current Liabilities
25.41
-17.09%
30.65
+8.30%
28.30
+0.62%
28.13
Payables And Accrued Expenses
13.76
-13.24%
15.86
+16.32%
13.63
+34.93%
10.10
Payables
5.78
+133.56%
2.48
-20.64%
3.12
+172.25%
1.15
Accounts Payable
5.78
+133.56%
2.48
-20.64%
3.12
+172.25%
1.15
Current Accrued Expenses
7.97
-40.41%
13.38
+27.29%
10.51
+17.36%
8.96
Pensionand Other Post Retirement Benefit Plans Current
7.75
-9.52%
8.56
-10.06%
9.52
+65.46%
5.75
Current Debt And Capital Lease Obligation
1.20
-15.78%
1.43
+18.83%
1.20
+24.22%
0.97
Current Capital Lease Obligation
1.20
-15.78%
1.43
+18.83%
1.20
+24.22%
0.97
Current Deferred Liabilities
1.90
-39.44%
3.13
+9.91%
2.85
-71.35%
9.94
Current Deferred Revenue
1.90
-39.44%
3.13
+9.91%
2.85
-71.35%
9.94
Other Current Liabilities
0.82
-51.40%
1.68
+51.81%
1.11
-19.27%
1.37
Total Non Current Liabilities Net Minority Interest
27.78
-6.51%
29.71
-16.32%
35.51
-20.69%
44.77
Long Term Debt And Capital Lease Obligation
26.03
+3.85%
25.06
-3.27%
25.91
-3.26%
26.78
Long Term Capital Lease Obligation
26.03
+3.85%
25.06
-3.27%
25.91
-3.26%
26.78
Non Current Deferred Liabilities
1.75
-54.67%
3.87
-41.96%
6.66
-59.23%
16.34
Non Current Deferred Revenue
1.75
-47.18%
3.32
-45.64%
6.10
-61.75%
15.95
Non Current Deferred Taxes Liabilities
0.00
-100.00%
0.55
-1.62%
0.56
+46.19%
0.38
Other Non Current Liabilities
—
0.79
-73.29%
2.94
+78.01%
1.65
Stockholders Equity
122.17
-51.70%
252.95
-31.34%
368.40
+22.44%
300.87
Common Stock Equity
122.17
-51.70%
252.95
-31.34%
368.40
+22.44%
300.87
Capital Stock
0.01
+0.00%
0.01
+12.50%
0.01
+33.33%
0.01
Common Stock
0.01
+0.00%
0.01
+12.50%
0.01
+33.33%
0.01
Preferred Stock
—
—
—
0.00
Share Issued
95.14
+2.99%
92.38
+4.44%
88.45
+44.93%
61.03
Ordinary Shares Number
95.14
+2.99%
92.38
+4.44%
88.45
+44.93%
61.03
Additional Paid In Capital
718.58
+2.50%
701.08
+5.01%
667.65
+33.64%
499.60
Retained Earnings
-596.51
-33.03%
-448.39
-49.82%
-299.29
-51.76%
-197.22
Gains Losses Not Affecting Retained Earnings
0.10
-59.61%
0.26
+750.00%
0.03
+101.98%
-1.52
Total Equity Gross Minority Interest
122.17
-51.70%
252.95
-31.34%
368.40
+22.44%
300.87
Total Capitalization
122.17
-51.70%
252.95
-31.34%
368.40
+22.44%
300.87
Working Capital
119.82
-36.51%
188.73
-39.23%
310.54
+33.78%
232.12
Invested Capital
122.17
-51.70%
252.95
-31.34%
368.40
+22.44%
300.87
Total Debt
27.23
+2.79%
26.49
-2.29%
27.11
-2.30%
27.75
Capital Lease Obligations
27.23
+2.79%
26.49
-2.29%
27.11
-2.30%
27.75
Net Tangible Assets
122.17
-51.70%
252.95
-31.34%
368.40
+22.44%
300.87
Tangible Book Value
122.17
-51.70%
252.95
-31.34%
368.40
+22.44%
300.87
Available For Sale Securities
3.50
-92.87%
49.12
-4.30%
51.33
-33.40%
77.07
Investmentin Financial Assets
3.50
-92.87%
49.12
-4.30%
51.33
-33.40%
77.07
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
-110.99
+19.69%
-138.20
-48.14%
-93.29
-2.56%
-90.97
Cash Flow From Continuing Operating Activities
-110.99
+19.69%
-138.20
-48.14%
-93.29
-2.56%
-90.97
Net Income From Continuing Operations
-148.12
+0.66%
-149.10
-46.08%
-102.07
-2.66%
-99.42
Depreciation Amortization Depletion
3.65
-7.18%
3.93
+11.40%
3.52
+117.32%
1.62
Depreciation
3.65
-7.18%
3.93
—
—
Depreciation And Amortization
3.65
-7.18%
3.93
+11.40%
3.52
+117.32%
1.62
Other Non Cash Items
1.05
+10400.00%
0.01
-99.69%
3.27
+21933.33%
-0.01
Stock Based Compensation
12.68
-24.10%
16.71
+21.50%
13.75
+17.36%
11.72
Asset Impairment Charge
21.31
0.00
—
—
Operating Gains Losses
-0.03
-177.78%
-0.01
+73.53%
-0.03
—
Unrealized Gain Loss On Investment Securities
0.10
-10.81%
0.11
+1750.00%
0.01
-95.49%
0.13
Gain Loss On Sale Of PPE
-0.03
-177.78%
-0.01
+73.53%
-0.03
0.00
Change In Working Capital
-0.48
+90.54%
-5.11
+30.12%
-7.32
-74.07%
-4.20
Change In Receivables
0.27
-55.26%
0.61
-24.47%
0.81
-76.73%
3.46
Changes In Account Receivables
0.20
+267.52%
-0.12
-316.67%
0.05
-94.32%
0.95
Change In Prepaid Assets
3.67
+948.73%
-0.43
-124.52%
1.77
+281.13%
-0.97
Change In Payables And Accrued Expense
-3.09
-273.37%
1.78
-76.46%
7.56
+1084.64%
-0.77
Change In Accrued Expense
-6.34
-397.09%
2.13
-62.84%
5.74
+194.06%
1.95
Change In Payable
3.25
+1019.21%
-0.35
-119.46%
1.82
+166.85%
-2.72
Change In Account Payable
3.25
+1019.21%
-0.35
-119.46%
1.82
+166.85%
-2.72
Change In Other Working Capital
-3.35
-33.15%
-2.51
+85.01%
-16.77
-239.46%
-4.94
Change In Other Current Assets
3.35
+185.13%
-3.94
-8097.92%
-0.05
+91.49%
-0.56
Change In Other Current Liabilities
-1.35
-117.23%
-0.62
+2.51%
-0.64
-52.39%
-0.42
Investing Cash Flow
102.24
+18.05%
86.61
+227.02%
-68.18
+26.88%
-93.25
Cash Flow From Continuing Investing Activities
102.24
+18.05%
86.61
+227.02%
-68.18
+26.88%
-93.25
Net PPE Purchase And Sale
-1.36
+72.08%
-4.87
+58.09%
-11.61
-79.93%
-6.45
Purchase Of PPE
-1.36
+72.15%
-4.88
+57.98%
-11.61
-79.93%
-6.45
Sale Of PPE
0.00
-100.00%
0.01
0.00
—
Capital Expenditure
-1.36
+79.11%
-6.50
+43.99%
-11.61
-64.63%
-7.05
Net Investment Purchase And Sale
103.60
+11.28%
93.10
+264.57%
-56.57
+34.37%
-86.19
Purchase Of Investment
-149.23
+50.97%
-304.39
+22.89%
-394.76
-16.43%
-339.06
Sale Of Investment
252.83
-36.39%
397.49
+17.54%
338.19
+33.74%
252.87
Net Intangibles Purchase And Sale
0.00
+100.00%
-1.62
0.00
+100.00%
-0.60
Purchase Of Intangibles
0.00
+100.00%
-1.62
0.00
+100.00%
-0.60
Financing Cash Flow
4.82
-71.17%
16.72
-89.16%
154.30
+7133.85%
2.13
Cash Flow From Continuing Financing Activities
4.82
-71.17%
16.72
-89.16%
154.30
+7133.85%
2.13
Net Issuance Payments Of Debt
—
—
—
0.00
Issuance Of Debt
—
—
—
0.00
Repayment Of Debt
—
—
—
0.00
Long Term Debt Issuance
—
—
—
0.00
Long Term Debt Payments
—
—
—
0.00
Net Long Term Debt Issuance
—
—
—
0.00
Net Common Stock Issuance
4.07
-73.21%
15.19
-90.05%
152.72
0.00
Proceeds From Stock Option Exercised
0.75
-50.98%
1.53
-2.92%
1.58
-26.02%
2.13
Changes In Cash
-3.93
+88.72%
-34.87
-385.91%
-7.18
+96.06%
-182.08
Beginning Cash Position
16.34
-68.09%
51.21
-12.29%
58.38
-75.72%
240.47
End Cash Position
12.41
-24.07%
16.34
-68.09%
51.21
-12.29%
58.38
Free Cash Flow
-112.35
+22.36%
-144.71
-37.94%
-104.90
-7.02%
-98.02
Income Tax Paid Supplemental Data
—
0.00
-100.00%
0.17
0.00
Amortization Of Securities
-1.14
+75.88%
-4.73
-6.80%
-4.42
-455.21%
-0.80
Common Stock Issuance
4.07
-73.21%
15.19
-90.05%
152.72
0.00
Issuance Of Capital Stock
4.07
-73.21%
15.19
-90.05%
152.72
0.00
Net Preferred Stock Issuance
—
—
—
0.00
Preferred Stock Issuance
—
—
—
0.00
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

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