Symbols / NUVL Stock $108.02 -0.76% Nuvalent, Inc.

Healthcare • Biotechnology • United States • NMS
NUVL (Stock) Chart
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About

Nuvalent, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for patients with cancer. Its lead product candidates are Zidesamtinib (NVL-520), a novel ROS1-selective inhibitor to address the clinical challenges of emergent treatment resistance, central nervous system (CNS)-related adverse events, and brain metastases that may limit the use of ROS1 tyrosine kinase inhibitors (TKIs) for patients with ROS proto-oncogene 1 (ROS1)-positive non-small cell lung cancer (NSCLC) which is under the Phase 2 portion of the ARROS-1 Phase 1/2 clinical trial; Neladalkib (NVL-655), a brain-penetrant ALK-selective inhibitor, to address the clinical challenges of emergent treatment resistance, CNS-related adverse events, and brain metastases that might limit the use of first-, second-, and third-generation ALK inhibitors that is under the Phase 2 portion of the ALKOVE-1 clinical trial; and NVL-330, a brain-penetrant human epidermal growth factor receptor 2 (HER2)-selective inhibitor designed to treat tumors driven by HER2ex20, brain metastases, and avoiding treatment-limiting adverse events including due to off-target inhibition of wild-type EGFR that is in Phase 1a/1b clinical trial. The company was incorporated in 2017 and is headquartered in Cambridge, Massachusetts.

Stock Fundamentals
Scroll to Statements
Market Cap 8.49B Enterprise Value 7.19B Income -425.38M Sales — Book/sh 15.96 Cash/sh 17.45
Dividend Yield — Payout 0.00% Employees 228 IPO — P/E — Forward P/E -26.77
PEG — P/S — P/B 6.77 P/C — EV/EBITDA — EV/Sales —
Quick Ratio 15.05 Current Ratio 15.27 Debt/Eq — LT Debt/Eq — EPS (ttm) -5.85 EPS next Y -4.04
EPS Growth — Revenue Growth — Earnings 2026-05-07 ROA -20.27% ROE -36.70% ROIC —
Gross Margin 0.00% Oper. Margin 0.00% Profit Margin 0.00% Shs Outstand 73.18M Shs Float 48.68M Short Float 13.26%
Short Ratio 8.80 Short Interest — 52W High 113.02 52W Low 63.55 Beta 1.31 Avg Volume 550.42K
Volume 905.01K Target Price $142.37 Recom Strong_buy Prev Close $108.85 Price $108.02 Change -0.76%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$142.37
Mean price target
2. Current target
$108.02
Latest analyst target
3. DCF / Fair value
$-34.83
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$108.02
Low
$116.00
High
$165.00
Mean
$142.37

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-04-21 reit HC Wainwright & Co. Buy → Buy $155
2026-04-08 reit Wedbush Outperform → Outperform $125
2026-03-30 init Wells Fargo — → Overweight $116
2026-02-27 main Cantor Fitzgerald Overweight → Overweight $140
2025-12-19 main JP Morgan Overweight → Overweight $145
2025-11-24 init Truist Securities — → Buy $140
2025-11-18 main Goldman Sachs Buy → Buy $135
2025-11-18 main Baird Outperform → Outperform $158
2025-11-18 main Guggenheim Buy → Buy $155
2025-11-17 main Stifel Buy → Buy $135
2025-11-17 main Leerink Partners Outperform → Outperform $149
2025-11-17 main HC Wainwright & Co. Buy → Buy $155
2025-11-12 init Canaccord Genuity — → Buy $126
2025-10-31 main Barclays Overweight → Overweight $112
2025-10-31 main UBS Buy → Buy $132
2025-10-27 main Piper Sandler Overweight → Overweight $128
2025-10-15 init Cantor Fitzgerald — → Overweight $135
2025-09-08 reit Wedbush Outperform → Outperform $115
2025-09-03 init Raymond James — → Outperform $105
2025-08-19 init Piper Sandler — → Overweight $112
News
RSS: Latest NUVL news
Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2026-04-09 PELISH HENRY E Officer — 3,093 $104.27 $323,164
2026-04-09 PELISH HENRY E Officer — 3,093 $27.85 $86,140
2026-04-06 PORTER JAMES RICHARD Chief Executive Officer — 30,000 $103.21 $3,113,231
2026-04-06 PORTER JAMES RICHARD Chief Executive Officer — 30,000 $18.93 $713,171
2026-04-01 BALCOM ALEXANDRA Chief Financial Officer — 11,430 $104.39 $1,202,527
2026-04-01 BALCOM ALEXANDRA Chief Financial Officer — 11,430 $1.08 $12,344
2026-04-01 LANE BENJAMIN Chief Operating Officer — 9,500 $0.00 $0
2026-03-30 NOCI DARLENE Officer — 5,500 $97.43 $537,943
2026-03-30 NOCI DARLENE Officer — 5,500 $27.85 $153,175
2026-03-26 MILLER DEBORAH ANN Officer — 5,500 $97.50 $542,991
Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
0.00
0.00
0.00
0.00
Operating Revenue
0.00
0.00
0.00
0.00
Operating Expense
414.31
+47.77%
280.37
+87.55%
149.49
+73.61%
86.11
Research And Development
306.97
+40.96%
217.77
+92.31%
113.24
+77.69%
63.73
Selling General And Administration
107.34
+71.48%
62.59
+72.68%
36.25
+61.99%
22.38
General And Administrative Expense
107.34
+71.48%
62.59
+72.68%
36.25
+61.99%
22.38
Salaries And Wages
63.68
+51.23%
42.11
+82.37%
23.09
+87.46%
12.32
Other Gand A
15.03
+38.50%
10.85
+68.99%
6.42
-71.30%
22.38
Total Expenses
414.31
+47.77%
280.37
+87.55%
149.49
+73.61%
86.11
Operating Income
-414.31
-47.77%
-280.37
-87.55%
-149.49
-73.61%
-86.11
Total Operating Income As Reported
-414.31
-47.77%
-280.37
-87.55%
-149.49
-73.61%
-86.11
EBITDA
-414.31
-47.77%
-280.37
-87.55%
-149.49
-73.61%
-86.11
Normalized EBITDA
-414.31
-47.77%
-280.37
-87.55%
-149.49
-73.61%
-86.11
EBIT
-414.31
-47.77%
-280.37
-87.55%
-149.49
-73.61%
-86.11
Net Income
-425.38
-63.13%
-260.76
-106.59%
-126.22
-54.20%
-81.85
Pretax Income
-424.79
-63.39%
-259.99
-105.98%
-126.22
-54.20%
-81.85
Net Non Operating Interest Income Expense
44.73
+16.75%
38.32
+64.64%
23.27
+447.09%
4.25
Net Interest Income
44.73
+16.75%
38.32
+64.64%
23.27
+447.09%
4.25
Interest Income Non Operating
44.73
+16.75%
38.32
+64.64%
23.27
+447.09%
4.25
Interest Income
44.73
+16.75%
38.32
+64.64%
23.27
+447.09%
4.25
Other Income Expense
-55.22
-207.80%
-17.94
—
4.25
Other Non Operating Income Expenses
-55.22
-207.80%
-17.94
—
4.25
Tax Provision
0.58
-23.43%
0.76
0.00
0.00
Tax Rate For Calcs
0.00
+0.00%
0.00
0.00
0.00
Tax Effect Of Unusual Items
0.00
0.00
0.00
0.00
Net Income Including Noncontrolling Interests
-425.38
-63.13%
-260.76
-106.59%
-126.22
-54.20%
-81.85
Net Income From Continuing Operation Net Minority Interest
-425.38
-63.13%
-260.76
-106.59%
-126.22
-54.20%
-81.85
Net Income From Continuing And Discontinued Operation
-425.38
-63.13%
-260.76
-106.59%
-126.22
-54.20%
-81.85
Net Income Continuous Operations
-425.38
-63.13%
-260.76
-106.59%
-126.22
-54.20%
-81.85
Normalized Income
-425.38
-63.13%
-260.76
-106.59%
-126.22
-54.20%
-81.85
Net Income Common Stockholders
-425.38
-63.13%
-260.76
-106.59%
-126.22
-54.20%
-81.85
Diluted EPS
—
-3.93
-81.11%
-2.17
-31.52%
-1.65
Basic EPS
—
-3.93
-81.11%
-2.17
-31.52%
-1.65
Basic Average Shares
—
66.41
+14.06%
58.22
+17.22%
49.67
Diluted Average Shares
—
66.41
+14.06%
58.22
+17.22%
49.67
Diluted NI Availto Com Stockholders
-425.38
-63.13%
-260.76
-106.59%
-126.22
-54.20%
-81.85
Insurance And Claims
28.63
+197.14%
9.63
+42.98%
6.74
+23.36%
5.46
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Assets
1,412.70
+23.73%
1,141.75
+55.90%
732.38
+51.80%
482.46
Current Assets
1,392.43
+22.96%
1,132.45
+55.88%
726.49
+51.99%
477.99
Cash Cash Equivalents And Short Term Investments
1,371.95
+22.68%
1,118.30
+55.34%
719.90
+52.47%
472.16
Cash And Cash Equivalents
261.75
+79.66%
145.69
-56.56%
335.39
+38.70%
241.81
Other Short Term Investments
1,110.21
+14.15%
972.61
+152.94%
384.52
+66.92%
230.36
Prepaid Assets
—
—
—
—
Other Current Assets
20.47
+44.73%
14.15
+114.89%
6.58
+12.95%
5.83
Total Non Current Assets
20.28
+117.96%
9.30
+57.80%
5.90
+31.96%
4.47
Other Non Current Assets
20.28
+117.96%
9.30
+57.80%
5.90
+31.96%
4.47
Total Liabilities Net Minority Interest
164.37
+128.41%
71.96
+126.13%
31.82
+63.35%
19.48
Current Liabilities
91.17
+68.77%
54.02
+69.75%
31.82
+63.35%
19.48
Payables And Accrued Expenses
74.24
+70.39%
43.57
+77.85%
24.50
+67.46%
14.63
Payables
30.16
+477.19%
5.22
-43.66%
9.27
+28.90%
7.20
Accounts Payable
30.16
+477.19%
5.22
-43.66%
9.27
+28.90%
7.20
Current Accrued Expenses
44.08
+14.96%
38.34
+151.88%
15.22
+104.78%
7.43
Pensionand Other Post Retirement Benefit Plans Current
16.93
+62.03%
10.45
+42.67%
7.33
+50.99%
4.85
Total Non Current Liabilities Net Minority Interest
73.19
+308.00%
17.94
0.00
0.00
Tradeand Other Payables Non Current
0.00
0.00
0.00
—
Other Non Current Liabilities
0.04
—
—
—
Stockholders Equity
1,248.34
+16.69%
1,069.79
+52.71%
700.56
+51.32%
462.98
Common Stock Equity
1,248.34
+16.69%
1,069.79
+52.71%
700.56
+51.32%
462.98
Capital Stock
0.01
+0.00%
0.01
+14.29%
0.01
+16.67%
0.01
Common Stock
0.01
+0.00%
0.01
+14.29%
0.01
+16.67%
0.01
Preferred Stock
0.00
0.00
0.00
0.00
Share Issued
78.24
+9.66%
71.34
+11.36%
64.07
+13.05%
56.67
Ordinary Shares Number
78.24
+9.66%
71.34
+11.36%
64.07
+13.05%
56.67
Additional Paid In Capital
2,218.41
+37.20%
1,616.89
+63.85%
986.82
+58.26%
623.54
Retained Earnings
-972.43
-77.76%
-547.05
-91.08%
-286.30
-78.85%
-160.08
Gains Losses Not Affecting Retained Earnings
2.35
+4088.14%
-0.06
-290.32%
0.03
+106.28%
-0.49
Other Equity Adjustments
2.35
+4088.14%
-0.06
-290.32%
0.03
+106.28%
-0.49
Total Equity Gross Minority Interest
1,248.34
+16.69%
1,069.79
+52.71%
700.56
+51.32%
462.98
Total Capitalization
1,248.34
+16.69%
1,069.79
+52.71%
700.56
+51.32%
462.98
Working Capital
1,301.26
+20.66%
1,078.43
+55.24%
694.66
+51.50%
458.51
Invested Capital
1,248.34
+16.69%
1,069.79
+52.71%
700.56
+51.32%
462.98
Net Tangible Assets
1,248.34
+16.69%
1,069.79
+52.71%
700.56
+51.32%
462.98
Tangible Book Value
1,248.34
+16.69%
1,069.79
+52.71%
700.56
+51.32%
462.98
Dueto Related Parties Non Current
73.16
+307.80%
17.94
0.00
—
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
-275.21
-48.71%
-185.06
-85.55%
-99.74
-53.51%
-64.97
Cash Flow From Continuing Operating Activities
-275.21
-48.71%
-185.06
-85.55%
-99.74
-53.51%
-64.97
Net Income From Continuing Operations
-425.38
-63.13%
-260.76
-106.59%
-126.22
-54.20%
-81.85
Other Non Cash Items
44.46
+1259.16%
3.27
+132.36%
-10.11
-2610.19%
-0.37
Stock Based Compensation
86.50
+42.79%
60.58
+136.98%
25.56
+147.58%
10.32
Change In Working Capital
19.21
+62.20%
11.84
+7.40%
11.03
+59.08%
6.93
Change In Prepaid Assets
-6.34
+16.14%
-7.56
-1274.38%
0.64
+143.19%
-1.49
Change In Payables And Accrued Expense
36.06
+58.06%
22.81
+93.17%
11.81
+21.83%
9.69
Change In Accrued Expense
11.46
-57.34%
26.86
+178.62%
9.64
+75.87%
5.48
Change In Payable
24.60
+707.53%
-4.05
-286.68%
2.17
-48.50%
4.21
Change In Account Payable
24.60
+707.53%
-4.05
-286.68%
2.17
-48.50%
4.21
Change In Other Current Assets
-10.51
-208.33%
-3.41
-138.66%
-1.43
-12.26%
-1.27
Investing Cash Flow
-124.08
+78.37%
-573.51
-299.59%
-143.53
-1245.78%
-10.66
Cash Flow From Continuing Investing Activities
-124.08
+78.37%
-573.51
-299.59%
-143.53
-1245.78%
-10.66
Net Investment Purchase And Sale
-124.08
+78.37%
-573.51
-299.59%
-143.53
-1245.78%
-10.66
Purchase Of Investment
-1,057.77
-3.20%
-1,024.96
-123.07%
-459.49
-115.81%
-212.92
Sale Of Investment
933.69
+106.82%
451.45
+42.88%
315.96
+56.22%
202.25
Financing Cash Flow
515.34
-9.41%
568.88
+68.88%
336.85
+35.33%
248.92
Cash Flow From Continuing Financing Activities
515.34
-9.41%
568.88
+68.88%
336.85
+35.33%
248.92
Net Issuance Payments Of Debt
—
—
—
0.00
Issuance Of Debt
—
—
—
0.00
Long Term Debt Issuance
—
—
—
0.00
Net Long Term Debt Issuance
—
—
—
0.00
Net Common Stock Issuance
515.72
-9.52%
569.99
+68.40%
338.48
+35.14%
250.47
Proceeds From Stock Option Exercised
—
—
14.18
+670.65%
1.84
Net Other Financing Charges
-0.38
+65.43%
-1.10
+32.33%
-1.63
-5.08%
-1.55
Changes In Cash
116.05
+161.18%
-189.70
-302.71%
93.58
-45.99%
173.28
Beginning Cash Position
145.69
-56.56%
335.39
+38.70%
241.81
+252.87%
68.53
End Cash Position
261.75
+79.66%
145.69
-56.56%
335.39
+38.70%
241.81
Free Cash Flow
-275.21
-48.71%
-185.06
-85.55%
-99.74
-53.51%
-64.97
Amortization Of Securities
—
—
-10.11
-2610.19%
-0.37
Common Stock Issuance
515.72
-9.52%
569.99
+68.40%
338.48
+35.14%
250.47
Issuance Of Capital Stock
515.72
-9.52%
569.99
+68.40%
338.48
+35.14%
250.47
Net Preferred Stock Issuance
—
—
—
0.00
Preferred Stock Issuance
—
—
—
0.00
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

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