Symbols / SLN Stock $7.84 -1.63% Silence Therapeutics plc

Healthcare • Biotechnology • United Kingdom • NGM
SLN (Stock) Chart
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About

Silence Therapeutics plc, a biotechnology company, engages in the discovery and development of novel molecules incorporating short interfering ribonucleic acid (siRNA) to inhibit the expression of specific target genes in hematology, cardiovascular, and rare diseases. The company develops Divesiran (SLN124), which is in Phase 2 development for polycythemia vera, and SLN548 for complement-mediated renal diseases. It also develops Zerlasiran (SLN360) for cardiovascular disease associated with elevated lipoprotein(a); SLN312 for dyslipidemia; SLN365 for hypercholesterolemia; and SLN098 for obesity. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc was incorporated in 1994 and is headquartered in London, United Kingdom.

Stock Fundamentals
Scroll to Statements
Market Cap 370.31M Enterprise Value 1.04B Income -88.61M Sales 559.00K Book/sh 1.32 Cash/sh 0.60
Dividend Yield — Payout 0.00% Employees 88 IPO — P/E — Forward P/E -10.89
PEG — P/S 662.46 P/B 5.94 P/C — EV/EBITDA -12.78 EV/Sales 1868.35
Quick Ratio 8.06 Current Ratio 8.72 Debt/Eq 0.26 LT Debt/Eq — EPS (ttm) -1.89 EPS next Y -0.72
EPS Growth — Revenue Growth -99.90% Earnings 2026-05-07 ROA -30.79% ROE -90.27% ROIC —
Gross Margin 61.54% Oper. Margin -371.50% Profit Margin 0.00% Shs Outstand 47.23M Shs Float 74.75M Short Float 4.91%
Short Ratio 4.99 Short Interest — 52W High 8.40 52W Low 3.08 Beta 1.33 Avg Volume 308.92K
Volume 510.33K Target Price $32.80 Recom None Prev Close $7.97 Price $7.84 Change -1.63%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$32.80
Mean price target
2. Current target
$7.84
Latest analyst target
3. DCF / Fair value
$-15.07
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$7.84
Low
$4.00
High
$75.00
Mean
$32.80

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-03-13 reit HC Wainwright & Co. Buy → Buy $75
2025-09-16 reit HC Wainwright & Co. Buy → Buy $75
2025-08-08 main Chardan Capital Buy → Buy $35
2025-06-13 reit HC Wainwright & Co. Buy → Buy $75
2025-06-13 main Chardan Capital Buy → Buy $35
2025-05-09 main Goldman Sachs Sell → Sell $3
2025-05-09 main Morgan Stanley Overweight → Overweight $25
2025-05-09 main Chardan Capital Buy → Buy $35
2025-03-07 reit HC Wainwright & Co. Buy → Buy $75
2025-03-05 main Morgan Stanley Overweight → Overweight $45
2025-03-04 main BMO Capital Outperform → Outperform $25
2025-03-04 main Goldman Sachs Sell → Sell $4
2025-02-11 init Goldman Sachs — → Sell $6
2025-02-03 reit HC Wainwright & Co. Buy → Buy $75
2025-01-29 reit HC Wainwright & Co. Buy → Buy $75
2024-12-10 main Chardan Capital Buy → Buy $55
2024-12-09 reit HC Wainwright & Co. Buy → Buy $75
2024-11-20 reit HC Wainwright & Co. Buy → Buy $75
2024-11-15 reit HC Wainwright & Co. Buy → Buy $75
2024-11-14 main Chardan Capital Buy → Buy $55
News
RSS: Latest SLN news
Insider Transactions

No recent insider transactions.

Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
0.56
-98.71%
43.26
+36.71%
31.64
+46.12%
21.66
Operating Revenue
0.56
-98.71%
43.26
+36.71%
31.64
+46.12%
21.66
Cost Of Revenue
0.21
-98.18%
11.81
-8.21%
12.87
-4.43%
13.46
Reconciled Cost Of Revenue
0.21
-98.18%
11.81
-8.21%
12.87
-4.43%
13.46
Gross Profit
0.34
-98.91%
31.45
+67.49%
18.78
+129.20%
8.19
Operating Expense
90.10
-4.93%
94.77
+13.96%
83.16
+20.12%
69.23
Research And Development
67.75
-0.19%
67.88
+19.22%
56.94
+30.74%
43.55
Selling General And Administration
22.34
-16.89%
26.88
+2.52%
26.22
+2.10%
25.68
General And Administrative Expense
22.34
-16.89%
26.88
+2.52%
26.22
+2.10%
25.68
Other Gand A
22.34
-16.89%
26.88
+2.52%
26.22
+2.10%
25.68
Other Operating Expenses
—
-13.74
-14.96%
-11.95
-21.68%
-9.82
Total Expenses
90.31
-15.26%
106.58
+10.99%
96.03
+16.12%
82.69
Operating Income
-89.75
-41.75%
-63.32
+1.65%
-64.38
-5.48%
-61.04
Total Operating Income As Reported
-91.08
-43.84%
-63.32
+1.65%
-64.38
-5.48%
-61.04
EBITDA
-89.20
-42.20%
-62.73
+1.62%
-63.76
-5.49%
-60.44
Normalized EBITDA
-79.41
-25.30%
-63.37
-3.68%
-61.12
+1.00%
-61.74
Reconciled Depreciation
0.56
-6.41%
0.59
-4.51%
0.62
+4.19%
0.60
EBIT
-89.75
-41.75%
-63.32
+1.65%
-64.38
-5.48%
-61.04
Total Unusual Items
-9.79
-1615.63%
0.65
+124.46%
-2.64
-304.10%
1.29
Total Unusual Items Excluding Goodwill
-9.79
-1615.63%
0.65
+124.46%
-2.64
-304.10%
1.29
Special Income Charges
-1.32
0.00
—
—
Restructuring And Mergern Acquisition
1.32
0.00
—
—
Net Income
-88.61
-95.57%
-45.31
+16.45%
-54.23
-7.74%
-50.33
Pretax Income
-88.60
-99.26%
-44.46
+16.53%
-53.27
-7.30%
-49.65
Net Non Operating Interest Income Expense
3.48
-22.18%
4.47
+148.03%
1.80
+543.93%
0.28
Interest Expense Non Operating
—
—
0.04
-23.85%
0.06
Net Interest Income
3.48
-22.18%
4.47
+148.03%
1.80
+543.93%
0.28
Interest Expense
—
—
0.04
-23.85%
0.06
Interest Income Non Operating
3.48
-22.18%
4.47
+148.03%
1.80
+543.93%
0.28
Interest Income
3.48
-22.18%
4.47
+148.03%
1.80
+543.93%
0.28
Other Income Expense
-2.33
-116.19%
14.38
+54.52%
9.31
-16.25%
11.11
Other Non Operating Income Expenses
7.46
-45.67%
13.74
+14.96%
11.95
+21.68%
9.82
Gain On Sale Of Security
-8.47
-1410.68%
0.65
+124.46%
-2.64
-304.10%
1.29
Tax Provision
0.01
-98.70%
0.84
-11.61%
0.96
+38.95%
0.69
Tax Rate For Calcs
0.00
+0.00%
0.00
+31.58%
0.00
+0.00%
0.00
Tax Effect Of Unusual Items
-2.45
-1615.63%
0.16
+132.18%
-0.50
-304.10%
0.25
Net Income Including Noncontrolling Interests
-88.61
-95.57%
-45.31
+16.45%
-54.23
-7.74%
-50.33
Net Income From Continuing Operation Net Minority Interest
-88.61
-95.57%
-45.31
+16.45%
-54.23
-7.74%
-50.33
Net Income From Continuing And Discontinued Operation
-88.61
-95.57%
-45.31
+16.45%
-54.23
-7.74%
-50.33
Net Income Continuous Operations
-88.61
-95.57%
-45.31
+16.45%
-54.23
-7.74%
-50.33
Normalized Income
-81.27
-77.47%
-45.79
+12.09%
-52.09
-1.38%
-51.38
Net Income Common Stockholders
-88.61
-95.57%
-45.31
+16.45%
-54.23
-7.74%
-50.33
Diluted EPS
-1.89
-90.91%
-0.99
+32.65%
-1.47
+5.77%
-1.56
Basic EPS
-1.89
-90.91%
-0.99
+32.65%
-1.47
+5.77%
-1.56
Basic Average Shares
47.23
+2.12%
46.25
+24.69%
37.09
+15.21%
32.19
Diluted Average Shares
47.23
+2.12%
46.25
+24.69%
37.09
+15.21%
32.19
Diluted NI Availto Com Stockholders
-88.61
-95.57%
-45.31
+16.45%
-54.23
-7.74%
-50.33
Other Taxes
—
-13.74
-14.96%
-11.95
-21.68%
-9.82
Rent Expense Supplemental
—
—
—
0.41
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Assets
131.44
-35.13%
202.63
+69.64%
119.45
-8.19%
130.10
Current Assets
118.66
-36.67%
187.37
+81.64%
103.15
-11.84%
117.01
Cash Cash Equivalents And Short Term Investments
85.11
-42.23%
147.33
+114.18%
68.79
-20.10%
86.10
Cash And Cash Equivalents
11.28
-90.71%
121.33
+76.38%
68.79
+3.69%
66.34
Cash Equivalents
0.00
-100.00%
64.74
+75.11%
36.97
+138.10%
15.53
Cash Financial
11.28
-80.07%
56.59
+77.85%
31.82
-37.38%
50.81
Other Short Term Investments
73.84
+183.94%
26.00
0.00
-100.00%
19.76
Receivables
24.61
-8.53%
26.91
+12.22%
23.98
+14.25%
20.99
Accounts Receivable
0.00
-100.00%
0.97
+235.17%
0.29
-73.81%
1.11
Other Receivables
22.01
-9.79%
24.40
+8.71%
22.44
—
Taxes Receivable
2.61
+69.29%
1.54
+23.69%
1.25
-93.74%
19.88
Prepaid Assets
8.93
-31.96%
13.12
+26.37%
10.38
+4.65%
9.92
Total Non Current Assets
12.78
-16.27%
15.27
-6.31%
16.30
+24.53%
13.09
Net PPE
1.75
-25.01%
2.33
-12.70%
2.67
+0.24%
2.66
Gross PPE
5.71
-16.73%
6.86
-4.35%
7.17
+8.00%
6.64
Accumulated Depreciation
-3.96
+12.46%
-4.53
-0.60%
-4.50
-13.21%
-3.97
Machinery Furniture Equipment
5.54
-12.63%
6.34
-1.44%
6.44
+6.66%
6.03
Construction In Progress
0.00
-100.00%
0.36
-1.66%
0.36
—
Other Properties
0.17
+6.37%
0.16
-57.57%
0.37
-38.61%
0.60
Goodwill And Other Intangible Assets
10.91
+12.42%
9.70
-6.18%
10.34
+2.61%
10.08
Goodwill
10.62
+13.09%
9.39
-5.90%
9.98
+2.98%
9.69
Other Intangible Assets
0.29
-7.69%
0.31
-13.81%
0.36
-6.52%
0.39
Investments And Advances
—
—
0.36
+5.26%
0.34
Non Current Prepaid Assets
0.13
-96.07%
3.23
-1.52%
3.28
0.00
Total Liabilities Net Minority Interest
69.14
+0.77%
68.61
-29.60%
97.45
-5.74%
103.38
Current Liabilities
13.61
-19.08%
16.82
-24.69%
22.34
-15.89%
26.56
Payables And Accrued Expenses
10.39
-19.78%
12.95
+4.44%
12.40
-18.87%
15.29
Payables
4.64
+1.09%
4.59
+0.81%
4.56
-11.25%
5.13
Accounts Payable
4.41
+19.26%
3.70
+10.42%
3.35
-13.17%
3.86
Current Accrued Expenses
5.75
-31.24%
8.36
+6.55%
7.85
-22.73%
10.15
Pensionand Other Post Retirement Benefit Plans Current
2.96
-13.96%
3.44
+9.92%
3.13
—
Total Tax Payable
0.23
-73.88%
0.90
-25.83%
1.21
-5.48%
1.28
Income Tax Payable
0.04
-94.02%
0.65
+37.55%
0.47
-33.50%
0.71
Current Debt And Capital Lease Obligation
0.09
-23.93%
0.12
-48.68%
0.23
-57.76%
0.54
Current Capital Lease Obligation
0.09
-23.93%
0.12
-48.68%
0.23
-57.76%
0.54
Current Deferred Liabilities
0.17
-45.10%
0.31
-95.34%
6.57
-38.74%
10.73
Current Deferred Revenue
0.17
-45.10%
0.31
-95.34%
6.57
-38.74%
10.73
Total Non Current Liabilities Net Minority Interest
55.52
+7.21%
51.79
-31.06%
75.12
-2.23%
76.83
Long Term Debt And Capital Lease Obligation
0.07
0.00
-100.00%
0.12
0.00
Long Term Capital Lease Obligation
0.07
0.00
-100.00%
0.12
0.00
Non Current Deferred Liabilities
55.45
+7.07%
51.79
-30.95%
75.00
-2.38%
76.83
Non Current Deferred Revenue
55.45
+7.07%
51.79
-30.95%
75.00
-2.38%
76.83
Stockholders Equity
62.30
-53.51%
134.02
+509.39%
21.99
-17.66%
26.71
Common Stock Equity
62.30
-53.51%
134.02
+509.39%
21.99
-17.66%
26.71
Capital Stock
10.29
+0.02%
10.29
+16.29%
8.85
+35.63%
6.52
Common Stock
10.29
+0.02%
10.29
+16.29%
8.85
+35.63%
6.52
Share Issued
141.70
+0.02%
141.67
+19.21%
118.85
+10.24%
107.81
Ordinary Shares Number
141.70
+0.02%
141.67
+19.21%
118.85
+10.24%
107.81
Additional Paid In Capital
617.56
+1.31%
609.56
+33.74%
455.76
+62.42%
280.60
Retained Earnings
-562.57
-18.68%
-474.04
-9.76%
-431.89
-35.56%
-318.60
Gains Losses Not Affecting Retained Earnings
-2.98
+74.74%
-11.78
-9.85%
-10.72
-136.42%
29.45
Other Equity Adjustments
-2.98
+74.74%
-11.78
-9.85%
-10.72
-139.83%
26.92
Total Equity Gross Minority Interest
62.30
-53.51%
134.02
+509.39%
21.99
-17.66%
26.71
Total Capitalization
62.30
-53.51%
134.02
+509.39%
21.99
-17.66%
26.71
Working Capital
105.05
-38.41%
170.54
+111.03%
80.81
-10.66%
90.45
Invested Capital
62.30
-53.51%
134.02
+509.39%
21.99
-17.66%
26.71
Total Debt
0.16
+36.75%
0.12
-66.18%
0.35
-35.90%
0.54
Capital Lease Obligations
0.16
+36.75%
0.12
-66.18%
0.35
-35.90%
0.54
Net Tangible Assets
51.40
-58.66%
124.32
+967.12%
11.65
-29.95%
16.63
Tangible Book Value
51.40
-58.66%
124.32
+967.12%
11.65
-29.95%
16.63
Available For Sale Securities
—
—
0.36
+5.26%
0.34
Foreign Currency Translation Adjustments
—
—
2.49
-1.50%
2.52
Investmentin Financial Assets
—
—
0.36
+5.26%
0.34
Other Equity Interest
—
—
44.43
+54.61%
28.74
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
-62.27
+7.94%
-67.64
-36.75%
-49.46
+13.29%
-57.04
Cash Flow From Continuing Operating Activities
-62.27
+7.94%
-67.64
-36.75%
-49.46
+13.29%
-57.04
Net Income From Continuing Operations
-88.61
-95.57%
-45.31
+16.45%
-54.23
-7.74%
-50.33
Depreciation Amortization Depletion
0.56
-6.41%
0.59
-4.51%
0.62
+4.19%
0.60
Depreciation
0.31
-7.14%
0.34
-8.94%
0.37
-2.64%
0.38
Amortization Cash Flow
0.24
-5.45%
0.26
+1.98%
0.25
+16.13%
0.22
Depreciation And Amortization
0.56
-6.41%
0.59
-4.51%
0.62
+4.19%
0.60
Amortization Of Intangibles
0.24
-5.45%
0.26
+1.98%
0.25
+16.13%
0.22
Other Non Cash Items
-3.48
+22.18%
-4.47
-148.03%
-1.80
-543.93%
-0.28
Stock Based Compensation
8.07
-50.49%
16.31
+0.20%
16.27
+28.28%
12.69
Deferred Tax
0.01
-98.70%
0.84
-11.61%
0.96
+38.95%
0.69
Deferred Income Tax
0.01
-98.70%
0.84
-11.61%
0.96
+38.95%
0.69
Operating Gains Losses
11.02
+527.04%
-2.58
-165.14%
3.96
+495.01%
-1.00
Net Foreign Currency Exchange Gain Loss
11.02
+527.04%
-2.58
-165.14%
3.96
+495.01%
-1.00
Gain Loss On Sale Of PPE
—
—
—
0.00
Change In Working Capital
10.16
+130.76%
-33.02
-116.63%
-15.24
+21.41%
-19.40
Change In Receivables
5.07
+256.28%
-3.24
-7.64%
-3.01
+71.44%
-10.54
Changes In Account Receivables
1.02
+213.27%
-0.90
-330.61%
0.39
+154.22%
-0.72
Change In Payables And Accrued Expense
-4.08
-917.23%
0.50
+205.50%
-0.47
-123.37%
2.02
Change In Payable
-4.08
-917.23%
0.50
+205.50%
-0.47
-123.37%
2.02
Change In Other Working Capital
-0.33
+98.84%
-28.79
-178.85%
-10.32
-89.66%
-5.44
Change In Other Current Assets
9.67
+827.37%
-1.33
-5.39%
-1.26
+75.73%
-5.20
Change In Other Current Liabilities
-0.17
-1.82%
-0.17
+5.71%
-0.17
+25.53%
-0.23
Investing Cash Flow
-47.99
-118.48%
-21.97
-213.85%
19.29
+194.13%
-20.50
Cash Flow From Continuing Investing Activities
-47.99
-118.48%
-21.97
-213.85%
19.29
+194.13%
-20.50
Net PPE Purchase And Sale
-0.06
+73.93%
-0.21
-276.79%
-0.06
+67.63%
-0.17
Purchase Of PPE
-0.06
+73.93%
-0.21
-276.79%
-0.06
+67.63%
-0.17
Sale Of PPE
—
—
—
0.00
Capital Expenditure
-0.06
+73.93%
-0.21
-276.79%
-0.06
+89.72%
-0.55
Net Investment Purchase And Sale
-47.94
-120.35%
-21.75
-212.43%
19.35
+196.98%
-19.95
Purchase Of Investment
-166.41
-19.58%
-139.17
-440.01%
-25.77
-29.16%
-19.95
Sale Of Investment
118.48
+0.91%
117.41
+160.22%
45.12
0.00
Net Intangibles Purchase And Sale
—
0.00
0.00
+100.00%
-0.37
Purchase Of Intangibles
—
0.00
0.00
+100.00%
-0.37
Financing Cash Flow
0.01
-99.99%
142.09
+344.90%
31.94
-39.26%
52.58
Cash Flow From Continuing Financing Activities
0.01
-99.99%
142.09
+344.90%
31.94
-39.26%
52.58
Net Issuance Payments Of Debt
—
—
-0.22
+3.60%
-0.23
Repayment Of Debt
—
—
-0.22
+3.60%
-0.23
Long Term Debt Payments
—
—
-0.22
+3.60%
-0.23
Net Long Term Debt Issuance
—
—
-0.22
+3.60%
-0.23
Net Common Stock Issuance
0.01
-99.99%
142.09
+344.90%
31.94
-39.26%
52.58
Changes In Cash
-110.25
-310.07%
52.48
+2866.70%
1.77
+107.09%
-24.96
Effect Of Exchange Rate Changes
0.20
+225.00%
0.06
-91.99%
0.75
+109.23%
-8.12
Beginning Cash Position
121.33
+76.38%
68.79
+3.80%
66.27
-33.30%
99.35
End Cash Position
11.28
-90.71%
121.33
+76.38%
68.79
+3.80%
66.27
Free Cash Flow
-62.33
+8.14%
-67.85
-37.02%
-49.52
+14.01%
-57.59
Income Tax Paid Supplemental Data
0.64
+47.11%
0.43
-45.94%
0.80
0.00
Common Stock Issuance
0.01
-99.99%
142.09
+344.90%
31.94
-39.26%
52.58
Interest Received CFI
—
—
1.22
+4284.46%
0.03
Issuance Of Capital Stock
0.01
-99.99%
142.09
+344.90%
31.94
-39.26%
52.58
Taxes Refund Paid
—
—
7.91
0.00
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

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