Symbols / XENE $56.65 +0.44% Xenon Pharmaceuticals Inc.

Healthcare • Biotechnology • Canada • NGM
XENE Chart
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About

Xenon Pharmaceuticals Inc., a neuroscience-focused biopharmaceutical company, engages in the discovery, development, and delivery of therapeutics to treat patients with neurological and psychiatric disorders. Its product candidates include Azetukalner, a novel, potent Kv7 potassium channel opener which is in Phase 3 clinical development for the treatment of epilepsy, including focal onset seizures, and primary generalized tonic-clonic seizures, as well as neuropsychiatric disorders, such as major depressive disorder and bipolar depression. In addition, the company's Phase 1 Single Ascending Dose/Multiple Ascending Dose products include XEN1701 targeting the sodium channel and XEN1120 targeting the Kv7 potassium channel for the treatment of pain. The company has a license and collaboration agreement with Neurocrine Biosciences, Inc. for the development of NBI-921355, a Nav1.2/1.6 sodium channel inhibitor that is in Phase 1 clinical trials for the treatment of certain types of epilepsy. Xenon Pharmaceuticals Inc. was incorporated in 1996 and is headquartered in Burnaby, Canada.

Fundamentals
Scroll to Statements
Market Cap 5.41B Enterprise Value 4.17B Income -345.91M Sales 7.50M Book/sh 7.27 Cash/sh 6.60
Dividend Yield — Payout 0.00% Employees 358 IPO — P/E — Forward P/E -11.97
PEG — P/S 720.79 P/B 7.79 P/C — EV/EBITDA -11.26 EV/Sales 556.24
Quick Ratio 13.17 Current Ratio 13.41 Debt/Eq 1.37 LT Debt/Eq — EPS (ttm) -4.36 EPS next Y -4.73
EPS Growth — Revenue Growth — Earnings 2026-05-11 ROA -32.58% ROE -51.76% ROIC —
Gross Margin 0.00% Oper. Margin -49.74% Profit Margin 0.00% Shs Outstand 95.43M Shs Float 78.36M Short Float 5.55%
Short Ratio 2.13 Short Interest — 52W High 63.95 52W Low 28.19 Beta 0.74 Avg Volume 1.36M
Volume 703.11K Target Price $79.24 Recom Strong_buy Prev Close $56.40 Price $56.65 Change 0.44%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$79.24
Mean price target
2. Current target
$56.65
Latest analyst target
3. DCF / Fair value
$-33.03
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$56.65
Low
$58.58
High
$100.00
Mean
$79.24

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-03-16 main Wedbush Outperform → Outperform $63
2026-03-10 main Wells Fargo Overweight → Overweight $68
2026-03-10 main Wedbush Outperform → Outperform $64
2026-03-10 main Deutsche Bank Buy → Buy $90
2026-03-10 main HC Wainwright & Co. Buy → Buy $74
2026-03-09 main Needham Buy → Buy $80
2026-03-09 main Baird Outperform → Outperform $97
2026-02-27 main Needham Buy → Buy $58
2026-02-27 main Wells Fargo Overweight → Overweight $49
2026-02-24 init Wolfe Research — → Outperform $60
2026-01-09 main JP Morgan Overweight → Overweight $62
2025-12-11 main Wells Fargo Overweight → Overweight $48
2025-11-18 main JP Morgan Overweight → Overweight $60
2025-11-04 main RBC Capital Outperform → Outperform $58
2025-11-04 main Wells Fargo Overweight → Overweight $44
2025-11-04 reit Needham Buy → Buy $55
2025-10-07 main Chardan Capital Buy → Buy $55
2025-09-02 reit RBC Capital Outperform → Outperform $55
2025-08-12 main Chardan Capital Buy → Buy $55
2025-08-12 main RBC Capital Outperform → Outperform $55
News
RSS: Latest XENE news
Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2026-03-13 MORTIMER IAN C Chief Executive Officer — 7,308 $55.22 $403,584
2026-03-13 DIFABIO ANDREA Officer — 1,342 $55.22 $74,112
2026-03-13 KENNEY CHRISTOPHER JOHN Officer — 1,410 $55.22 $77,867
2026-03-12 MORTIMER IAN C Chief Executive Officer — 12,500 — —
2026-03-12 DIFABIO ANDREA Officer — 3,750 — —
2026-03-12 KENNEY CHRISTOPHER JOHN Officer — 3,750 — —
2026-03-10 MORTIMER IAN C Chief Executive Officer — 281,269 $58.81 $16,966,500
2026-03-10 DIFABIO ANDREA Officer — 2,607 $60.11 $156,702
2026-03-10 KENNEY CHRISTOPHER JOHN Officer — 2,771 $60.11 $166,559
2026-03-09 MORTIMER IAN C Chief Executive Officer — 290,000 $3.10 $1,819,850
Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
7.50
0.00
0.00
-100.00%
9.43
Operating Revenue
7.50
0.00
0.00
-100.00%
9.43
Operating Expense
380.57
+36.26%
279.30
+30.48%
214.05
+54.47%
138.58
Research And Development
300.94
+43.04%
210.39
+25.60%
167.51
+58.38%
105.77
Selling General And Administration
79.63
+15.57%
68.90
+48.05%
46.54
+41.85%
32.81
General And Administrative Expense
79.63
+15.57%
68.90
+48.05%
46.54
+41.85%
32.81
Other Gand A
79.63
+15.57%
68.90
+48.05%
46.54
+41.85%
32.81
Total Expenses
380.57
+36.26%
279.30
+30.48%
214.05
+54.47%
138.58
Operating Income
-373.07
-33.57%
-279.30
-30.48%
-214.05
-65.75%
-129.14
Total Operating Income As Reported
-373.07
-33.57%
-279.30
-30.48%
-214.05
-65.75%
-129.14
EBITDA
-370.53
-33.89%
-276.74
-30.54%
-211.99
-65.96%
-127.74
Normalized EBITDA
-371.88
-34.90%
-275.67
-27.78%
-215.74
-75.52%
-122.91
Reconciled Depreciation
2.54
-0.66%
2.56
+24.21%
2.06
+46.69%
1.41
EBIT
-373.07
-33.57%
-279.30
-30.48%
-214.05
-65.75%
-129.14
Total Unusual Items
1.35
+226.69%
-1.06
-128.38%
3.75
+177.70%
-4.83
Total Unusual Items Excluding Goodwill
1.35
+226.69%
-1.06
-128.38%
3.75
+177.70%
-4.83
Special Income Charges
—
—
—
0.00
Net Income
-345.91
-47.62%
-234.33
-28.48%
-182.39
-45.48%
-125.37
Pretax Income
-344.89
-44.66%
-238.42
-30.51%
-182.69
-45.85%
-125.25
Net Non Operating Interest Income Expense
26.83
-36.04%
41.94
+51.86%
27.62
+217.00%
8.71
Interest Expense Non Operating
—
—
—
0.00
Net Interest Income
26.83
-36.04%
41.94
+51.86%
27.62
+217.00%
8.71
Interest Expense
—
—
—
0.00
Interest Income Non Operating
26.83
-36.04%
41.94
+51.86%
27.62
+217.00%
8.71
Interest Income
26.83
-36.04%
41.94
+51.86%
27.62
+217.00%
8.71
Other Income Expense
1.35
+226.69%
-1.06
-128.38%
3.75
+177.70%
-4.83
Gain On Sale Of Security
1.35
+226.69%
-1.06
-128.38%
3.75
+177.70%
-4.83
Tax Provision
1.02
+124.85%
-4.09
-1300.34%
-0.29
-347.46%
0.12
Tax Rate For Calcs
0.00
+782.35%
0.00
+750.00%
0.00
-99.24%
0.00
Tax Effect Of Unusual Items
0.20
+1217.87%
-0.02
-341.24%
0.01
+100.59%
-1.26
Net Income Including Noncontrolling Interests
-345.91
-47.62%
-234.33
-28.48%
-182.39
-45.48%
-125.37
Net Income From Continuing Operation Net Minority Interest
-345.91
-47.62%
-234.33
-28.48%
-182.39
-45.48%
-125.37
Net Income From Continuing And Discontinued Operation
-345.91
-47.62%
-234.33
-28.48%
-182.39
-45.48%
-125.37
Net Income Continuous Operations
-345.91
-47.62%
-234.33
-28.48%
-182.39
-45.48%
-125.37
Normalized Income
-347.06
-48.77%
-233.28
-25.33%
-186.13
-52.80%
-121.81
Net Income Common Stockholders
-345.91
-47.62%
-234.33
-28.48%
-182.39
-45.99%
-124.94
Diluted EPS
-4.36
-44.85%
-3.01
-10.26%
-2.73
-32.52%
-2.06
Basic EPS
-4.36
-44.85%
-3.01
-10.26%
-2.73
-32.52%
-2.06
Basic Average Shares
79.25
+1.74%
77.89
+16.45%
66.89
+10.48%
60.54
Diluted Average Shares
79.25
+1.74%
77.89
+16.45%
66.89
+10.48%
60.54
Diluted NI Availto Com Stockholders
-345.91
-47.62%
-234.33
-28.48%
-182.39
-45.99%
-124.94
Preferred Stock Dividends
—
—
—
-0.44
Line Item Trend 2023-12-31
Total Assets
964.80
Current Assets
644.96
Cash Cash Equivalents And Short Term Investments
638.08
Cash And Cash Equivalents
148.64
Other Short Term Investments
489.44
Receivables
0.87
Accounts Receivable
0.87
Prepaid Assets
—
Other Current Assets
6.01
Total Non Current Assets
319.84
Net PPE
18.85
Gross PPE
30.10
Accumulated Depreciation
-11.25
Properties
0.00
Buildings And Improvements
9.19
Machinery Furniture Equipment
2.77
Other Properties
9.11
Leases
9.02
Investments And Advances
292.79
Non Current Deferred Assets
0.80
Non Current Deferred Taxes Assets
0.80
Non Current Prepaid Assets
7.40
Total Liabilities Net Minority Interest
36.88
Current Liabilities
27.27
Payables And Accrued Expenses
18.55
Payables
8.95
Accounts Payable
8.60
Current Accrued Expenses
9.60
Pensionand Other Post Retirement Benefit Plans Current
7.42
Total Tax Payable
0.35
Current Debt And Capital Lease Obligation
1.30
Current Capital Lease Obligation
1.30
Current Deferred Liabilities
—
Current Deferred Revenue
—
Total Non Current Liabilities Net Minority Interest
9.60
Long Term Debt And Capital Lease Obligation
9.60
Long Term Capital Lease Obligation
9.60
Other Non Current Liabilities
—
Stockholders Equity
927.92
Common Stock Equity
927.92
Capital Stock
1,436.37
Common Stock
1,436.37
Preferred Stock
—
Share Issued
75.37
Ordinary Shares Number
75.37
Treasury Shares Number
0.00
Additional Paid In Capital
156.76
Retained Earnings
-665.14
Gains Losses Not Affecting Retained Earnings
-0.08
Other Equity Adjustments
-0.08
Total Equity Gross Minority Interest
927.92
Total Capitalization
927.92
Working Capital
617.69
Invested Capital
927.92
Total Debt
10.90
Capital Lease Obligations
10.90
Net Tangible Assets
927.92
Tangible Book Value
927.92
Available For Sale Securities
292.79
Investmentin Financial Assets
292.79
Preferred Stock Equity
—
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
-279.12
-53.88%
-181.39
-20.04%
-151.11
-49.57%
-101.03
Cash Flow From Continuing Operating Activities
-279.12
-53.88%
-181.39
-20.04%
-151.11
-49.57%
-101.03
Net Income From Continuing Operations
-345.91
-47.62%
-234.33
-28.48%
-182.39
-45.48%
-125.37
Depreciation Amortization Depletion
2.54
-0.66%
2.56
+24.21%
2.06
+46.69%
1.41
Depreciation
2.54
-0.66%
2.56
+24.21%
2.06
+46.69%
1.41
Depreciation And Amortization
2.54
-0.66%
2.56
+24.21%
2.06
+46.69%
1.41
Other Non Cash Items
1.31
+4.70%
1.25
+3.38%
1.21
+48.11%
0.82
Stock Based Compensation
53.71
+5.90%
50.72
+56.67%
32.37
+58.87%
20.38
Deferred Tax
-3.20
+63.92%
-8.86
-2935.62%
-0.29
-563.64%
-0.04
Deferred Income Tax
-3.20
+63.92%
-8.86
-2935.62%
-0.29
-563.64%
-0.04
Operating Gains Losses
0.70
-6.31%
0.74
+216.41%
-0.64
-123.45%
2.73
Gain Loss On Investment Securities
0.62
—
—
2.93
Unrealized Gain Loss On Investment Securities
0.00
0.00
+100.00%
-3.55
-221.00%
2.93
Net Foreign Currency Exchange Gain Loss
0.07
-90.20%
0.74
+216.41%
-0.64
-123.45%
2.73
Change In Working Capital
4.36
-23.68%
5.71
-3.20%
5.90
+562.54%
-1.28
Change In Receivables
0.10
+116.94%
-0.61
-572.31%
0.13
-92.60%
1.76
Changes In Account Receivables
0.10
+116.94%
-0.61
-572.31%
0.13
-92.60%
1.76
Change In Prepaid Assets
-3.16
-220.83%
-0.98
-162.52%
1.57
+115.00%
-10.49
Change In Payables And Accrued Expense
5.51
-35.40%
8.53
+117.02%
3.93
-51.24%
8.06
Change In Other Working Capital
—
—
—
—
Change In Other Current Liabilities
1.90
+255.90%
-1.22
-556.93%
0.27
+144.50%
-0.60
Investing Cash Flow
218.00
+32.12%
165.00
+248.13%
-111.39
+62.04%
-293.40
Cash Flow From Continuing Investing Activities
218.00
+32.12%
165.00
+248.13%
-111.39
+62.04%
-293.40
Net PPE Purchase And Sale
-0.80
+74.02%
-3.08
+45.26%
-5.62
-94.09%
-2.89
Purchase Of PPE
-0.80
+74.02%
-3.08
+45.26%
-5.62
-94.09%
-2.89
Capital Expenditure
-0.80
+74.02%
-3.08
+45.26%
-5.62
-94.09%
-2.89
Net Investment Purchase And Sale
218.80
+30.18%
168.07
+258.91%
-105.77
+63.59%
-290.51
Purchase Of Investment
-355.66
+33.18%
-532.27
+32.96%
-793.91
-44.05%
-551.14
Sale Of Investment
574.45
-17.98%
700.34
+1.77%
688.14
+164.03%
260.63
Financing Cash Flow
117.11
+865.48%
12.13
-96.57%
353.52
+26.95%
278.47
Cash Flow From Continuing Financing Activities
117.11
+865.48%
12.13
-96.57%
353.52
+26.95%
278.47
Net Issuance Payments Of Debt
—
—
—
0.00
Repayment Of Debt
—
—
—
0.00
Long Term Debt Payments
—
—
—
0.00
Net Long Term Debt Issuance
—
—
—
0.00
Net Common Stock Issuance
112.15
+828.17%
12.08
-96.58%
353.49
+27.26%
277.77
Proceeds From Stock Option Exercised
4.96
+10457.45%
0.05
+34.29%
0.04
-95.04%
0.70
Changes In Cash
55.99
+1414.70%
-4.26
-104.68%
91.03
+178.50%
-115.96
Effect Of Exchange Rate Changes
0.46
+127.39%
-1.67
-544.68%
0.38
+115.14%
-2.48
Beginning Cash Position
142.71
-3.99%
148.64
+159.67%
57.24
-67.42%
175.69
End Cash Position
199.16
+39.56%
142.71
-3.99%
148.64
+159.67%
57.24
Free Cash Flow
-279.92
-51.75%
-184.46
-17.70%
-156.73
-50.81%
-103.92
Interest Paid Supplemental Data
—
—
—
0.00
Amortization Of Securities
7.37
+803.06%
0.82
+114.11%
-5.79
-122.67%
-2.60
Common Stock Issuance
112.15
+828.17%
12.08
-96.58%
353.49
+27.26%
277.77
Issuance Of Capital Stock
112.15
+828.17%
12.08
-96.58%
353.49
+27.26%
277.77
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

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