ZYME Chart
About

Zymeworks Inc., a clinical-stage biotechnology company, discovers, develops, and commercializes biotherapeutics for the treatment of cancer, and autoimmune and inflammatory diseases (AIID). Its therapeutic platforms and fully integrated drug development engine provides the flexibility and compatibility to precisely engineer and develop highly differentiated antibody-based therapeutic candidates. The company's platforms include Azymetric multispecific antibody platform; Drug Conjugate platform includes a suite of proprietary cytotoxins comprising topoisomerase and microtubulin inhibiting toxins, stable linkers, and conjugation technologies; EFECT platform, which consists of a set of modifications to the Fc region of antibodies that enable the selective modulation of recruited cytotoxic immune cells for various therapeutic applications; and ProTECT, a tumor-specific immune co-stimulation platform. Its lead product candidate consists of zanidatamab, a novel bispecific antibody that targets human epidermal growth factor receptor 2 HER2 that is in Phase 1, Phase 2, and Phase 3 clinical trials, including certain ongoing pivotal clinical trials; and zanidatamab zovodotin, a HER2 -targeted antibody-drug conjugate that is in Phase 2 clinical trial for the treatment of advanced or metastatic HER2-expressing tumors. In addition, the company develops a pipeline of preclinical product candidates. It has strategic partnerships and collaborations with BeiGene, Ltd.; Celgene Corporation; Celgene Alpine Investment Co. LLC; GlaxoSmithKline Intellectual Property Development Limited; Daiichi Sankyo Co., Ltd.; Iconic Therapeutics, Inc.; Merck Sharp & Dohme Research GmbH; and Atreca, Inc. Zymeworks Inc. was incorporated in 2003 and is based in Middletown, Delaware.

Fundamentals
Scroll to Statements
Sector Healthcare Industry Biotechnology Market Cap 1.86B
Enterprise Value 1.54B Income -63.43M Sales 134.48M
Book/sh 4.26 Cash/sh 3.37 Dividend Yield —
Payout 0.00% Employees 263 IPO —
P/E — Forward P/E 49.29 PEG —
P/S 13.79 P/B 5.72 P/C —
EV/EBITDA -25.18 EV/Sales 11.42 Quick Ratio 6.69
Current Ratio 6.94 Debt/Eq 5.91 LT Debt/Eq —
EPS (ttm) -0.85 EPS next Y 0.49 EPS Growth —
Revenue Growth 72.60% Earnings 2026-03-02 ROA -9.98%
ROE -18.46% ROIC — Gross Margin -6.21%
Oper. Margin -80.07% Profit Margin -47.16% Shs Outstand 74.84M
Shs Float 73.88M Short Float 7.40% Short Ratio 4.04
Short Interest — 52W High 28.49 52W Low 9.03
Beta 1.24 Avg Volume 801.32K Volume 198.82K
Target Price $36.46 Recom Strong_buy Prev Close $23.63
Price $24.36 Change 3.09%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$36.46
Mean price target
2. Current target
$24.36
Latest analyst target
3. DCF / Fair value
$-10.72
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$24.36
Low
$30.00
High
$52.00
Mean
$36.46

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2025-12-17 init Truist Securities — → Buy $40
2025-12-12 up Wells Fargo Equal-Weight → Overweight $33
2025-12-03 init Citizens — → Market Outperform $32
2025-11-21 reit B. Riley Securities Buy → Buy $40
2025-11-19 main Wells Fargo Equal-Weight → Equal-Weight $25
2025-11-19 main Stifel Buy → Buy $40
2025-11-18 main HC Wainwright & Co. Buy → Buy $32
2025-11-07 main Wells Fargo Equal-Weight → Equal-Weight $17
2025-10-16 main JP Morgan Overweight → Overweight $23
2025-10-14 up HC Wainwright & Co. Neutral → Buy $26
2025-10-10 init B. Riley Securities — → Buy $30
2025-08-11 main Citigroup Buy → Buy $22
2025-07-03 reit HC Wainwright & Co. Neutral → Neutral $13
2025-05-20 init TD Securities — → Buy —
2025-03-11 init LifeSci Capital — → Outperform $30
2025-03-10 main HC Wainwright & Co. Neutral → Neutral $13
2025-03-07 main Citigroup Buy → Buy $19
2024-12-19 main Wells Fargo Equal-Weight → Equal-Weight $14
2024-12-16 up JP Morgan Neutral → Overweight $18
2024-11-22 reit HC Wainwright & Co. Neutral → Neutral $12
Insider Transactions
Date Shares Value Url Text Insider Position Transaction Start Date Ownership
0 9560 216759.0 — Sale at price 22.67 per share. MOORE PAUL ANDREW Officer — 2026-01-12 00:00:00 D
1 17666 nan — — MOORE PAUL ANDREW Officer — 2026-01-12 00:00:00 D
2 6120 138762.0 — Sale at price 22.67 per share. HOLLYWOOD MARK Chief Operating Officer — 2026-01-12 00:00:00 D
3 17666 nan — — HOLLYWOOD MARK Chief Operating Officer — 2026-01-12 00:00:00 D
4 9310 211090.0 — Sale at price 22.67 per share. SMITH JEFFREY T L MD, FRCP Officer — 2026-01-12 00:00:00 D
5 17666 nan — — SMITH JEFFREY T L MD, FRCP Officer — 2026-01-12 00:00:00 D
6 30424 689819.0 — Sale at price 22.67 per share. GALBRAITH KENNETH HARRY Chief Executive Officer — 2026-01-12 00:00:00 D
7 64000 nan — — GALBRAITH KENNETH HARRY Chief Executive Officer — 2026-01-12 00:00:00 D
8 459 11099.0 — Stock Award(Grant) at price 24.18 per share. PATTERSON LEONE D. CPA Chief Financial Officer — 2026-01-06 00:00:00 D
9 20110 504699.0 — Sale at price 25.10 per share. MOORE PAUL ANDREW Officer — 2026-01-05 00:00:00 D
Financials
Line Item2024-12-312023-12-312022-12-312021-12-31
TaxEffectOfUnusualItems-3.47M-5.64K92.79K2.89K
TaxRateForCalcs0.210.000.080.00
NormalizedEBITDA-92.11M-119.52M141.34M-207.28M
TotalUnusualItems-16.51M-1.19M1.15M1.19M
TotalUnusualItemsExcludingGoodwill-16.51M-1.19M1.15M1.19M
NetIncomeFromContinuingOperationNetMinorityInterest-122.69M-118.67M124.34M-211.84M
ReconciledDepreciation11.19M17.30M12.00M9.58M
EBITDA-108.62M-120.70M142.49M-206.09M
EBIT-119.82M-138.01M130.49M-215.67M
NetInterestIncome19.94M19.70M3.60M1.97M
InterestIncome19.94M19.70M3.60M1.97M
NormalizedIncome-109.65M-117.49M123.28M-213.03M
NetIncomeFromContinuingAndDiscontinuedOperation-122.69M-118.67M124.34M-211.84M
TotalExpenses196.12M214.02M282.00M242.35M
TotalOperatingIncomeAsReported-137.11M-138.05M130.53M-215.63M
DilutedAverageShares75.88M68.86M65.25M52.13M
BasicAverageShares75.85M68.86M65.19M51.55M
DilutedEPS-1.62-1.721.90-4.61
BasicEPS-1.62-1.721.91-4.11
DilutedNIAvailtoComStockholders-122.56M-118.67M124.11M-240.38M
AverageDilutionEarnings140.00K0.00-231.00K-28.53M
NetIncomeCommonStockholders-122.69M-118.67M124.34M-211.84M
OtherunderPreferredStockDividend231.00K28.53M
NetIncome-122.69M-118.67M124.34M-211.84M
NetIncomeIncludingNoncontrollingInterests-122.69M-118.67M124.34M-211.84M
NetIncomeContinuousOperations-122.69M-118.67M124.34M-211.84M
TaxProvision6.08M-568.00K10.89M-516.00K
PretaxIncome-116.61M-119.24M135.23M-212.36M
OtherIncomeExpense-16.73M-894.00K1.11M1.31M
OtherNonOperatingIncomeExpenses-218.00K291.00K-42.00K118.00K
SpecialIncomeCharges-17.29M0.000.00
ImpairmentOfCapitalAssets17.29M0.000.00
GainOnSaleOfSecurity776.00K-1.19M1.15M1.19M
NetNonOperatingInterestIncomeExpense19.94M19.70M3.60M1.97M
InterestIncomeNonOperating19.94M19.70M3.60M1.97M
OperatingIncome-119.82M-138.01M130.49M-215.67M
OperatingExpense196.12M214.02M282.00M242.35M
ResearchAndDevelopment134.62M143.62M208.60M199.75M
SellingGeneralAndAdministration61.50M70.40M73.40M42.60M
GeneralAndAdministrativeExpense61.50M70.40M73.40M42.60M
OtherGandA35.40M48.10M49.60M24.70M
SalariesAndWages26.10M22.30M23.80M17.90M
TotalRevenue76.30M76.01M412.48M26.68M
OperatingRevenue76.30M76.01M412.48M26.68M
Line Item2024-12-312023-12-312022-12-312021-12-31
OrdinarySharesNumber68.96M70.12M63.06M46.63M
ShareIssued68.96M70.12M63.06M46.63M
TotalDebt18.51M26.72M28.11M32.33M
TangibleBookValue322.18M427.51M454.56M215.61M
InvestedCapital338.77M464.81M492.96M249.09M
WorkingCapital212.16M357.16M449.08M216.37M
NetTangibleAssets322.18M427.51M454.56M215.61M
CapitalLeaseObligations18.51M26.72M28.11M32.33M
CommonStockEquity338.77M464.81M492.96M249.09M
TotalCapitalization338.77M464.81M492.96M249.09M
TotalEquityGrossMinorityInterest338.77M464.81M492.96M249.09M
StockholdersEquity338.77M464.81M492.96M249.09M
GainsLossesNotAffectingRetainedEarnings-6.95M-6.60M-6.66M-6.66M
OtherEquityAdjustments-6.95M-6.60M-6.66M-6.66M
RetainedEarnings-830.34M-677.44M-558.76M-683.10M
AdditionalPaidInCapital152.25M142.27M151.61M197.71M
CapitalStock1.02B1.01B906.76M741.15M
CommonStock1.02B1.01B906.76M741.15M
PreferredStock0.000.000.000.00
TotalLiabilitiesNetMinorityInterest124.32M116.07M155.77M140.04M
TotalNonCurrentLiabilitiesNetMinorityInterest36.03M60.31M60.14M68.19M
OtherNonCurrentLiabilities895.00K1.61M2.98M2.65M
NonCurrentDeferredLiabilities19.37M36.24M32.38M34.51M
NonCurrentDeferredRevenue14.61M32.94M30.59M32.94M
NonCurrentDeferredTaxesLiabilities4.76M3.30M1.79M1.57M
LongTermDebtAndCapitalLeaseObligation15.77M22.46M24.79M31.02M
LongTermCapitalLeaseObligation15.77M22.46M24.79M31.02M
CurrentLiabilities88.29M55.76M95.62M71.85M
OtherCurrentLiabilities1.26M2.53M1.64M7.75M
CurrentDeferredLiabilities25.59M3.70M2.35M0.00
CurrentDeferredRevenue25.59M3.70M2.35M0.00
CurrentDebtAndCapitalLeaseObligation2.74M4.26M3.32M1.31M
CurrentCapitalLeaseObligation2.74M4.26M3.32M1.31M
PensionandOtherPostRetirementBenefitPlansCurrent6.22M6.15M14.37M3.35M
PayablesAndAccruedExpenses52.48M39.12M73.94M59.44M
CurrentAccruedExpenses47.20M31.10M47.16M52.03M
Payables5.28M8.02M26.79M7.42M
OtherPayable729.00K1.84M2.24M
TotalTaxPayable1.38M1.81M17.08M0.00
IncomeTaxPayable128.00K1.81M840.00K0.00
AccountsPayable3.90M6.21M7.86M5.17M
TotalAssets463.09M580.88M648.73M389.13M
TotalNonCurrentAssets162.64M167.95M104.02M100.91M
OtherNonCurrentAssets8.92M7.57M
NonCurrentPrepaidAssets7.24M15.73M12.49M
NonCurrentDeferredAssets4.38M3.62M1.35M4.28M
NonCurrentDeferredTaxesAssets4.38M3.62M1.34M3.07M
InvestmentsAndAdvances98.43M81.93M886.00K886.00K
GoodwillAndOtherIntangibleAssets16.59M37.30M38.40M33.48M
OtherIntangibleAssets4.58M25.28M26.38M21.47M
Goodwill12.02M12.02M12.02M12.02M
NetPPE34.32M37.54M47.65M49.77M
AccumulatedDepreciation-17.83M-20.66M-13.30M-14.06M
GrossPPE52.15M58.20M60.95M63.83M
Leases15.19M20.99M20.96M9.10M
ConstructionInProgress0.00122.00K76.00K13.26M
OtherProperties30.00M29.50M32.63M35.31M
MachineryFurnitureEquipment6.96M7.58M7.28M6.16M
Properties0.000.000.000.00
CurrentAssets300.45M412.93M544.71M288.22M
OtherCurrentAssets18.86M19.12M19.07M20.00M
PrepaidAssets20.00M
Receivables55.81M19.48M33.40M15.61M
AccountsReceivable55.81M19.48M33.40M15.61M
CashCashEquivalentsAndShortTermInvestments225.78M374.33M492.23M252.61M
OtherShortTermInvestments159.67M216.77M91.32M50.74M
CashAndCashEquivalents66.10M157.56M400.91M201.87M
Line Item2024-12-312023-12-312022-12-312021-12-31
FreeCashFlow-113.11M-122.38M130.98M-205.74M
RepurchaseOfCapitalStock-30.05M0.000.00
RepaymentOfDebt-14.00K-21.00K-14.00K-17.00K
IssuanceOfCapitalStock0.0076.09M107.53M0.00
CapitalExpenditure-3.07M-4.08M-13.12M-13.29M
IncomeTaxPaidSupplementalData3.18M165.00K10.00M
EndCashPosition66.10M157.56M400.91M201.87M
BeginningCashPosition157.56M400.91M201.87M242.04M
EffectOfExchangeRateChanges286.00K354.00K203.00K-325.00K
ChangesInCash-91.74M-243.71M198.84M-39.84M
FinancingCashFlow-20.45M81.85M108.58M8.01M
CashFlowFromContinuingFinancingActivities-20.45M81.85M108.58M8.01M
NetOtherFinancingCharges-174.00K-53.00K-596.00K-470.00K
ProceedsFromStockOptionExercised9.79M5.83M1.66M8.50M
NetCommonStockIssuance-30.05M76.09M107.53M0.00
CommonStockPayments-30.05M0.000.00
CommonStockIssuance0.0076.09M107.53M0.00
NetIssuancePaymentsOfDebt-14.00K-21.00K-14.00K-17.00K
NetLongTermDebtIssuance-14.00K-21.00K-14.00K-17.00K
LongTermDebtPayments-14.00K-21.00K-14.00K-17.00K
InvestingCashFlow38.76M-207.25M-53.85M144.60M
CashFlowFromContinuingInvestingActivities38.76M-207.25M-53.85M144.60M
NetInvestmentPurchaseAndSale41.82M-203.18M-40.72M157.88M
SaleOfInvestment325.56M350.07M72.28M192.96M
PurchaseOfInvestment-283.74M-553.25M-113.00M-35.08M
NetIntangiblesPurchaseAndSale-1.07M-1.60M-4.97M-881.00K
PurchaseOfIntangibles-1.07M-1.60M-4.97M-881.00K
NetPPEPurchaseAndSale-1.99M-2.47M-8.15M-12.40M
PurchaseOfPPE-1.99M-2.47M-8.15M-12.40M
OperatingCashFlow-110.04M-118.30M144.11M-192.45M
CashFlowFromContinuingOperatingActivities-110.04M-118.30M144.11M-192.45M
ChangeInWorkingCapital-30.95M-25.55M4.01M393.00K
ChangeInOtherWorkingCapital3.56M3.70M
ChangeInOtherCurrentLiabilities-8.31M-3.66M-3.74M-26.00K
ChangeInPayablesAndAccruedExpense12.65M-43.80M27.32M16.48M
ChangeInPayable12.65M-43.80M27.32M16.48M
ChangeInAccountPayable14.34M-44.77M26.48M16.48M
ChangeInTaxPayable-1.68M970.00K840.00K0.00
ChangeInIncomeTaxPayable-1.68M970.00K840.00K0.00
ChangeInPrepaidAssets-2.49M4.29M-2.06M-15.79M
ChangeInReceivables-36.36M13.92M-17.51M-266.00K
ChangesInAccountReceivables-36.36M13.92M-17.51M-266.00K
OtherNonCashItems-1.88M630.00K-250.00K213.00K
StockBasedCompensation17.79M8.10M4.01M10.76M
UnrealizedGainLossOnInvestmentSecurities0.00667.00K0.00-167.00K
AssetImpairmentCharge17.29M0.000.000.00
DeferredTax691.00K-757.00K1.94M-953.00K
DeferredIncomeTax691.00K-757.00K1.94M-953.00K
DepreciationAmortizationDepletion11.19M17.30M12.00M9.58M
DepreciationAndAmortization11.19M17.30M12.00M9.58M
AmortizationCashFlow4.50M2.70M1.01M2.79M
AmortizationOfIntangibles4.50M2.70M1.01M2.79M
Depreciation6.70M14.60M10.99M6.79M
OperatingGainsLosses-1.48M-31.00K-1.96M-433.00K
NetForeignCurrencyExchangeGainLoss-1.48M-31.00K-1.96M-433.00K
NetIncomeFromContinuingOperations-122.69M-118.67M124.34M-211.84M
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

Public Trades for ZYME
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