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About

Monte Rosa Therapeutics, Inc., a clinical-stage biotechnology company, engages in the development of novel small molecule precision medicines that employ the body's natural mechanisms to selectively degrade therapeutically relevant proteins. The company develops orally bioavailable molecular glue degraders (MGDs), such as MRT-2359 for the treatment of MYC-driven tumors; MRT-6160 for the treatment of neurologic and systemic autoimmune and inflammatory diseases; and MRT-8102 for the treatment of inflammatory diseases driven by IL-1b and the NLRP3 inflammasome. In addition, it develops CDK2 to treat multiple cancers, including ovarian, endometrial, gastric and breast. Further, its pipeline includes programs in immunology and inflammation indications, oncology, cardiovascular, metabolic, and genetic diseases. The company also develops QuEEN, a discovery engine, to enable its target-centric MGD discovery and development approach and its rational design of MGD product candidates. It has a strategic collaboration and licensing agreement with F. Hoffmann-La Roche Ltd. to discover and develop MGDs against targets in cancer and neurological diseases. The company was incorporated in 2019 and is headquartered in Boston, Massachusetts.

Fundamentals
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Sector Healthcare Industry Biotechnology Market Cap 1.46B
Enterprise Value 899.82M Income 20.95M Sales 181.54M
Book/sh 3.98 Cash/sh 6.01 Dividend Yield —
Payout 0.00% Employees 147 IPO —
P/E 60.03 Forward P/E -13.91 PEG —
P/S 8.07 P/B 4.83 P/C —
EV/EBITDA 53.43 EV/Sales 4.96 Quick Ratio 6.45
Current Ratio 6.54 Debt/Eq 16.34 LT Debt/Eq —
EPS (ttm) 0.32 EPS next Y -1.38 EPS Growth —
Revenue Growth 38.50% Earnings 2026-03-19 ROA 1.37%
ROE 9.28% ROIC — Gross Margin 28.08%
Oper. Margin -258.26% Profit Margin 11.54% Shs Outstand 76.24M
Shs Float 46.36M Short Float 12.54% Short Ratio 3.05
Short Interest — 52W High 25.77 52W Low 3.50
Beta 1.62 Avg Volume 1.61M Volume 681.67K
Target Price $33.80 Recom Strong_buy Prev Close $19.51
Price $19.21 Change -1.54%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$33.80
Mean price target
2. Current target
$19.20
Latest analyst target
3. DCF / Fair value
$11.47
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$19.20
Low
$30.00
High
$37.00
Mean
$33.80

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-01-14 reit Piper Sandler Overweight → Overweight $37
2026-01-08 main Wells Fargo Overweight → Overweight $30
2026-01-08 main Guggenheim Buy → Buy $34
2025-12-16 up Wells Fargo Equal-Weight → Overweight $22
2025-11-07 main Wells Fargo Equal-Weight → Equal-Weight $13
2025-03-21 main Wells Fargo Equal-Weight → Equal-Weight $10
2025-03-21 main Wedbush Outperform → Outperform $17
2025-03-12 init LifeSci Capital — → Outperform $19
2024-12-19 down Wells Fargo Overweight → Equal-Weight $11
2024-09-12 reit Wedbush Outperform → Outperform $11
2024-08-12 main Wells Fargo Overweight → Overweight $17
2024-06-28 reit Piper Sandler Overweight → Overweight $16
2024-05-22 reit Wedbush Outperform → Outperform $11
2024-02-15 init Wedbush — → Outperform $11
2023-10-19 main JP Morgan Overweight → Overweight $11
2023-08-11 reit Credit Suisse Neutral → Neutral $11
2023-05-12 reit Credit Suisse Neutral → Neutral $11
2023-03-17 main Credit Suisse — → Neutral $11
2023-01-03 up Wells Fargo Equal-Weight → Overweight $19
2022-10-13 init UBS — → Buy $22
Insider Transactions
Date Shares Value Url Text Insider Position Transaction Start Date Ownership
0 5466 128373 — Sale at price 23.24 - 24.57 per share. WARMUTH MARKUS M.D. Chief Executive Officer — 2026-01-07 00:00:00 D
1 3155 47861 — Sale at price 15.17 per share. TOWNSON SHARON Officer — 2026-01-05 00:00:00 D
2 10135 153748 — Sale at price 15.17 per share. WARMUTH MARKUS M.D. Chief Executive Officer — 2026-01-05 00:00:00 D
3 3155 47861 — Sale at price 15.17 per share. JANKU FILIP Officer — 2026-01-05 00:00:00 D
4 3155 47861 — Sale at price 15.17 per share. NICKSON PHILIP Officer — 2026-01-05 00:00:00 D
5 1039 15762 — Sale at price 15.17 per share. DUNN EDMUND Officer — 2026-01-05 00:00:00 D
6 2629 39882 — Sale at price 15.17 per share. CHAMPOUX JENNIFER Chief Operating Officer — 2026-01-05 00:00:00 D
7 35000 — — Stock Award(Grant) at price 0.00 per share. TOWNSON SHARON Officer — 2026-01-02 00:00:00 D
8 90000 — — Stock Award(Grant) at price 0.00 per share. WARMUTH MARKUS M.D. Chief Executive Officer — 2026-01-02 00:00:00 D
9 31000 — — Stock Award(Grant) at price 0.00 per share. JANKU FILIP Officer — 2026-01-02 00:00:00 D
Financials
Line Item2024-12-312023-12-312022-12-312021-12-31
TaxEffectOfUnusualItems87.36K-217.77K0.000.00
TaxRateForCalcs0.210.210.000.00
NormalizedEBITDA-73.41M-136.05M-108.76M-70.59M
TotalUnusualItems416.00K-1.04M119.00K-162.00K
TotalUnusualItemsExcludingGoodwill416.00K-1.04M119.00K-162.00K
NetIncomeFromContinuingOperationNetMinorityInterest-72.70M-135.35M-108.50M-73.96M
ReconciledDepreciation8.12M6.22M3.75M2.13M
EBITDA-72.99M-137.09M-108.64M-70.75M
EBIT-81.11M-143.31M-112.38M-72.88M
NetInterestIncome10.57M9.33M3.76M46.00K
InterestIncome10.57M9.33M3.76M46.00K
NormalizedIncome-73.03M-134.53M-108.62M-73.80M
NetIncomeFromContinuingAndDiscontinuedOperation-72.70M-135.35M-108.50M-73.96M
TotalExpenses156.73M143.31M112.38M72.88M
TotalOperatingIncomeAsReported-81.11M-143.31M-112.38M-72.88M
DilutedAverageShares61.51M51.40M47.23M25.00M
BasicAverageShares61.51M51.40M47.23M25.00M
DilutedEPS-1.18-2.63-2.30-2.96
BasicEPS-1.18-2.63-2.30-2.96
DilutedNIAvailtoComStockholders-72.70M-135.35M-108.50M-73.96M
NetIncomeCommonStockholders-72.70M-135.35M-108.50M-73.96M
NetIncome-72.70M-135.35M-108.50M-73.96M
NetIncomeIncludingNoncontrollingInterests-72.70M-135.35M-108.50M-73.96M
NetIncomeContinuousOperations-72.70M-135.35M-108.50M-73.96M
TaxProvision2.57M338.00K0.00
PretaxIncome-70.13M-135.01M-108.50M-73.96M
OtherIncomeExpense416.00K-1.04M119.00K-1.12M
OtherNonOperatingIncomeExpenses-960.00K
SpecialIncomeCharges0.0024.00K109.00K0.00
GainOnSaleOfPPE0.0024.00K109.00K0.00
GainOnSaleOfSecurity416.00K-1.06M10.00K-162.00K
NetNonOperatingInterestIncomeExpense10.57M9.33M3.76M46.00K
InterestIncomeNonOperating10.57M9.33M3.76M46.00K
OperatingIncome-81.11M-143.31M-112.38M-72.88M
OperatingExpense156.73M143.31M112.38M72.88M
ResearchAndDevelopment121.56M111.27M85.06M57.16M
SellingGeneralAndAdministration35.17M32.04M27.32M15.73M
GeneralAndAdministrativeExpense35.17M32.04M27.32M15.73M
OtherGandA13.02M12.39M11.94M6.24M
SalariesAndWages22.15M19.65M15.39M9.48M
TotalRevenue75.62M0.000.000.00
OperatingRevenue75.62M0.000.000.00
Line Item2022-12-31
TreasurySharesNumber122.27K
OrdinarySharesNumber61.51M50.14M49.32M46.54M
ShareIssued61.51M50.14M49.45M46.54M
TotalDebt42.72M46.04M47.00M0.00
TangibleBookValue222.94M179.25M271.41M347.51M
InvestedCapital222.94M179.25M271.41M347.51M
WorkingCapital220.49M189.62M250.32M332.03M
NetTangibleAssets222.94M179.25M271.41M347.51M
CapitalLeaseObligations42.72M46.04M47.00M0.00
CommonStockEquity222.94M179.25M271.41M347.51M
TotalCapitalization222.94M179.25M271.41M347.51M
TotalEquityGrossMinorityInterest222.94M179.25M271.41M347.51M
StockholdersEquity222.94M179.25M271.41M347.51M
GainsLossesNotAffectingRetainedEarnings-3.36M-2.72M-1.75M-2.02M
OtherEquityAdjustments-3.36M-2.72M-1.75M-2.02M
RetainedEarnings-438.59M-365.89M-230.54M-122.03M
AdditionalPaidInCapital664.87M547.86M503.70M471.57M
CapitalStock6.00K5.00K5.00K5.00K
CommonStock6.00K5.00K5.00K5.00K
PreferredStock0.000.00
TotalLiabilitiesNetMinorityInterest215.80M124.50M70.98M18.81M
TotalNonCurrentLiabilitiesNetMinorityInterest58.85M77.91M45.41M2.18M
PreferredSecuritiesOutsideStockEquity0.000.000.000.00
EmployeeBenefits3.70M2.71M1.53M2.18M
NonCurrentPensionAndOtherPostretirementBenefitPlans3.70M2.71M1.53M2.18M
NonCurrentDeferredLiabilities16.15M32.32M0.00
NonCurrentDeferredRevenue16.15M32.32M0.00
LongTermDebtAndCapitalLeaseObligation39.00M42.88M43.87M0.00
LongTermCapitalLeaseObligation39.00M42.88M43.87M0.00
CurrentLiabilities156.95M46.59M25.57M16.64M
OtherCurrentLiabilities3.35M1.67M5.02M840.00K
CurrentDeferredLiabilities117.23M17.68M0.00
CurrentDeferredRevenue117.23M17.68M0.00
CurrentDebtAndCapitalLeaseObligation3.71M3.16M3.13M
CurrentCapitalLeaseObligation3.71M3.16M3.13M0.00
PensionandOtherPostRetirementBenefitPlansCurrent8.22M7.59M5.62M4.30M
PayablesAndAccruedExpenses24.43M16.49M11.80M11.49M
CurrentAccruedExpenses7.21M5.34M3.94M4.94M
Payables17.21M11.15M7.86M6.56M
AccountsPayable17.21M11.15M7.86M6.56M
TotalAssets438.73M303.75M342.39M366.33M
TotalNonCurrentAssets61.29M67.54M66.50M17.66M
OtherNonCurrentAssets4.98M4.93M4.60M5.34M
NetPPE56.31M62.61M61.91M12.32M
AccumulatedDepreciation-20.36M-12.24M-6.25M-2.70M
GrossPPE76.68M74.86M68.16M15.03M
Leases22.39M20.89M2.66M1.12M
ConstructionInProgress64.00K924.00K12.01M852.00K
OtherProperties51.87M50.89M52.60M12.31M
MachineryFurnitureEquipment2.35M2.15M887.00K742.00K
Properties0.000.000.000.00
CurrentAssets377.44M236.21M275.89M348.67M
OtherCurrentAssets5.12M3.29M4.44M2.60M
RestrictedCash0.00960.00K0.00
PrepaidAssets2.60M
Receivables173.00K505.00K7.66M0.00
OtherReceivables173.00K505.00K7.66M
CashCashEquivalentsAndShortTermInvestments372.15M232.41M262.83M346.07M
OtherShortTermInvestments147.90M104.31M207.91M0.00
CashAndCashEquivalents224.25M128.10M54.91M346.07M
Line Item2024-12-312023-12-312022-12-312021-12-31
FreeCashFlow38.01M-62.84M-105.38M-69.09M
RepurchaseOfCapitalStock-641.00K-116.00K
IssuanceOfCapitalStock944.00K0.0020.05M380.75M
CapitalExpenditure-3.99M-19.04M-12.91M-9.73M
EndCashPosition229.12M132.68M60.19M351.41M
BeginningCashPosition132.68M60.19M351.41M42.86M
ChangesInCash96.44M72.49M-291.22M308.55M
FinancingCashFlow98.89M27.49M20.47M377.56M
CashFlowFromContinuingFinancingActivities98.89M27.49M20.47M377.56M
NetOtherFinancingCharges47.00M-116.00K-364.00K-3.34M
ProceedsFromStockOptionExercised51.59M27.61M775.00K149.00K
NetPreferredStockIssuance0.00143.00M
PreferredStockIssuance0.00143.00M
NetCommonStockIssuance303.00K-116.00K20.05M237.75M
CommonStockPayments-641.00K-116.00K
CommonStockIssuance944.00K0.0020.05M237.75M
InvestingCashFlow-44.45M88.80M-219.22M-9.65M
CashFlowFromContinuingInvestingActivities-44.45M88.80M-219.22M-9.65M
NetInvestmentPurchaseAndSale-40.46M107.78M-206.42M0.00
SaleOfInvestment189.90M210.93M178.00M0.00
PurchaseOfInvestment-230.36M-103.15M-384.42M0.00
NetPPEPurchaseAndSale-3.99M-18.98M-12.80M-9.65M
SaleOfPPE0.0062.00K109.00K79.00K
PurchaseOfPPE-3.99M-19.04M-12.91M-9.73M
OperatingCashFlow42.00M-43.80M-92.47M-59.36M
CashFlowFromContinuingOperatingActivities42.00M-43.80M-92.47M-59.36M
ChangeInWorkingCapital91.40M72.47M-2.13M6.29M
ChangeInOtherWorkingCapital82.22M60.18M-107.00K1.11M
ChangeInPayablesAndAccruedExpense10.44M9.31M287.00K5.88M
ChangeInAccruedExpense4.18M3.56M1.03M6.59M
ChangeInPayable6.25M5.76M-744.00K-706.00K
ChangeInAccountPayable6.25M5.76M-744.00K-706.00K
ChangeInPrepaidAssets-1.59M1.08M-2.13M-704.00K
ChangeInReceivables332.00K1.90M-187.00K0.00
OtherNonCashItems4.81M960.00K
StockBasedCompensation18.13M16.67M11.66M5.20M
AmortizationOfSecurities-2.95M-3.91M-1.95M0.00
DepreciationAmortizationDepletion8.12M6.22M3.75M2.13M
DepreciationAndAmortization8.12M6.22M3.75M2.13M
Depreciation8.12M6.22M3.75M2.13M
OperatingGainsLosses107.00K-109.00K17.00K
GainLossOnInvestmentSecurities131.00K
GainLossOnSaleOfPPE0.00-24.00K-109.00K17.00K
NetIncomeFromContinuingOperations-72.70M-135.35M-108.50M-73.96M
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

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