Symbols / NCNA $1.66 +1.84% NuCana plc

Healthcare • Biotechnology • United Kingdom • NCM
NCNA Chart
About

NuCana plc, a clinical-stage biopharmaceutical company, engages in the development of medicines to treat patients with cancer in the United States. It applies its ProTide technology to transform prescribed chemotherapy agents and nucleoside analogs into medicines. The company is developing medicines to overcome the limitations of nucleoside analogs and generate concentrations of anti-cancer metabolites in cancer cells. Its pipeline includes NUC-3373, a chemical entity derived from the nucleoside analog 5-fluorouracil that is in Phase 1b/2 study in patients with metastatic colorectal cancer; Phase 2 clinical trial for the second-line treatment of patients with advanced colorectal cancer; and Phase 1b/2 modular clinical trial for patients with advanced solid tumors and lung cancer. It also developing NUC-7738, a ProTide transformation of 3'-deoxyadenosine, which is in the Phase 2 part of a Phase 1/2 clinical trial for patients with advanced solid tumors. It has an assignment, license, and collaboration agreement with Cardiff ProTides Ltd to discover, drug design, and in vitro screen purine and pyrimidine-based nucleosides as potential drug candidates. The company was formerly known as NuCana BioMed Limited and changed its name to NuCana plc in August 2017. NuCana plc was incorporated in 1997 and is based in Edinburgh, the United Kingdom.

Fundamentals
Scroll to Statements
Sector Healthcare Industry Biotechnology Market Cap 6.91M
Enterprise Value 33.90B Income -29.35M Sales —
Book/sh 7.74 Cash/sh 0.00 Dividend Yield —
Payout 0.00% Employees 10 IPO —
P/E inf Forward P/E -0.18 PEG —
P/S — P/B 0.21 P/C —
EV/EBITDA -1645.10 EV/Sales — Quick Ratio 5.44
Current Ratio 5.60 Debt/Eq 2.78 LT Debt/Eq —
EPS (ttm) 0.00 EPS next Y -9.43 EPS Growth —
Revenue Growth — Earnings 2025-03-20 16:00 ROA -58.32%
ROE -193.87% ROIC — Gross Margin 0.00%
Oper. Margin 0.00% Profit Margin 0.00% Shs Outstand 4.16M
Shs Float 20.81B Short Float 3.85% Short Ratio 4.37
Short Interest — 52W High 250.00 52W Low 1.33
Beta 1.80 Avg Volume 59.27K Volume 12.75K
Target Price — Recom None Prev Close $1.63
Price $1.66 Change 1.84%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
—
Mean price target
2. Current target
$1.67
Latest analyst target
3. DCF / Fair value
$-16.54
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$1.67
Low
—
High
—
Mean
—

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2024-08-19 reit Oppenheimer Outperform → Outperform $150
2024-07-23 reit Oppenheimer Outperform → Outperform $150
2024-07-22 main Oppenheimer Outperform → Outperform $150
2024-04-01 reit Oppenheimer Outperform → Outperform $4
2023-11-21 reit Oppenheimer Outperform → Outperform $4
2023-09-06 reit Truist Securities Buy → Buy $6
2023-08-18 reit Oppenheimer Outperform → Outperform $4
2023-05-22 reit Oppenheimer Outperform → Outperform $4
2022-09-22 main Jefferies — → Buy $3
2022-03-03 down Cowen & Co. Outperform → Market Perform —
2021-11-24 main HC Wainwright & Co. — → Buy $9
2020-12-01 main HC Wainwright & Co. — → Buy $10
2020-11-24 main HC Wainwright & Co. — → Buy $15
2020-10-22 init Truist Securities — → Buy $22
2020-08-21 main HC Wainwright & Co. — → Buy $17
2020-07-24 init Oppenheimer — → Outperform $20
2020-03-11 main HC Wainwright & Co. — → Buy $16
2019-11-15 reit HC Wainwright & Co. — → Buy $17
2019-08-19 init HC Wainwright & Co. — → Buy $20
2018-10-19 init Piper Sandler — → Overweight $36
News
RSS: Latest NCNA news
Insider Transactions

No recent insider transactions.

Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
0.00
0.00
0.00
0.00
Operating Revenue
0.00
0.00
0.00
0.00
Operating Expense
20.83
-9.44%
23.00
-26.09%
31.12
-28.80%
43.72
Research And Development
12.74
-29.31%
18.02
-28.11%
25.06
-31.20%
36.43
Selling General And Administration
8.10
+62.31%
4.99
-17.73%
6.06
-16.84%
7.29
General And Administrative Expense
8.10
+62.31%
4.99
-17.73%
6.06
-16.84%
7.29
Other Gand A
8.10
+62.31%
4.99
-17.73%
6.06
-16.84%
7.29
Total Expenses
20.83
-9.44%
23.00
-26.09%
31.12
-28.80%
43.72
Operating Income
-20.83
+9.44%
-23.00
+26.09%
-31.12
+28.80%
-43.72
Total Operating Income As Reported
-20.11
+11.83%
-22.81
+30.43%
-32.78
+16.20%
-39.12
EBITDA
-20.56
+8.56%
-22.48
+26.41%
-30.55
+28.93%
-42.98
Normalized EBITDA
-8.63
+61.93%
-22.68
+21.50%
-28.89
+39.28%
-47.58
Reconciled Depreciation
0.27
-47.51%
0.52
-9.22%
0.57
-21.45%
0.73
EBIT
-20.83
+9.44%
-23.00
+26.09%
-31.12
+28.80%
-43.72
Total Unusual Items
-11.93
-6184.18%
0.20
+111.81%
-1.66
-136.10%
4.59
Total Unusual Items Excluding Goodwill
-11.93
-6184.18%
0.20
+111.81%
-1.66
-136.10%
4.59
Special Income Charges
0.84
+2648.48%
-0.03
+93.44%
-0.50
-72.26%
-0.29
Other Special Charges
-0.84
—
—
—
Impairment Of Capital Assets
0.00
-100.00%
0.03
-93.44%
0.50
+72.26%
0.29
Net Income
-29.35
-54.51%
-19.00
+31.25%
-27.63
+13.71%
-32.02
Pretax Income
-30.52
-35.94%
-22.45
+29.91%
-32.03
+16.70%
-38.45
Net Non Operating Interest Income Expense
0.39
+7.82%
0.36
-52.52%
0.75
+12.71%
0.67
Net Interest Income
0.39
+7.82%
0.36
-52.52%
0.75
+12.71%
0.67
Interest Income Non Operating
0.39
+7.82%
0.36
-52.52%
0.75
+12.71%
0.67
Interest Income
0.39
+7.82%
0.36
-52.52%
0.75
+12.71%
0.67
Other Income Expense
-10.07
-5239.80%
0.20
+111.81%
-1.66
-136.10%
4.59
Other Non Operating Income Expenses
1.85
—
—
—
Gain On Sale Of Security
-12.77
-5674.67%
0.23
+119.81%
-1.16
-123.65%
4.89
Tax Provision
-1.17
+66.18%
-3.45
+21.46%
-4.40
+31.62%
-6.43
Tax Rate For Calcs
0.00
-75.13%
0.00
+12.04%
0.00
-17.91%
0.00
Tax Effect Of Unusual Items
-0.46
-1613.42%
0.03
+113.24%
-0.23
-129.64%
0.77
Net Income Including Noncontrolling Interests
-29.35
-54.51%
-19.00
+31.25%
-27.63
+13.71%
-32.02
Net Income From Continuing Operation Net Minority Interest
-29.35
-54.51%
-19.00
+31.25%
-27.63
+13.71%
-32.02
Net Income From Continuing And Discontinued Operation
-29.35
-54.51%
-19.00
+31.25%
-27.63
+13.71%
-32.02
Net Income Continuous Operations
-29.35
-54.51%
-19.00
+31.25%
-27.63
+13.71%
-32.02
Normalized Income
-17.88
+6.67%
-19.16
+26.86%
-26.20
+26.91%
-35.85
Net Income Common Stockholders
-29.35
-54.51%
-19.00
+31.25%
-27.63
+13.71%
-32.02
Diluted EPS
0.00
+100.00%
-1,300.00
+50.94%
-2,650.00
+13.11%
-3,050.00
Basic EPS
0.00
+100.00%
-1,300.00
+50.94%
-2,650.00
+13.11%
-3,050.00
Basic Average Shares
4.16
+27948.73%
0.01
+41.11%
0.01
+0.65%
0.01
Diluted Average Shares
4.16
+27948.73%
0.01
+41.11%
0.01
+0.65%
0.01
Diluted NI Availto Com Stockholders
-29.35
-54.51%
-19.00
+31.25%
-27.63
+13.71%
-32.02
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Assets
29.83
+101.94%
14.77
-46.88%
27.81
-52.26%
58.25
Current Assets
26.86
+119.01%
12.27
-50.98%
25.02
-54.44%
54.92
Cash Cash Equivalents And Short Term Investments
24.25
+259.33%
6.75
-60.82%
17.23
-58.90%
41.91
Cash And Cash Equivalents
24.25
+259.33%
6.75
-60.82%
17.23
-58.90%
41.91
Cash Financial
24.25
+259.33%
6.75
-60.82%
17.23
-58.90%
41.91
Receivables
1.86
-59.82%
4.64
-20.36%
5.83
-17.00%
7.02
Other Receivables
0.04
+70.83%
0.02
-38.46%
0.04
-22.00%
0.05
Taxes Receivable
1.82
-60.50%
4.62
-20.24%
5.79
-16.96%
6.97
Prepaid Assets
0.75
-14.94%
0.88
-55.46%
1.97
-40.44%
3.31
Other Current Assets
—
—
—
2.68
Total Non Current Assets
2.97
+18.49%
2.51
-10.14%
2.79
-16.26%
3.33
Net PPE
0.66
+234.01%
0.20
-62.19%
0.52
-39.84%
0.87
Gross PPE
1.67
+47.70%
1.13
-50.63%
2.29
-0.17%
2.30
Accumulated Depreciation
-1.01
-8.45%
-0.94
+47.23%
-1.77
-23.83%
-1.43
Machinery Furniture Equipment
0.58
+3.58%
0.56
-41.57%
0.95
+1.49%
0.94
Other Properties
1.09
+90.59%
0.57
-57.10%
1.34
-1.33%
1.36
Goodwill And Other Intangible Assets
2.20
-0.05%
2.20
+3.34%
2.13
-10.02%
2.37
Other Intangible Assets
2.20
-0.05%
2.20
+3.34%
2.13
-10.02%
2.37
Non Current Deferred Assets
0.12
+3.54%
0.11
-20.98%
0.14
+38.83%
0.10
Non Current Deferred Taxes Assets
0.12
+3.54%
0.11
-20.98%
0.14
+38.83%
0.10
Other Non Current Assets
—
—
—
—
Total Liabilities Net Minority Interest
5.51
-37.56%
8.82
-31.75%
12.92
-34.57%
19.75
Current Liabilities
4.79
-44.69%
8.67
-31.63%
12.68
-34.36%
19.31
Payables And Accrued Expenses
4.77
-44.20%
8.55
-31.41%
12.47
-16.68%
14.97
Payables
0.62
-78.13%
2.84
-19.58%
3.53
-28.90%
4.96
Accounts Payable
0.52
-80.70%
2.71
-19.85%
3.38
-29.73%
4.80
Current Accrued Expenses
4.15
-27.34%
5.71
-36.09%
8.94
-10.62%
10.00
Total Tax Payable
0.10
-26.12%
0.13
-13.55%
0.15
-4.32%
0.16
Current Debt And Capital Lease Obligation
0.02
-72.60%
0.07
-64.56%
0.21
-15.23%
0.24
Current Capital Lease Obligation
0.02
-72.60%
0.07
-64.56%
0.21
-15.23%
0.24
Total Non Current Liabilities Net Minority Interest
0.71
+363.64%
0.15
-37.90%
0.25
-43.89%
0.44
Long Term Debt And Capital Lease Obligation
0.66
+460.68%
0.12
-38.42%
0.19
-52.02%
0.40
Long Term Capital Lease Obligation
0.66
+460.68%
0.12
-38.42%
0.19
-52.02%
0.40
Long Term Provisions
0.06
+56.76%
0.04
-36.21%
0.06
+26.09%
0.05
Stockholders Equity
24.33
+308.58%
5.95
-60.01%
14.89
-61.33%
38.50
Common Stock Equity
24.33
+308.58%
5.95
-60.01%
14.89
-61.33%
38.50
Capital Stock
14.34
+152.42%
5.68
+168.73%
2.11
+0.91%
2.10
Common Stock
14.34
+152.42%
5.68
+168.73%
2.11
+0.91%
2.10
Share Issued
20,810.35
+14551.34%
142.04
+168.70%
52.86
+0.93%
52.37
Ordinary Shares Number
20,809.85
+14602.75%
141.54
+170.31%
52.36
+0.94%
51.87
Treasury Shares Number
0.50
+0.00%
0.50
+0.00%
0.50
+0.00%
0.50
Additional Paid In Capital
175.25
+19.91%
146.15
+3.43%
141.31
+0.14%
141.11
Retained Earnings
-252.33
-12.50%
-224.29
-7.99%
-207.71
-15.03%
-180.57
Gains Losses Not Affecting Retained Earnings
87.08
+11.04%
78.42
-0.95%
79.17
+4.35%
75.87
Other Equity Adjustments
87.08
+11.04%
78.42
-0.95%
79.17
+4.35%
75.87
Total Equity Gross Minority Interest
24.33
+308.58%
5.95
-60.01%
14.89
-61.33%
38.50
Total Capitalization
24.33
+308.58%
5.95
-60.01%
14.89
-61.33%
38.50
Working Capital
22.07
+513.17%
3.60
-70.84%
12.34
-65.34%
35.61
Invested Capital
24.33
+308.58%
5.95
-60.01%
14.89
-61.33%
38.50
Total Debt
0.68
+255.79%
0.19
-52.02%
0.40
-38.03%
0.64
Capital Lease Obligations
0.68
+255.79%
0.19
-52.02%
0.40
-38.03%
0.64
Net Tangible Assets
22.13
+489.32%
3.75
-70.57%
12.76
-64.69%
36.14
Tangible Book Value
22.13
+489.32%
3.75
-70.57%
12.76
-64.69%
36.14
Current Provisions
—
0.04
—
4.10
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
-7.47
+60.94%
-19.12
+27.69%
-26.44
-14.17%
-23.16
Cash Flow From Continuing Operating Activities
-7.47
+60.94%
-19.12
+27.69%
-26.44
-14.17%
-23.16
Net Income From Continuing Operations
-29.35
-54.51%
-19.00
+31.25%
-27.63
+13.71%
-32.02
Depreciation Amortization Depletion
0.27
-47.51%
0.52
-9.22%
0.57
-21.45%
0.73
Depreciation
0.08
-76.56%
0.34
-8.17%
0.37
—
Amortization Cash Flow
0.20
+5.41%
0.18
-11.06%
0.21
-71.58%
0.73
Depreciation And Amortization
0.27
-47.51%
0.52
-9.22%
0.57
-21.45%
0.73
Amortization Of Intangibles
0.20
+5.41%
0.18
-11.06%
0.21
-71.58%
0.73
Other Non Cash Items
12.28
+3701.76%
-0.34
+52.97%
-0.72
-11.88%
-0.65
Stock Based Compensation
10.03
+509.23%
1.65
-57.32%
3.86
-21.12%
4.89
Provisionand Write Offof Assets
-0.04
-500.00%
0.01
+100.24%
-4.11
-200.22%
4.10
Asset Impairment Charge
0.00
-100.00%
0.03
-93.44%
0.50
+72.26%
0.29
Deferred Tax
-1.17
+66.18%
-3.45
+21.46%
-4.40
+31.62%
-6.43
Deferred Income Tax
-1.17
+66.18%
-3.45
+21.46%
-4.40
+31.62%
-6.43
Operating Gains Losses
0.19
+152.57%
-0.37
-131.38%
1.18
+123.45%
-5.01
Net Foreign Currency Exchange Gain Loss
0.19
+152.57%
-0.37
-131.38%
1.18
+123.45%
-5.01
Change In Working Capital
-3.67
-68.21%
-2.18
-70.41%
-1.28
-134.41%
3.72
Change In Prepaid Assets
0.11
-93.72%
1.74
+40.76%
1.23
+301.95%
0.31
Change In Payables And Accrued Expense
-3.78
+3.55%
-3.92
-55.86%
-2.52
-173.62%
3.42
Change In Payable
-3.78
+3.55%
-3.92
-55.86%
-2.52
-173.62%
3.42
Change In Account Payable
-2.18
-225.82%
-0.67
+53.08%
-1.43
-148.02%
2.97
Investing Cash Flow
0.16
+101.27%
0.08
-97.26%
2.89
+2306.67%
0.12
Cash Flow From Continuing Investing Activities
0.16
+101.27%
0.08
-97.26%
2.89
+2306.67%
0.12
Net PPE Purchase And Sale
0.00
+100.00%
-0.00
+0.00%
-0.00
+66.67%
-0.01
Purchase Of PPE
0.00
+100.00%
-0.00
+0.00%
-0.00
+66.67%
-0.01
Capital Expenditure
-0.19
+34.13%
-0.29
+38.70%
-0.48
+7.72%
-0.52
Net Intangibles Purchase And Sale
-0.19
+33.22%
-0.29
+39.03%
-0.47
+6.32%
-0.51
Purchase Of Intangibles
-0.19
+33.22%
-0.29
+39.03%
-0.47
+6.32%
-0.51
Net Other Investing Changes
—
—
2.60
—
Financing Cash Flow
25.01
+205.55%
8.18
+15541.51%
-0.05
+67.08%
-0.16
Cash Flow From Continuing Financing Activities
25.01
+205.55%
8.18
+15541.51%
-0.05
+67.08%
-0.16
Net Issuance Payments Of Debt
-0.05
+75.78%
-0.22
+17.41%
-0.27
-18.94%
-0.23
Repayment Of Debt
-0.05
+75.78%
-0.22
+17.41%
-0.27
-18.94%
-0.23
Long Term Debt Payments
-0.05
+75.78%
-0.22
+17.41%
-0.27
-18.94%
-0.23
Net Long Term Debt Issuance
-0.05
+75.78%
-0.22
+17.41%
-0.27
-18.94%
-0.23
Net Common Stock Issuance
20.18
+131.24%
8.73
+3405.62%
0.25
0.00
Proceeds From Stock Option Exercised
6.22
+88771.43%
0.01
+75.00%
0.00
-93.94%
0.07
Net Other Financing Charges
-1.35
-309.12%
-0.33
-813.89%
-0.04
—
Changes In Cash
17.70
+263.04%
-10.86
+54.01%
-23.60
-1.75%
-23.20
Effect Of Exchange Rate Changes
-0.20
-151.72%
0.38
+135.00%
-1.08
-122.34%
4.85
Beginning Cash Position
6.75
-60.82%
17.23
-58.90%
41.91
-30.45%
60.26
End Cash Position
24.25
+259.33%
6.75
-60.82%
17.23
-58.90%
41.91
Free Cash Flow
-7.66
+60.54%
-19.41
+27.89%
-26.92
-13.69%
-23.68
Change In Income Tax Payable
-1.60
+50.83%
-3.25
-198.99%
-1.09
-345.93%
0.44
Change In Tax Payable
-1.60
+50.83%
-3.25
-198.99%
-1.09
-345.93%
0.44
Common Stock Issuance
20.18
+131.24%
8.73
+3405.62%
0.25
0.00
Interest Received CFI
0.35
-5.38%
0.37
-51.69%
0.77
+20.69%
0.64
Issuance Of Capital Stock
20.18
+131.24%
8.73
+3405.62%
0.25
0.00
Taxes Refund Paid
3.99
-0.67%
4.01
-28.24%
5.59
-22.51%
7.22
SEC Filings

No SEC filings found for this symbol (may be non-US or ticker not in SEC index).

Trades
Date User Broker Pattern Type Position Size Entry Price Trade P&L Status
Posts
Published Title Author Category