OPK Chart
About

OPKO Health, Inc. operates as a healthcare company, in the United States, Ireland, Chile, Spain, Israel, Mexico, and internationally. The company operates in two segments, Pharmaceutical and Diagnostics. The Pharmaceutical segment develops MDX2001, a tetra-specific antibody targeting several types of solid tumors in Phase 1 clinical trials; MDX2003, a tetra-specific antibody targeting two antigens for hematological tumors in Phase 1 clinical trials; and MDX2004, a trispecific immune modulator to rebuild and sustain the patient's own immune system. This segment also engages in the development of Epstein Barr Virus vaccine; Rayaldee, a patented extended-release product for oral administration containing 30 mcg of a prohormone; OPK-88006 oral and injectable product to regulate blood glucose and reduce body weight; NGENLA, recombinant human growth hormone product developed for the long-term treatment of pediatric patients with growth hormone deficiency. The Diagnostics segment offers laboratory testing services, such as detection, diagnosis, evaluation, monitoring, and treatment of diseases, as well as esoteric testing, molecular diagnostics, anatomical pathology, genetics, women's health, and correctional healthcare under the BioReference brand; and 4Kscore test. OPKO Health, Inc. was founded in 2006 and is headquartered in Miami, Florida.

Fundamentals
Scroll to Statements
Sector Healthcare Industry Diagnostics & Research Market Cap 890.53M
Enterprise Value 935.66M Income -225.68M Sales 606.88M
Book/sh 1.67 Cash/sh 0.48 Dividend Yield
Payout 0.00% Employees 2275 IPO
P/E Forward P/E -3.52 PEG
P/S 1.47 P/B 0.69 P/C
EV/EBITDA -7.35 EV/Sales 1.54 Quick Ratio 3.21
Current Ratio 3.97 Debt/Eq 31.29 LT Debt/Eq
EPS (ttm) -0.29 EPS next Y -0.33 EPS Growth
Revenue Growth -19.20% Earnings 2026-04-30 ROA -6.62%
ROE -17.14% ROIC Gross Margin 13.50%
Oper. Margin -28.98% Profit Margin -37.19% Shs Outstand 759.07M
Shs Float 339.36M Short Float 7.20% Short Ratio 9.75
Short Interest 52W High 1.87 52W Low 1.11
Beta 1.52 Avg Volume 3.17M Volume 1.65M
Target Price $3.40 Recom Buy Prev Close $1.19
Price $1.16 Change -2.52%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$3.40
Mean price target
2. Current target
$1.16
Latest analyst target
3. DCF / Fair value
$-3.11
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$1.16
Low
$1.40
High
$8.50
Mean
$3.40

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-03-02 main Barrington Research Outperform → Outperform $2
2025-11-20 init JP Morgan — → Neutral
2025-10-31 down Jefferies Buy → Hold $2
2025-10-30 main Barrington Research Outperform → Outperform $2
2025-05-01 main Barrington Research Outperform → Outperform $2
2025-04-25 init JP Morgan — → Neutral
2025-04-07 reit HC Wainwright & Co. Buy → Buy $3
2025-03-19 reit HC Wainwright & Co. Buy → Buy $3
2025-03-12 reit HC Wainwright & Co. Buy → Buy $3
2025-03-12 main Barrington Research Outperform → Outperform $2
2025-03-03 reit HC Wainwright & Co. Buy → Buy $3
2025-02-28 main Barrington Research Outperform → Outperform $2
2025-01-08 main HC Wainwright & Co. Buy → Buy $3
2024-11-08 main Barrington Research Outperform → Outperform $2
2024-09-26 reit HC Wainwright & Co. Buy → Buy $3
2024-09-20 main Barrington Research Outperform → Outperform $2
2024-09-17 reit Piper Sandler Overweight → Overweight $3
2024-09-17 reit HC Wainwright & Co. Buy → Buy $3
2024-08-08 main Barrington Research Outperform → Outperform $2
2024-07-18 main Piper Sandler Overweight → Overweight $3
Insider Transactions
Date Shares Value Url Text Insider Position Transaction Start Date Ownership
0 580000 768807 Purchase at price 1.30 - 1.34 per share. FROST PHILLIP MD ET AL Chief Executive Officer 2025-11-21 00:00:00 I
1 580000 771328 Purchase at price 1.32 - 1.35 per share. FROST PHILLIP MD ET AL Beneficial Owner of more than 10% of a Class of Security 2025-11-20 00:00:00 I
2 580000 759115 Purchase at price 1.28 - 1.32 per share. FROST PHILLIP MD ET AL Chief Executive Officer 2025-11-19 00:00:00 I
3 533300 678906 Purchase at price 1.24 - 1.29 per share. FROST PHILLIP MD ET AL Beneficial Owner of more than 10% of a Class of Security 2025-11-18 00:00:00 I
4 46700 58842 Stock Award(Grant) at price 1.26 per share. FROST PHILLIP MD ET AL Beneficial Owner of more than 10% of a Class of Security 2025-11-18 00:00:00 I
5 150000 213435 Purchase at price 1.42 per share. FROST PHILLIP MD ET AL Beneficial Owner of more than 10% of a Class of Security 2025-10-31 00:00:00 I
6 440000 Stock Gift at price 0.00 per share. FROST PHILLIP MD ET AL Beneficial Owner of more than 10% of a Class of Security 2025-08-18 00:00:00 I
7 675000 891000 Purchase at price 1.32 per share. FROST PHILLIP MD ET AL Chief Executive Officer 2025-08-08 00:00:00 I
8 125000 184650 Purchase at price 1.48 per share. FROST PHILLIP MD ET AL Beneficial Owner of more than 10% of a Class of Security 2025-04-08 00:00:00 I
9 100000 164850 Purchase at price 1.65 per share. FROST PHILLIP MD ET AL Chief Executive Officer 2025-04-01 00:00:00 I
Financials
Line Item2025-12-312024-12-312023-12-312022-12-31
TaxEffectOfUnusualItems6.58M20.02M53.55K3.32M
TaxRateForCalcs0.070.210.210.16
NormalizedEBITDA-142.42M39.95M-65.77M-291.33M
TotalUnusualItems101.15M95.33M255.00K20.52M
TotalUnusualItemsExcludingGoodwill101.15M95.33M255.00K20.52M
NetIncomeFromContinuingOperationNetMinorityInterest-225.68M-53.22M-188.86M-328.40M
ReconciledDepreciation91.63M98.18M105.30M108.66M
ReconciledCostOfRevenue387.20M479.09M526.10M695.11M
EBITDA-41.27M135.28M-65.52M-270.81M
EBIT-132.90M37.10M-170.81M-379.46M
NetInterestIncome-93.65M-39.04M-9.52M-10.07M
InterestExpense108.46M47.47M13.51M12.06M
InterestIncome14.81M8.43M3.98M1.98M
NormalizedIncome-320.24M-128.54M-189.06M-345.60M
NetIncomeFromContinuingAndDiscontinuedOperation-225.68M-53.22M-188.86M-328.40M
TotalExpenses825.86M986.70M1.02B1.25B
TotalOperatingIncomeAsReported-117.41M-152.06M-157.02M-226.25M
DilutedAverageShares751.13M694.02M751.72M719.06M
BasicAverageShares751.13M694.02M751.72M719.06M
DilutedEPS-0.30-0.08-0.25-0.46
BasicEPS-0.30-0.08-0.25-0.46
DilutedNIAvailtoComStockholders-225.68M-53.22M-188.86M-328.40M
NetIncomeCommonStockholders-225.68M-53.22M-188.86M-328.40M
NetIncome-225.68M-53.22M-188.86M-328.40M
NetIncomeIncludingNoncontrollingInterests-225.68M-53.22M-188.86M-328.40M
NetIncomeContinuousOperations-225.68M-53.22M-188.86M-328.40M
EarningsFromEquityInterestNetOfTax-29.00K-18.00K-107.00K-383.00K
TaxProvision-15.71M42.84M4.44M-63.50M
PretaxIncome-241.36M-10.36M-184.32M-391.52M
OtherIncomeExpense71.27M302.24M-16.74M-135.32M
OtherNonOperatingIncomeExpenses-29.88M206.90M-16.99M-155.84M
SpecialIncomeCharges101.58M121.49M1.04M19.87M
GainOnSaleOfPPE101.58M121.49M0.0018.56M
WriteOff0.00
RestructuringAndMergernAcquisition0.000.00-1.04M-1.31M
GainOnSaleOfSecurity-429.00K-26.16M-781.00K649.00K
NetNonOperatingInterestIncomeExpense-93.65M-39.04M-9.52M-10.07M
InterestExpenseNonOperating108.46M47.47M13.51M12.06M
InterestIncomeNonOperating14.81M8.43M3.98M1.98M
OperatingIncome-218.99M-273.56M-158.06M-246.12M
OperatingExpense424.93M492.07M476.18M534.34M
DepreciationAmortizationDepletionIncomeStatement77.89M82.63M86.03M87.78M
DepreciationAndAmortizationInIncomeStatement77.89M82.63M86.03M87.78M
Amortization77.89M82.63M86.03M87.78M
AmortizationOfIntangiblesIncomeStatement77.89M82.63M86.03M87.78M
ResearchAndDevelopment124.03M105.21M89.59M73.89M
SellingGeneralAndAdministration223.00M304.22M300.56M372.67M
GrossProfit205.94M218.51M318.13M288.22M
CostOfRevenue400.94M494.63M545.37M715.98M
TotalRevenue606.88M713.14M863.50M1.00B
OperatingRevenue606.88M713.14M863.50M1.00B
Line Item2025-12-312024-12-312023-12-312022-12-31
TreasurySharesNumber30.85M29.80M8.66M8.66M
OrdinarySharesNumber759.07M671.55M773.28M772.65M
ShareIssued789.92M701.35M781.94M781.31M
NetDebt5.27M153.45M102.87M70.14M
TotalDebt396.78M504.44M326.56M305.55M
TangibleBookValue72.39M24.58M-144.32M-52.72M
InvestedCapital1.61B1.80B1.64B1.82B
WorkingCapital435.20M468.99M109.42M181.04M
NetTangibleAssets72.39M24.58M-144.32M-52.72M
CapitalLeaseObligations52.82M67.24M77.24M49.49M
CommonStockEquity1.27B1.37B1.39B1.56B
TotalCapitalization1.60B1.79B1.61B1.78B
TotalEquityGrossMinorityInterest1.27B1.37B1.39B1.56B
StockholdersEquity1.27B1.37B1.39B1.56B
GainsLossesNotAffectingRetainedEarnings-21.02M-56.13M-38.03M-43.32M
OtherEquityAdjustments-21.02M-56.13M-38.03M-43.32M
TreasuryStock3.18M1.79M1.79M1.79M
RetainedEarnings-2.29B-2.07B-2.01B-1.82B
AdditionalPaidInCapital3.57B3.48B3.43B3.42B
CapitalStock7.90M7.01M7.82M7.81M
CommonStock7.90M7.01M7.82M7.81M
TotalLiabilitiesNetMinorityInterest663.99M834.76M622.48M605.61M
TotalNonCurrentLiabilitiesNetMinorityInterest517.31M641.67M422.43M392.13M
OtherNonCurrentLiabilities11.60M11.50M12.20M11.05M
EmployeeBenefits5.54M14.27M0.00
NonCurrentPensionAndOtherPostretirementBenefitPlans5.54M14.27M0.00
NonCurrentDeferredLiabilities126.24M140.80M126.78M126.56M
NonCurrentDeferredRevenue6.00K7.00K138.00K208.00K
NonCurrentDeferredTaxesLiabilities126.24M140.80M126.77M126.43M
LongTermDebtAndCapitalLeaseObligation373.92M475.10M283.45M254.52M
LongTermCapitalLeaseObligation40.21M52.91M61.41M35.05M
LongTermDebt333.71M422.18M222.03M219.47M
CurrentLiabilities146.68M193.10M200.05M213.48M
OtherCurrentLiabilities28.16M
CurrentDeferredLiabilities0.000.00258.00K
CurrentDeferredRevenue0.000.00258.00K
CurrentDebtAndCapitalLeaseObligation22.86M29.35M43.12M51.03M
CurrentCapitalLeaseObligation12.61M14.33M15.82M14.44M
CurrentDebt10.25M15.02M27.29M36.59M
OtherCurrentBorrowings10.25M15.02M27.29M36.59M
PensionandOtherPostRetirementBenefitPlansCurrent33.78M34.17M28.95M33.77M
CurrentProvisions5.90M6.92M9.42M6.48M
PayablesAndAccruedExpenses84.14M122.66M118.56M122.21M
CurrentAccruedExpenses39.45M53.32M47.50M49.87M
InterestPayable5.44M8.31M
Payables44.70M69.35M71.06M72.34M
TotalTaxPayable3.60M22.27M1.38M5.35M
AccountsPayable41.10M47.07M69.68M66.99M
TotalAssets1.93B2.20B2.01B2.17B
TotalNonCurrentAssets1.35B1.54B1.70B1.77B
OtherNonCurrentAssets19.47M18.54M9.08M8.68M
FinancialAssets3.00K3.00K2.00K28.00K
InvestmentsAndAdvances14.16M54.58M16.08M28.05M
InvestmentinFinancialAssets13.41M53.79M5.50M6.03M
AvailableForSaleSecurities13.41M53.79M5.50M6.03M
LongTermEquityInvestment758.00K787.00K10.58M22.02M
GoodwillAndOtherIntangibleAssets1.20B1.34B1.53B1.61B
OtherIntangibleAssets711.28M811.61M935.28M1.02B
Goodwill484.29M529.25M598.26M595.85M
NetPPE120.86M124.14M143.52M121.60M
AccumulatedDepreciation-125.62M-138.70M-157.13M-142.41M
GrossPPE246.47M262.84M300.64M264.01M
Leases14.35M20.94M28.06M25.52M
ConstructionInProgress27.65M19.23M5.25M4.79M
OtherProperties46.93M54.00M68.09M38.73M
MachineryFurnitureEquipment139.44M153.36M177.93M174.34M
BuildingsAndImprovements15.57M13.06M18.89M18.31M
LandAndImprovements2.54M2.24M2.42M2.32M
Properties0.000.000.000.00
CurrentAssets581.88M662.09M309.48M394.52M
OtherCurrentAssets8.17M10.71M7.67M6.25M
AssetsHeldForSaleCurrent0.00314.99M
PrepaidAssets12.70M10.60M10.03M12.41M
Inventory65.82M56.80M65.70M74.06M
InventoriesAdjustmentsAllowances-3.52M-2.77M-6.46M-3.57M
FinishedGoods43.99M32.31M35.58M37.14M
WorkInProcess726.00K2.35M1.73M2.45M
RawMaterials24.62M24.91M34.84M38.05M
Receivables126.12M152.05M130.20M148.61M
OtherReceivables24.02M25.77M2.61M13.11M
TaxesReceivable11.84M8.27M4.21M8.19M
AccountsReceivable90.25M118.02M123.38M127.31M
AllowanceForDoubtfulAccountsReceivable-2.07M-1.27M-2.00M-4.16M
GrossAccountsReceivable92.33M119.28M125.38M131.47M
CashCashEquivalentsAndShortTermInvestments369.07M431.94M95.88M153.19M
CashAndCashEquivalents369.07M431.94M95.88M153.19M
Line Item2025-12-312024-12-312023-12-312022-12-31
FreeCashFlow-190.82M-208.50M-44.47M-119.77M
RepurchaseOfCapitalStock-47.04M-90.22M0.000.00
RepaymentOfDebt-103.79M-651.45M-682.71M-1.04B
IssuanceOfDebt33.03M939.43M671.68M1.06B
IssuanceOfCapitalStock0.00
CapitalExpenditure-12.28M-25.01M-16.27M-24.58M
InterestPaidSupplementalData37.94M20.88M8.13M7.42M
IncomeTaxPaidSupplementalData24.46M10.01M3.71M8.04M
EndCashPosition382.74M445.62M95.88M153.19M
BeginningCashPosition445.62M95.88M153.19M134.71M
EffectOfExchangeRateChanges3.43M-3.16M388.00K-339.00K
ChangesInCash-66.30M352.89M-57.70M18.82M
FinancingCashFlow-118.06M184.17M-11.30M22.97M
CashFlowFromContinuingFinancingActivities-118.06M184.17M-11.30M22.97M
NetOtherFinancingCharges-13.38M-188.00K
ProceedsFromStockOptionExercised-256.00K-208.00K-272.00K-774.00K
NetCommonStockIssuance-47.04M-90.22M0.000.00
CommonStockPayments-47.04M-90.22M0.000.00
CommonStockIssuance0.00
NetIssuancePaymentsOfDebt-70.76M287.98M-11.03M23.75M
NetShortTermDebtIssuance-11.24M
ShortTermDebtPayments-1.70B
ShortTermDebtIssuance1.68B
NetLongTermDebtIssuance-70.76M287.98M-11.03M23.75M
LongTermDebtPayments-103.79M-651.45M-682.71M-1.04B
LongTermDebtIssuance33.03M939.43M671.68M1.06B
InvestingCashFlow230.30M352.21M-18.20M91.04M
CashFlowFromContinuingInvestingActivities230.30M352.21M-18.20M91.04M
NetInvestmentPurchaseAndSale52.18M166.60M364.00K115.42M
SaleOfInvestment52.18M166.60M364.00K115.42M
NetBusinessPurchaseAndSale190.10M210.38M-5.00M-1.76M
SaleOfBusiness197.77M210.38M0.000.00
PurchaseOfBusiness-7.67M0.00-5.00M-1.76M
NetPPEPurchaseAndSale287.00K242.00K2.71M1.95M
SaleOfPPE287.00K242.00K2.71M1.95M
CapitalExpenditureReported-12.28M-25.01M-16.27M-24.58M
OperatingCashFlow-178.54M-183.49M-28.20M-95.19M
CashFlowFromContinuingOperatingActivities-178.54M-183.49M-28.20M-95.19M
ChangeInWorkingCapital-41.18M32.17M21.80M42.65M
ChangeInOtherWorkingCapital178.00K3.90M-1.04M2.37M
ChangeInOtherCurrentAssets-5.40M-3.74M6.88M-1.48M
ChangeInPayablesAndAccruedExpense-62.06M28.02M-2.65M-100.50M
ChangeInAccruedExpense-47.84M48.68M-5.48M-91.11M
ChangeInPayable-14.22M-20.66M2.83M-9.39M
ChangeInAccountPayable-14.22M-20.66M2.83M-9.39M
ChangeInInventory-4.12M4.22M15.20M13.66M
ChangeInReceivables30.21M-220.00K3.41M128.60M
ChangesInAccountReceivables30.21M-220.00K3.41M128.60M
OtherNonCashItems71.49M12.89M2.94M2.60M
StockBasedCompensation10.71M11.05M11.41M18.51M
UnrealizedGainLossOnInvestmentSecurities623.00K-114.43M17.65M153.84M
AssetImpairmentCharge1.01M0.000.000.00
DeferredTax-15.00M14.74M146.00K-74.41M
DeferredIncomeTax-15.00M14.74M146.00K-74.41M
DepreciationAmortizationDepletion91.63M98.18M105.30M108.66M
DepreciationAndAmortization91.63M98.18M105.30M108.66M
OperatingGainsLosses-72.14M-184.87M1.43M-18.63M
EarningsLossesFromEquityInvestments29.00K18.00K107.00K383.00K
NetForeignCurrencyExchangeGainLoss2.35M
GainLossOnSaleOfPPE-3.25M-63.40M1.32M-455.00K
GainLossOnSaleOfBusiness0.00-18.56M0.00
NetIncomeFromContinuingOperations-225.68M-53.22M-188.86M-328.40M
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

Public Trades for OPK
Date User Broker Pattern Type Position Size Entry Price Trade P&L Status