QURE Chart
About

uniQure N.V. develops treatments for patients suffering from rare and other devastating diseases in the United States. The company offers HEMGENIX that allows people living with hemophilia B to produce factor IX, which can lower the risk of bleeding. Its lead product candidate is AMT-130, a gene therapy candidate, which is in Phase I/II clinical study for the treatment of Huntington's disease. The company also develops AMT-260, which is in Phase I/IIa clinical trial for the treatment of mesial temporal lobe epilepsy; AMT-162, which is in Phase I/IIa clinical trial to treat superoxide dismutase enzyme-amyotrophic lateral sclerosis; and AMT-191, an investigational gene therapy candidate which is in phase I/IIa clinical trial for the treatment of fabry disease. It has a licensing agreement with Apic Bio to develop, manufacture, and commercialize intrathecally administered investigational gene therapy for ALS caused by mutations in SOD-1; and development and commercial supply agreement with CLS Bhering. uniQure N.V. was founded in 1998 and is headquartered in Amsterdam, the Netherlands.

Fundamentals
Scroll to Statements
Sector Healthcare Industry Biotechnology Market Cap 985.78M
Enterprise Value 910.77M Income -198.97M Sales 16.10M
Book/sh 3.19 Cash/sh 9.96 Dividend Yield
Payout 0.00% Employees 221 IPO
P/E Forward P/E -6.05 PEG
P/S 61.24 P/B 4.94 P/C
EV/EBITDA -5.54 EV/Sales 56.58 Quick Ratio 9.99
Current Ratio 10.43 Debt/Eq 269.78 LT Debt/Eq
EPS (ttm) -3.46 EPS next Y -2.60 EPS Growth
Revenue Growth 6.60% Earnings 2026-05-07 ROA -16.21%
ROE -207.10% ROIC Gross Margin 0.00%
Oper. Margin -9.01% Profit Margin 0.00% Shs Outstand 62.53M
Shs Float 49.09M Short Float 20.41% Short Ratio 4.65
Short Interest 52W High 71.50 52W Low 7.76
Beta 0.77 Avg Volume 3.39M Volume 978.17K
Target Price $38.26 Recom Buy Prev Close $15.94
Price $15.77 Change -1.10%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$38.23
Mean price target
2. Current target
$15.82
Latest analyst target
3. DCF / Fair value
$-30.73
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$15.82
Low
$8.89
High
$94.57
Mean
$38.23

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-03-11 up Mizuho Neutral → Outperform $35
2026-03-10 reit HC Wainwright & Co. Buy → Buy $70
2026-03-09 main Chardan Capital Buy → Buy $31
2026-03-09 up RBC Capital Sector Perform → Outperform $35
2026-03-09 up Wells Fargo Equal-Weight → Overweight $60
2026-03-03 main Goldman Sachs Neutral → Neutral $9
2026-03-03 down Wells Fargo Overweight → Equal-Weight $15
2026-03-03 main Chardan Capital Buy → Buy $16
2026-03-03 down Mizuho Outperform → Neutral $12
2026-03-02 up Cantor Fitzgerald Overweight → Neutral $9
2026-02-24 init Wolfe Research — → Peer Perform
2026-02-10 reit HC Wainwright & Co. Buy → Buy $70
2026-01-28 init Barclays — → Equal-Weight $31
2025-12-11 main Stifel Buy → Buy $40
2025-12-09 main Mizuho Outperform → Outperform $33
2025-12-04 main Chardan Capital Buy → Buy $53
2025-11-12 main Wells Fargo Overweight → Overweight $60
2025-11-11 main Chardan Capital Buy → Buy $53
2025-11-10 main Leerink Partners Outperform → Outperform $60
2025-11-04 main Goldman Sachs Neutral → Neutral $38
Insider Transactions
Date Shares Value Url Text Insider Position Transaction Start Date Ownership
0 12000 108720 Sale at price 9.06 per share. KLEMT CHRISTIAN Chief Financial Officer 2026-03-04 00:00:00 D
1 3412 30913 Sale at price 9.06 per share. POTTS JEANNETTE Officer 2026-03-04 00:00:00 D
2 808 7320 Sale at price 9.06 per share. ABI-SAAB WALID Officer 2026-03-04 00:00:00 D
3 14581 132104 Sale at price 9.06 per share. KAPUSTA MATTHEW C Chief Executive Officer 2026-03-04 00:00:00 D
4 70600 Stock Award(Grant) at price 0.00 per share. KAPUSTA MATTHEW C Chief Executive Officer 2026-03-04 00:00:00 D
5 39600 Stock Award(Grant) at price 0.00 per share. KLEMT CHRISTIAN Chief Financial Officer 2026-03-04 00:00:00 D
6 35400 Stock Award(Grant) at price 0.00 per share. POTTS JEANNETTE Officer 2026-03-04 00:00:00 D
7 41700 Stock Award(Grant) at price 0.00 per share. ABI-SAAB WALID Officer 2026-03-04 00:00:00 D
8 19800 Stock Award(Grant) at price 0.00 per share. O'KEEFE KYLIE Officer 2026-03-04 00:00:00 D
9 12532 124693 Sale at price 9.95 per share. KLEMT CHRISTIAN Chief Financial Officer 2026-03-02 00:00:00 D
Financials
Line Item2025-12-312024-12-312023-12-312022-12-31
TaxEffectOfUnusualItems8.29M-2.73M-733.24K298.39K
TaxRateForCalcs0.260.260.260.01
NormalizedEBITDA-148.72M-150.16M-250.26M-134.05M
TotalUnusualItems32.13M-10.58M-2.84M26.04M
TotalUnusualItemsExcludingGoodwill32.13M-10.58M-2.84M26.04M
NetIncomeFromContinuingOperationNetMinorityInterest-198.97M-239.56M-308.48M-126.79M
ReconciledDepreciation14.76M12.64M11.90M8.54M
ReconciledCostOfRevenue1.69M7.80M3.78M3.34M
EBITDA-116.59M-160.75M-253.10M-108.02M
EBIT-131.35M-173.39M-265.00M-116.56M
NetInterestIncome-45.03M-42.33M-22.00M-11.10M
InterestExpense61.99M63.74M41.56M11.70M
InterestIncome16.97M21.41M19.56M609.00K
NormalizedIncome-222.81M-231.71M-306.37M-152.53M
NetIncomeFromContinuingAndDiscontinuedOperation-198.97M-239.56M-308.48M-126.79M
TotalExpenses203.93M209.30M298.33M250.73M
RentExpenseSupplemental1.79M1.36M900.00K820.00K
TotalOperatingIncomeAsReported-185.35M-184.29M-282.87M-143.16M
DilutedAverageShares57.50M48.65M47.67M46.74M
BasicAverageShares57.50M48.65M47.67M46.74M
DilutedEPS-3.46-4.92-6.47-2.71
BasicEPS-3.46-4.92-6.47-2.71
DilutedNIAvailtoComStockholders-198.97M-239.56M-308.48M-126.79M
NetIncomeCommonStockholders-198.97M-239.56M-308.48M-126.79M
NetIncome-198.97M-239.56M-308.48M-126.79M
NetIncomeIncludingNoncontrollingInterests-198.97M-239.56M-308.48M-126.79M
NetIncomeContinuousOperations-198.97M-239.56M-308.48M-126.79M
TaxProvision5.63M2.43M1.92M-1.47M
PretaxIncome-193.34M-237.13M-306.56M-128.26M
OtherIncomeExpense39.51M-12.62M-2.08M27.12M
OtherNonOperatingIncomeExpenses7.38M-2.04M766.00K1.09M
SpecialIncomeCharges6.00M-73.00K-361.00K0.00
GainOnSaleOfPPE6.00M0.000.00
GainOnSaleOfBusiness0.001.15M0.000.00
RestructuringAndMergernAcquisition0.001.22M361.00K0.00
GainOnSaleOfSecurity26.13M-10.51M-2.48M26.04M
NetNonOperatingInterestIncomeExpense-45.03M-42.33M-22.00M-11.10M
InterestExpenseNonOperating61.99M63.74M41.56M11.70M
InterestIncomeNonOperating16.97M21.41M19.56M609.00K
OperatingIncome-187.83M-182.18M-282.49M-144.25M
OperatingExpense202.24M190.97M284.70M247.39M
OtherOperatingExpenses-5.68M-5.60M-5.29M-6.08M
DepreciationAmortizationDepletionIncomeStatement1.91M2.11M2.05M1.18M
DepreciationAndAmortizationInIncomeStatement1.91M2.11M2.05M1.18M
DepreciationIncomeStatement1.91M2.11M2.05M1.18M
ResearchAndDevelopment140.67M143.78M214.86M197.59M
SellingGeneralAndAdministration65.34M50.68M73.08M54.70M
GeneralAndAdministrativeExpense65.34M50.68M73.08M54.70M
OtherGandA28.50M16.05M30.39M17.33M
RentAndLandingFees1.79M1.36M900.00K820.00K
SalariesAndWages35.04M33.27M41.78M36.54M
GrossProfit14.41M8.79M2.21M103.14M
CostOfRevenue1.69M18.33M13.63M3.34M
TotalRevenue16.10M27.12M15.84M106.48M
OperatingRevenue16.10M27.12M15.84M106.48M
Line Item2025-12-312024-12-312023-12-312022-12-31
OrdinarySharesNumber62.53M48.99M47.83M46.97M
ShareIssued62.53M48.99M47.83M46.97M
TotalDebt63.39M66.06M138.41M142.89M
TangibleBookValue100.76M-100.21M120.81M391.65M
InvestedCapital248.60M44.57M309.42M578.80M
WorkingCapital593.07M350.24M578.18M400.86M
NetTangibleAssets100.76M-100.21M120.81M391.65M
CapitalLeaseObligations13.69M14.74M36.66M40.10M
CommonStockEquity198.90M-6.75M207.67M476.01M
TotalCapitalization248.60M44.57M309.42M578.80M
TotalEquityGrossMinorityInterest198.90M-6.75M207.67M476.01M
StockholdersEquity198.90M-6.75M207.67M476.01M
GainsLossesNotAffectingRetainedEarnings-58.22M-52.80M-53.55M-58.29M
OtherEquityAdjustments-58.22M-52.80M-53.55M-58.29M
RetainedEarnings-1.33B-1.13B-890.41M-581.93M
AdditionalPaidInCapital1.58B1.17B1.15B1.11B
CapitalStock3.69M2.94M2.88M2.84M
CommonStock3.69M2.94M2.88M2.84M
TotalLiabilitiesNetMinorityInterest626.01M563.29M624.02M228.96M
TotalNonCurrentLiabilitiesNetMinorityInterest563.09M523.24M550.34M153.04M
OtherNonCurrentLiabilities495.59M453.73M412.74M10.27M
NonCurrentDeferredLiabilities7.97M7.04M7.54M8.26M
NonCurrentDeferredTaxesLiabilities7.97M7.04M7.54M8.26M
LongTermDebtAndCapitalLeaseObligation59.53M62.46M130.06M134.51M
LongTermCapitalLeaseObligation9.83M11.14M28.32M31.72M
LongTermDebt49.70M51.32M101.75M102.79M
CurrentLiabilities62.92M40.05M73.67M75.92M
OtherCurrentLiabilities23.46M6.83M29.65M25.98M
CurrentDeferredLiabilities0.00
CurrentDeferredRevenue0.00
CurrentDebtAndCapitalLeaseObligation3.86M3.60M8.34M8.38M
CurrentCapitalLeaseObligation3.86M3.60M8.34M8.38M
PensionandOtherPostRetirementBenefitPlansCurrent9.94M12.29M16.26M17.20M
PayablesAndAccruedExpenses25.66M17.34M19.42M24.35M
CurrentAccruedExpenses20.49M10.11M12.83M13.37M
Payables5.17M7.23M6.59M10.98M
AccountsPayable5.17M7.23M6.59M10.98M
TotalAssets824.91M556.54M831.69M704.96M
TotalNonCurrentAssets168.92M166.25M179.84M228.19M
OtherNonCurrentAssets5.56M1.40M3.18M6.06M
NonCurrentDeferredAssets8.65M9.86M12.28M14.53M
NonCurrentDeferredTaxesAssets8.65M9.86M12.28M14.53M
InvestmentsAndAdvances30.24M27.46M2.18M39.98M
OtherInvestments30.24M27.46M2.18M
InvestmentinFinancialAssets0.0039.98M0.00
HeldToMaturitySecurities0.0039.98M0.00
GoodwillAndOtherIntangibleAssets98.14M93.46M86.86M84.36M
OtherIntangibleAssets72.79M71.04M60.48M58.78M
Goodwill25.36M22.41M26.38M25.58M
NetPPE26.32M34.07M75.34M83.26M
AccumulatedDepreciation-43.74M-31.66M-55.67M-44.13M
GrossPPE70.06M65.73M131.01M127.38M
Leases28.19M24.81M46.51M44.87M
ConstructionInProgress0.005.67M5.41M5.07M
OtherProperties37.52M37.01M72.45M72.12M
MachineryFurnitureEquipment4.36M3.91M6.38M4.99M
Properties0.000.000.000.00
CurrentAssets655.99M390.29M651.85M476.77M
OtherCurrentAssets7.08M7.61M2.65M2.81M
PrepaidAssets20.51M9.28M15.09M11.82M
Inventory0.0012.02M6.92M0.00
FinishedGoods0.00758.00K1.47M0.00
WorkInProcess0.004.11M1.87M0.00
RawMaterials0.007.16M3.58M0.00
Receivables5.86M5.88M4.19M102.38M
AccountsReceivable5.86M5.88M4.19M102.38M
CashCashEquivalentsAndShortTermInvestments622.54M367.52M617.89M352.84M
OtherShortTermInvestments542.30M208.59M376.53M124.83M
CashAndCashEquivalents80.24M158.93M241.36M228.01M
Line Item2025-12-312024-12-312023-12-312022-12-31
FreeCashFlow-178.40M-194.42M-153.08M-162.75M
RepaymentOfDebt0.00-53.05M0.000.00
IssuanceOfDebt0.000.0064.07M
IssuanceOfCapitalStock391.90M2.12M308.00K1.45M
CapitalExpenditure-439.00K-11.69M-7.15M-17.69M
InterestPaidSupplementalData25.07M20.57M16.88M9.25M
EndCashPosition81.80M160.33M244.54M231.17M
BeginningCashPosition160.33M244.54M231.17M559.35M
EffectOfExchangeRateChanges5.66M-4.97M2.27M-1.83M
ChangesInCash-84.18M-79.25M11.11M-326.35M
FinancingCashFlow415.40M-59.49M362.72M1.45M
CashFlowFromContinuingFinancingActivities415.40M-59.49M362.72M1.45M
NetOtherFinancingCharges-8.56M362.41M-1.33M
ProceedsFromStockOptionExercised23.50M0.000.002.80M
NetCommonStockIssuance391.90M2.12M308.00K1.45M
CommonStockIssuance391.90M2.12M308.00K1.45M
NetIssuancePaymentsOfDebt0.00-53.05M0.000.00
NetLongTermDebtIssuance0.00-53.05M0.000.00
LongTermDebtPayments0.00-53.05M0.000.00
LongTermDebtIssuance0.000.0064.07M
InvestingCashFlow-321.62M162.97M-205.69M-182.73M
CashFlowFromContinuingInvestingActivities-321.62M162.97M-205.69M-182.73M
NetInvestmentPurchaseAndSale-321.18M174.66M-198.53M-163.15M
SaleOfInvestment337.19M534.50M167.91M0.00
PurchaseOfInvestment-658.38M-359.84M-366.44M-163.15M
NetBusinessPurchaseAndSale0.000.00-1.90M-49.95M
PurchaseOfBusiness0.000.00-1.90M-49.95M
NetIntangiblesPurchaseAndSale0.000.00
PurchaseOfIntangibles0.000.00
NetPPEPurchaseAndSale-439.00K-11.69M-7.15M-17.69M
PurchaseOfPPE-439.00K-11.69M-7.15M-17.69M
OperatingCashFlow-177.96M-182.73M-145.93M-145.06M
CashFlowFromContinuingOperatingActivities-177.96M-182.73M-145.93M-145.06M
ChangeInWorkingCapital-6.79M-3.94M82.44M-43.38M
ChangeInPayablesAndAccruedExpense1.81M-4.12M-9.50M12.62M
ChangeInAccruedExpense4.47M-5.64M-5.33M3.38M
ChangeInPayable-2.67M1.52M-4.17M9.24M
ChangeInAccountPayable-2.67M1.52M-4.17M9.24M
ChangeInInventory0.002.42M-6.74M-6.92M
ChangeInReceivables-8.60M-2.24M98.68M-49.08M
ChangesInAccountReceivables-8.60M-2.24M-1.32M-4.08M
OtherNonCashItems39.66M18.93M44.32M5.92M
StockBasedCompensation17.68M22.26M35.09M34.20M
AmortizationOfSecurities-10.46M-10.90M-10.92M0.00
DeferredTax1.59M2.43M1.92M-1.47M
DeferredIncomeTax1.59M2.43M1.92M-1.47M
DepreciationAmortizationDepletion14.76M12.64M11.90M8.54M
DepreciationAndAmortization14.76M12.64M11.90M8.54M
Depreciation14.76M12.64M11.90M8.54M
OperatingGainsLosses-35.42M15.41M-2.21M-22.08M
GainLossOnInvestmentSecurities-12.40M6.84M
NetForeignCurrencyExchangeGainLoss-23.02M15.41M-2.21M-22.08M
NetIncomeFromContinuingOperations-198.97M-239.56M-308.48M-126.79M
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

Public Trades for QURE
Date User Broker Pattern Type Position Size Entry Price Trade P&L Status