Symbols / SEPN $24.85 -1.31% Septerna, Inc.

Healthcare • Biotechnology • United States • NGM
SEPN Chart
About

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

Fundamentals
Scroll to Statements
Sector Healthcare Industry Biotechnology Market Cap 1.12B
Enterprise Value 763.28M Income -48.88M Sales 45.95M
Book/sh 8.52 Cash/sh 8.71 Dividend Yield —
Payout 0.00% Employees 130 IPO —
P/E — Forward P/E -12.78 PEG —
P/S 24.29 P/B 2.92 P/C —
EV/EBITDA -9.64 EV/Sales 16.61 Quick Ratio 4.66
Current Ratio 4.73 Debt/Eq 6.19 LT Debt/Eq —
EPS (ttm) -1.10 EPS next Y -1.95 EPS Growth —
Revenue Growth 112.76% Earnings 2026-05-07 ROA -9.59%
ROE -12.19% ROIC — Gross Margin 100.00%
Oper. Margin -66.44% Profit Margin -106.37% Shs Outstand 44.91M
Shs Float 22.90M Short Float 7.95% Short Ratio 5.92
Short Interest — 52W High 32.63 52W Low 4.66
Beta — Avg Volume 300.72K Volume 82.00K
Target Price $44.43 Recom Strong_buy Prev Close $25.18
Price $24.85 Change -1.31%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$44.43
Mean price target
2. Current target
$24.78
Latest analyst target
3. DCF / Fair value
$7.54
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$24.78
Low
$35.00
High
$60.00
Mean
$44.43

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-03-24 main JP Morgan Overweight → Overweight $38
2026-03-11 main Truist Securities Buy → Buy $35
2026-03-03 main Wells Fargo Overweight → Overweight $48
2026-03-02 main HC Wainwright & Co. Buy → Buy $40
2026-01-20 main HC Wainwright & Co. Buy → Buy $35
2025-12-23 init Jones Trading — → Buy $43
2025-12-19 init Raymond James — → Strong Buy $38
2025-12-15 init Truist Securities — → Buy $34
2025-11-14 up Wells Fargo Equal-Weight → Overweight $28
2025-11-11 main HC Wainwright & Co. Buy → Buy $30
2025-09-05 reit Cantor Fitzgerald Overweight → Overweight $25
2025-08-21 reit HC Wainwright & Co. Buy → Buy $26
2025-06-23 init HC Wainwright & Co. — → Buy $26
2025-05-16 main Cantor Fitzgerald Overweight → Overweight $25
2025-05-16 main Wells Fargo Equal-Weight → Equal-Weight $18
2025-03-28 main Wells Fargo Equal-Weight → Equal-Weight $11
2025-02-18 down Wells Fargo Overweight → Equal-Weight $14
2025-02-11 reit Cantor Fitzgerald Overweight → Overweight $50
2024-11-19 init Cantor Fitzgerald — → Overweight $50
2024-11-19 init Wells Fargo — → Overweight $43
News
RSS: Latest SEPN news
Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2026-03-02 SHAIKHLY SAMIRA Officer — 70,453 $27.51 $1,979,838
2026-03-02 SHAIKHLY SAMIRA Officer — 70,453 $1.55 $129,456
2026-02-18 BHATT ELIZABETH President — 4,000 $28.46 $115,860
2026-02-18 BHATT ELIZABETH President — 4,000 $6.81 $27,240
2025-11-10 LONG DANIEL D Officer — 3,501 $18.06 $63,223
2025-08-18 KLEIN UWE Officer — 23,008 $2.76 $94,367
2025-04-03 FINER JEFFREY Chief Executive Officer — 55,000 $2.76 $151,800
2025-03-07 EZEKOWITZ ALAN Director — 13,319 $6.93 $92,270
2025-03-06 EZEKOWITZ ALAN Director — 86,681 $5.82 $515,934
2025-02-27 LABRUCHERIE GILBERT M JR Chief Financial Officer — 10,000 $5.59 $56,867
Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
45.95
+4174.51%
1.07
+611.92%
0.15
0.00
Operating Revenue
45.95
+4174.51%
1.07
+611.92%
0.15
0.00
Operating Expense
126.75
+54.76%
81.90
+79.20%
45.70
+63.41%
27.97
Research And Development
97.58
+49.35%
65.34
+81.60%
35.98
+63.21%
22.04
Selling General And Administration
29.16
+76.10%
16.56
+70.35%
9.72
+64.14%
5.92
General And Administrative Expense
29.16
+76.10%
16.56
+70.35%
9.72
+64.14%
5.92
Other Gand A
29.16
+76.10%
16.56
+70.35%
9.72
+64.14%
5.92
Total Expenses
126.75
+54.76%
81.90
+79.20%
45.70
+63.41%
27.97
Operating Income
-80.80
+0.03%
-80.82
-77.44%
-45.55
-62.87%
-27.97
Total Operating Income As Reported
-68.30
+15.50%
-80.82
-3995.08%
2.08
+107.42%
-27.97
EBITDA
-79.19
+0.29%
-79.42
-77.67%
-44.70
-63.21%
-27.39
Normalized EBITDA
-91.69
-15.45%
-79.42
+13.98%
-92.33
-237.08%
-27.39
Reconciled Depreciation
1.60
+14.49%
1.40
+65.21%
0.85
+46.97%
0.58
EBIT
-80.80
+0.03%
-80.82
-77.44%
-45.55
-62.87%
-27.97
Total Unusual Items
12.50
0.00
-100.00%
47.62
0.00
Total Unusual Items Excluding Goodwill
12.50
0.00
-100.00%
47.62
0.00
Special Income Charges
12.50
0.00
-100.00%
47.62
0.00
Net Income
-48.88
+31.92%
-71.80
-1817.66%
4.18
+115.10%
-27.68
Pretax Income
-48.87
+32.41%
-72.30
-1584.21%
4.87
+117.60%
-27.68
Net Non Operating Interest Income Expense
19.53
+126.65%
8.62
+209.30%
2.79
+857.39%
0.29
Net Interest Income
19.53
+126.65%
8.62
+209.30%
2.79
+857.39%
0.29
Interest Income Non Operating
19.53
+126.65%
8.62
+209.30%
2.79
+857.39%
0.29
Interest Income
19.53
+126.65%
8.62
+209.30%
2.79
+857.39%
0.29
Other Income Expense
12.40
+13877.78%
-0.09
-100.19%
47.63
—
Other Non Operating Income Expenses
-0.10
-11.11%
-0.09
-1000.00%
0.01
—
Tax Provision
0.01
+102.41%
-0.50
-172.07%
0.69
0.00
Tax Rate For Calcs
0.00
-100.00%
0.00
-95.07%
0.00
0.00
Tax Effect Of Unusual Items
0.00
0.00
-100.00%
6.76
0.00
Net Income Including Noncontrolling Interests
-48.88
+31.92%
-71.80
-1817.66%
4.18
+115.10%
-27.68
Net Income From Continuing Operation Net Minority Interest
-48.88
+31.92%
-71.80
-1817.66%
4.18
+115.10%
-27.68
Net Income From Continuing And Discontinued Operation
-48.88
+31.92%
-71.80
-1817.66%
4.18
+115.10%
-27.68
Net Income Continuous Operations
-48.88
+31.92%
-71.80
-1817.66%
4.18
+115.10%
-27.68
Normalized Income
-61.38
+14.51%
-71.80
-95.73%
-36.68
-32.54%
-27.68
Net Income Common Stockholders
-48.88
+31.92%
-71.80
-12762.79%
0.57
+102.05%
-27.68
Otherunder Preferred Stock Dividend
—
0.00
-100.00%
3.61
0.00
Diluted EPS
—
-7.26
-25063.04%
0.03
+102.05%
-1.42
Basic EPS
—
-7.26
-25063.04%
0.03
+102.05%
-1.42
Basic Average Shares
—
9.89
-49.27%
19.50
+0.00%
19.50
Diluted Average Shares
—
9.89
-49.27%
19.50
+0.00%
19.50
Diluted NI Availto Com Stockholders
-48.88
+31.92%
-71.80
-11514.63%
0.63
+102.27%
-27.68
Average Dilution Earnings
—
—
0.06
—
Gain On Sale Of PPE
12.50
0.00
-100.00%
47.62
0.00
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Assets
596.19
+30.58%
456.55
+248.87%
130.87
+262.32%
36.12
Current Assets
410.96
+15.17%
356.82
+216.68%
112.68
+253.33%
31.89
Cash Cash Equivalents And Short Term Investments
391.09
+11.45%
350.92
+296.60%
88.48
+189.09%
30.61
Cash And Cash Equivalents
120.72
-49.32%
238.20
+169.20%
88.48
+189.09%
30.61
Cash Equivalents
—
—
86.57
+192.41%
29.61
Cash Financial
—
—
1.91
+90.90%
1.00
Other Short Term Investments
270.37
+139.84%
112.73
0.00
—
Receivables
13.74
+1122.42%
1.12
-95.06%
22.78
0.00
Accounts Receivable
10.36
+5956.14%
0.17
+13.25%
0.15
0.00
Other Receivables
—
—
22.62
—
Accrued Interest Receivable
3.38
+255.09%
0.95
—
—
Prepaid Assets
4.98
+9.81%
4.54
+241.97%
1.33
+22.98%
1.08
Other Current Assets
1.15
+382.01%
0.24
+159.78%
0.09
-54.90%
0.20
Total Non Current Assets
185.22
+85.72%
99.73
+448.30%
18.19
+330.10%
4.23
Net PPE
25.93
-9.62%
28.69
+66.94%
17.19
+453.53%
3.10
Gross PPE
30.29
-4.23%
31.62
+68.12%
18.81
+381.91%
3.90
Accumulated Depreciation
-4.35
-48.58%
-2.93
-80.58%
-1.62
-103.26%
-0.80
Properties
0.00
0.00
0.00
0.00
Machinery Furniture Equipment
1.62
+0.00%
1.62
+74.33%
0.93
+303.03%
0.23
Construction In Progress
0.11
0.00
—
—
Other Properties
27.84
-4.93%
29.28
+67.43%
17.49
+376.28%
3.67
Leases
0.72
+0.00%
0.72
+84.32%
0.39
0.00
Investments And Advances
157.57
+125.53%
69.87
0.00
—
Other Non Current Assets
1.72
+46.84%
1.17
+16.97%
1.00
-10.85%
1.12
Total Liabilities Net Minority Interest
214.26
+486.90%
36.51
-78.43%
169.24
+110.71%
80.32
Current Liabilities
86.93
+576.56%
12.85
+85.84%
6.91
+24.73%
5.54
Payables And Accrued Expenses
16.38
+141.16%
6.79
+75.25%
3.88
+25.93%
3.08
Payables
10.28
+221.34%
3.20
+12.80%
2.84
-7.62%
3.07
Accounts Payable
10.28
+221.34%
3.20
+21.35%
2.64
-14.13%
3.07
Current Accrued Expenses
6.09
+69.70%
3.59
+245.95%
1.04
+17200.00%
0.01
Pensionand Other Post Retirement Benefit Plans Current
5.92
+43.50%
4.13
+39.78%
2.95
+73.15%
1.71
Total Tax Payable
—
0.00
-100.00%
0.20
0.00
Income Tax Payable
—
0.00
-100.00%
0.20
0.00
Current Debt And Capital Lease Obligation
2.21
+19.50%
1.85
—
0.71
Current Capital Lease Obligation
2.21
+19.50%
1.85
0.00
-100.00%
0.71
Current Deferred Liabilities
62.27
0.00
—
—
Current Deferred Revenue
62.27
0.00
—
—
Other Current Liabilities
0.15
+89.74%
0.08
-8.24%
0.09
+70.00%
0.05
Total Non Current Liabilities Net Minority Interest
127.33
+438.21%
23.66
-85.43%
162.33
+117.08%
74.78
Long Term Debt And Capital Lease Obligation
21.41
-9.36%
23.62
+88.01%
12.57
0.00
Long Term Capital Lease Obligation
21.41
-9.36%
23.62
+88.01%
12.57
0.00
Non Current Deferred Liabilities
105.92
0.00
—
—
Non Current Deferred Revenue
105.92
0.00
—
—
Other Non Current Liabilities
—
0.03
-93.96%
0.55
+557.83%
0.08
Preferred Securities Outside Stock Equity
—
0.00
-100.00%
149.22
+99.77%
74.69
Stockholders Equity
381.93
-9.08%
420.05
+1194.61%
-38.37
+13.18%
-44.20
Common Stock Equity
381.93
-9.08%
420.05
+1194.61%
-38.37
+13.18%
-44.20
Capital Stock
0.04
+2.27%
0.04
+1366.67%
0.00
+0.00%
0.00
Common Stock
0.04
+2.27%
0.04
+1366.67%
0.00
+0.00%
0.00
Preferred Stock
0.00
0.00
0.00
—
Share Issued
44.81
+0.86%
44.42
+5.76%
42.00
+0.00%
42.00
Ordinary Shares Number
44.81
+0.86%
44.42
+5.76%
42.00
+0.00%
42.00
Additional Paid In Capital
548.52
+1.89%
538.32
+6465.69%
8.20
+25.14%
6.55
Retained Earnings
-167.25
-41.29%
-118.37
-154.15%
-46.58
+8.24%
-50.76
Gains Losses Not Affecting Retained Earnings
0.62
+1001.79%
0.06
0.00
—
Other Equity Adjustments
0.62
+1001.79%
0.06
—
—
Total Equity Gross Minority Interest
381.93
-9.08%
420.05
+1194.61%
-38.37
+13.18%
-44.20
Total Capitalization
381.93
-9.08%
420.05
+1194.61%
-38.37
+13.18%
-44.20
Working Capital
324.03
-5.80%
343.98
+225.23%
105.76
+301.43%
26.35
Invested Capital
381.93
-9.08%
420.05
+1194.61%
-38.37
+13.18%
-44.20
Total Debt
23.62
-7.27%
25.48
+102.74%
12.57
+1669.86%
0.71
Capital Lease Obligations
23.62
-7.27%
25.48
+102.74%
12.57
+1669.86%
0.71
Net Tangible Assets
381.93
-9.08%
420.05
+1194.61%
-38.37
+13.18%
-44.20
Tangible Book Value
381.93
-9.08%
420.05
+1194.61%
-38.37
+13.18%
-44.20
Available For Sale Securities
157.57
+125.53%
69.87
—
—
Investmentin Financial Assets
157.57
+125.53%
69.87
0.00
—
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
110.19
+263.32%
-67.47
-74.24%
-38.72
-66.17%
-23.30
Cash Flow From Continuing Operating Activities
110.19
+263.32%
-67.47
-74.24%
-38.72
-66.17%
-23.30
Net Income From Continuing Operations
-48.88
+31.92%
-71.80
-1817.66%
4.18
+115.10%
-27.68
Depreciation Amortization Depletion
1.60
+14.49%
1.40
+65.21%
0.85
+46.97%
0.58
Depreciation And Amortization
1.60
+14.49%
1.40
+65.21%
0.85
+46.97%
0.58
Other Non Cash Items
2.16
+51.19%
1.43
+70.61%
0.84
+57.92%
0.53
Stock Based Compensation
8.48
+168.91%
3.15
+94.57%
1.62
+6.58%
1.52
Deferred Tax
0.00
+100.00%
-0.49
-200.00%
0.49
0.00
Deferred Income Tax
0.00
+100.00%
-0.49
-200.00%
0.49
0.00
Operating Gains Losses
-12.50
—
-47.62
—
Gain Loss On Sale Of PPE
—
—
0.03
0.00
Change In Working Capital
162.78
+65535.89%
0.25
-73.22%
0.93
-46.96%
1.75
Change In Receivables
-10.19
-50825.00%
-0.02
+86.75%
-0.15
0.00
Changes In Account Receivables
-10.19
-50825.00%
-0.02
+86.75%
-0.15
0.00
Change In Prepaid Assets
-3.78
+12.01%
-4.30
-3059.56%
-0.14
+86.73%
-1.02
Change In Payables And Accrued Expense
10.96
+155.70%
4.29
+135.81%
1.82
-41.35%
3.10
Change In Accrued Expense
4.36
+22.31%
3.56
+44.23%
2.47
+79.84%
1.37
Change In Payable
6.60
+813.28%
0.72
+210.72%
-0.65
-137.83%
1.73
Change In Account Payable
6.60
+813.28%
0.72
+210.72%
-0.65
-137.83%
1.73
Change In Other Working Capital
166.34
+37028.35%
0.45
+158.18%
-0.77
-34.38%
-0.57
Change In Other Current Assets
-0.55
-225.88%
-0.17
-203.03%
0.17
-32.38%
0.24
Investing Cash Flow
-229.35
-42.81%
-160.60
-825.97%
22.12
+1816.21%
-1.29
Cash Flow From Continuing Investing Activities
-229.35
-42.81%
-160.60
-825.97%
22.12
+1816.21%
-1.29
Net PPE Purchase And Sale
-0.52
+75.37%
-2.10
+26.93%
-2.88
-123.27%
-1.29
Purchase Of PPE
-0.52
+75.37%
-2.10
+26.93%
-2.88
-123.27%
-1.29
Capital Expenditure
-0.52
+75.37%
-2.10
+26.93%
-2.88
-123.27%
-1.29
Net Investment Purchase And Sale
-241.33
-33.25%
-181.12
0.00
—
Purchase Of Investment
-450.95
-111.33%
-213.39
0.00
—
Sale Of Investment
209.62
+549.57%
32.27
0.00
—
Net Other Investing Changes
12.50
-44.75%
22.62
-9.50%
25.00
—
Financing Cash Flow
1.69
-99.55%
377.78
+406.95%
74.52
+147.98%
30.05
Cash Flow From Continuing Financing Activities
1.69
-99.55%
377.78
+406.95%
74.52
+147.98%
30.05
Net Common Stock Issuance
-0.00
-100.00%
302.79
+30278800.00%
-0.00
—
Common Stock Payments
-0.00
+0.00%
-0.00
+0.00%
-0.00
—
Repurchase Of Capital Stock
-0.00
+0.00%
-0.00
+0.00%
-0.00
—
Proceeds From Stock Option Exercised
1.69
+3150.00%
0.05
0.00
-100.00%
0.08
Changes In Cash
-117.47
-178.47%
149.71
+158.49%
57.92
+960.98%
5.46
Beginning Cash Position
239.10
+167.49%
89.39
+184.05%
31.47
+20.99%
26.01
End Cash Position
121.63
-49.13%
239.10
+167.49%
89.39
+184.05%
31.47
Free Cash Flow
109.67
+257.63%
-69.57
-67.24%
-41.60
-69.16%
-24.59
Income Tax Paid Supplemental Data
0.00
-100.00%
0.23
+209.33%
0.07
0.00
Amortization Of Securities
-3.45
-144.54%
-1.41
0.00
—
Common Stock Issuance
0.00
-100.00%
302.79
0.00
—
Issuance Of Capital Stock
0.00
-100.00%
377.73
+406.88%
74.52
+148.66%
29.97
Net Preferred Stock Issuance
0.00
-100.00%
74.94
+0.56%
74.52
+148.66%
29.97
Preferred Stock Issuance
0.00
-100.00%
74.94
+0.56%
74.52
+148.66%
29.97
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

Trades
Date User Broker Pattern Type Position Size Entry Price Trade P&L Status
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