Symbols / SPRB $60.95 +1.48%
SPRB Chart
About
Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, including anhedonia, weight alterations, and altered sleeping patterns. In addition, the company develops SPR202 for the treatment of Congenital Adrenal Hyperplasia (CAH), a chronic and potentially life-threatening rare disease with no cure. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize various pharmaceutical compounds. It also has a collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize Tildacerfont for the treatment of CAH in Japan. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in South San Francisco, California.
Fundamentals
Scroll to Statements| Sector | Healthcare | Industry | Biotechnology | Market Cap | 65.24M |
| Enterprise Value | 35.46M | Income | -38.97M | Sales | — |
| Book/sh | 30.99 | Cash/sh | 35.65 | Dividend Yield | — |
| Payout | 0.00% | Employees | 8 | IPO | — |
| P/E | — | Forward P/E | -10.90 | PEG | — |
| P/S | — | P/B | 1.97 | P/C | — |
| EV/EBITDA | -1.24 | EV/Sales | — | Quick Ratio | 5.11 |
| Current Ratio | 5.17 | Debt/Eq | 1.73 | LT Debt/Eq | — |
| EPS (ttm) | -84.32 | EPS next Y | -5.59 | EPS Growth | — |
| Revenue Growth | — | Earnings | 2026-03-09 07:00 | ROA | -36.41% |
| ROE | -109.24% | ROIC | — | Gross Margin | 0.00% |
| Oper. Margin | 0.00% | Profit Margin | 0.00% | Shs Outstand | 1.07M |
| Shs Float | 908.77K | Short Float | 11.72% | Short Ratio | 2.87 |
| Short Interest | — | 52W High | 1951.88 | 52W Low | 7.00 |
| Beta | 3.82 | Avg Volume | 38.70K | Volume | 8.13K |
| Target Price | $198.25 | Recom | Strong_buy | Prev Close | $60.06 |
| Price | $60.95 | Change | 1.48% |
Valuation Models
Price estimates from analyst targets and simple models.
1. Analyst consensus
$198.25
Mean price target
2. Current target
$60.95
Latest analyst target
3. DCF / Fair value
$-280.32
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$60.95
Low
$140.00
High
$283.00
Mean
$198.25
Latest analyst rating changes
| Date | Action | Analyst | Rating Change | Price Target |
|---|---|---|---|---|
| 2026-03-10 | main | Citizens | Market Outperform → Market Outperform | $170 |
| 2026-03-10 | reit | HC Wainwright & Co. | Buy → Buy | $200 |
| 2026-02-19 | main | HC Wainwright & Co. | Buy → Buy | $200 |
| 2025-12-23 | init | Oppenheimer | — → Outperform | $283 |
| 2025-12-03 | up | Leerink Partners | Market Perform → Outperform | $160 |
| 2025-11-11 | main | Citizens | Market Outperform → Market Outperform | $259 |
| 2025-10-28 | up | JMP Securities | Market Perform → Market Outperform | $254 |
| 2025-10-21 | main | Leerink Partners | Market Perform → Market Perform | $160 |
| 2025-04-16 | main | RBC Capital | Sector Perform → Sector Perform | $1 |
| 2024-12-16 | reit | HC Wainwright & Co. | Neutral → Neutral | — |
| 2024-12-12 | reit | Guggenheim | Neutral → Neutral | — |
| 2024-12-11 | down | JMP Securities | Market Outperform → Market Perform | $3 |
| 2024-12-11 | reit | RBC Capital | Sector Perform → Sector Perform | $2 |
| 2024-12-11 | down | Oppenheimer | Outperform → Perform | — |
| 2024-11-12 | reit | RBC Capital | Sector Perform → Sector Perform | $2 |
| 2024-08-19 | reit | HC Wainwright & Co. | — → Neutral | — |
| 2024-08-13 | reit | RBC Capital | Sector Perform → Sector Perform | $2 |
| 2024-06-13 | main | Oppenheimer | Outperform → Outperform | $3 |
| 2024-06-05 | reit | HC Wainwright & Co. | — → Neutral | — |
| 2024-05-14 | reit | HC Wainwright & Co. | — → Neutral | — |
- Harbour BioMed Acquires Common Stock in Spruce Biosciences, Deepening Strategic Collaboration - PR Newswire Sun, 18 Jan 2026 08
- $SPRB stock is up 11% today. Here's what we see in our data. - Quiver Quantitative Mon, 09 Mar 2026 19
- Rare-disease launch veteran joins Spruce to ready TA-ERT therapy - Stock Titan Mon, 09 Mar 2026 11
- HC Wainwright Issues Optimistic Outlook for SPRB Earnings - MarketBeat hu, 12 Mar 2026 10
- What Makes Spruce Biosciences, Inc. (SPRB) a Strong Momentum Stock: Buy Now? - Yahoo Finance Wed, 15 Oct 2025 07
- SPRB Stock Drops After Company Pushes Back Application Submission Timeline For Experimental Sanfilippo Syndrome Therapy - Stocktwits Wed, 18 Feb 2026 19
- SPRB: Citizens Lowers Price Target but Maintains Market Outperfo - GuruFocus ue, 10 Mar 2026 13
- Oppenheimer Remains a Buy on Spruce Biosciences (SPRB) - The Globe and Mail Wed, 11 Mar 2026 12
- Spruce Biosciences (SPRB) Price Target Increased by 55.76% to 213.69 - Nasdaq Sat, 06 Dec 2025 08
- Spruce Biosciences CEO plans back-to-back Miami investor talks - Stock Titan Mon, 02 Mar 2026 08
- $SPRB stock is down 13% today. Here's what we see in our data. - Quiver Quantitative ue, 17 Feb 2026 08
- Spruce Biosciences (SPRB) Chief Commercial Officer files Form 3 - Stock Titan Mon, 09 Mar 2026 20
- Spruce Biosciences (NASDAQ: SPRB) trims 2025 loss, adds growth capital - Stock Titan Mon, 09 Mar 2026 11
- $SPRB stock is down 9% today. Here's what we see in our data. - Quiver Quantitative Fri, 28 Nov 2025 08
- Harbour BioMed buys into Spruce to back new hormone disorder drug - Stock Titan Sun, 18 Jan 2026 08
Insider Transactions
| Date | Shares | Value | Url | Text | Insider | Position | Transaction | Start Date | Ownership |
|---|---|---|---|---|---|---|---|---|---|
| 0 | 4690 | 408546.0 | — | Stock Award(Grant) at price 87.11 per share. | SZWARCBERG JAVIER B M.D. | Chief Executive Officer | — | 2025-12-31 00:00:00 | D |
| 1 | 1009 | nan | — | — | GHARIB SAMIR M | President | — | 2025-12-15 00:00:00 | D |
| 2 | 2676 | nan | — | — | SZWARCBERG JAVIER B M.D. | Chief Executive Officer | — | 2025-12-15 00:00:00 | D |
| 3 | 2414 | nan | — | — | GHARIB SAMIR M | President | — | 2025-12-11 00:00:00 | D |
| 4 | 1250 | nan | — | — | WAYS KIRK | Officer and Director | — | 2025-12-11 00:00:00 | D |
| 5 | 6146 | nan | — | — | SZWARCBERG JAVIER B M.D. | Chief Executive Officer | — | 2025-12-11 00:00:00 | D |
| 6 | 2053 | nan | — | — | GHARIB SAMIR M | President | — | 2025-10-20 00:00:00 | D |
| 7 | 4784 | nan | — | — | SZWARCBERG JAVIER B M.D. | Chief Executive Officer | — | 2025-10-20 00:00:00 | D |
| 8 | 256 | 33382.0 | — | Purchase at price 130.40 per share. | PARKMAN HEALTHCARE PARTNERS LLC | Beneficial Owner of more than 10% of a Class of Security | — | 2025-10-06 00:00:00 | I |
| 9 | 256 | 33382.0 | — | Purchase at price 130.40 per share. | PARKMAN HEALTHCARE PARTNERS LLC | Beneficial Owner of more than 10% of a Class of Security | — | 2025-10-06 00:00:00 | I |
Financials
| Line Item | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|
| TaxEffectOfUnusualItems | 0.00 | 0.00 | 0.00 | 0.00 |
| TaxRateForCalcs | 0.00 | 0.00 | 0.00 | 0.00 |
| NormalizedEBITDA | -52.68M | -47.37M | -45.69M | -41.88M |
| NetIncomeFromContinuingOperationNetMinorityInterest | -53.04M | -47.92M | -46.18M | -42.29M |
| ReconciledDepreciation | 46.00K | 70.00K | 74.00K | 68.00K |
| EBITDA | -52.68M | -47.37M | -45.69M | -41.88M |
| EBIT | -52.73M | -47.44M | -45.76M | -41.95M |
| NetInterestIncome | 3.12M | 4.07M | 1.10M | -226.00K |
| InterestExpense | 307.00K | 483.00K | 420.00K | 345.00K |
| InterestIncome | 3.42M | 4.56M | 1.52M | 119.00K |
| NormalizedIncome | -53.04M | -47.92M | -46.18M | -42.29M |
| NetIncomeFromContinuingAndDiscontinuedOperation | -53.04M | -47.92M | -46.18M | -42.29M |
| TotalExpenses | 61.06M | 62.08M | 47.28M | 42.07M |
| TotalOperatingIncomeAsReported | -56.15M | -51.99M | -47.28M | -42.07M |
| DilutedAverageShares | 550.20K | 513.47K | 313.69K | 311.49K |
| BasicAverageShares | 550.20K | 513.47K | 313.69K | 311.49K |
| DilutedEPS | -96.75 | -93.00 | -147.00 | -135.75 |
| BasicEPS | -96.75 | -93.00 | -147.00 | -135.75 |
| DilutedNIAvailtoComStockholders | -53.04M | -47.92M | -46.18M | -42.29M |
| NetIncomeCommonStockholders | -53.04M | -47.92M | -46.18M | -42.29M |
| NetIncome | -53.04M | -47.92M | -46.18M | -42.29M |
| NetIncomeIncludingNoncontrollingInterests | -53.04M | -47.92M | -46.18M | -42.29M |
| NetIncomeContinuousOperations | -53.04M | -47.92M | -46.18M | -42.29M |
| PretaxIncome | -53.04M | -47.92M | -46.18M | -42.29M |
| OtherIncomeExpense | 119.00K | |||
| OtherNonOperatingIncomeExpenses | 119.00K | |||
| NetNonOperatingInterestIncomeExpense | 3.12M | 4.07M | 1.10M | -226.00K |
| InterestExpenseNonOperating | 307.00K | 483.00K | 420.00K | 345.00K |
| InterestIncomeNonOperating | 3.42M | 4.56M | 1.52M | 119.00K |
| OperatingIncome | -56.15M | -51.99M | -47.28M | -42.07M |
| OperatingExpense | 61.06M | 62.08M | 47.28M | 42.07M |
| ResearchAndDevelopment | 46.42M | 49.43M | 35.20M | 30.70M |
| SellingGeneralAndAdministration | 14.64M | 12.65M | 12.09M | 11.37M |
| GeneralAndAdministrativeExpense | 14.64M | 12.65M | 12.09M | 11.37M |
| OtherGandA | 14.64M | 12.65M | 12.09M | 11.37M |
| TotalRevenue | 4.91M | 10.09M | 0.00 | 0.00 |
| OperatingRevenue | 4.91M | 10.09M | 0.00 | 0.00 |
| Line Item | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|
| OrdinarySharesNumber | 563.08K | 547.06K | 314.68K | 313.23K |
| ShareIssued | 563.08K | 547.06K | 314.68K | 313.23K |
| TotalDebt | 2.77M | 4.61M | 6.32M | 6.53M |
| TangibleBookValue | 28.82M | 76.51M | 68.49M | 111.37M |
| InvestedCapital | 30.57M | 79.85M | 73.40M | 116.25M |
| WorkingCapital | 28.96M | 77.72M | 71.16M | 83.02M |
| NetTangibleAssets | 28.82M | 76.51M | 68.49M | 111.37M |
| CapitalLeaseObligations | 1.02M | 1.27M | 1.40M | 1.65M |
| CommonStockEquity | 28.82M | 76.51M | 68.49M | 111.37M |
| TotalCapitalization | 28.95M | 78.23M | 71.78M | 116.25M |
| TotalEquityGrossMinorityInterest | 28.82M | 76.51M | 68.49M | 111.37M |
| StockholdersEquity | 28.82M | 76.51M | 68.49M | 111.37M |
| GainsLossesNotAffectingRetainedEarnings | 0.00 | -558.00K | -184.00K | |
| OtherEquityAdjustments | -558.00K | -184.00K | ||
| RetainedEarnings | -250.27M | -197.23M | -149.31M | -103.13M |
| AdditionalPaidInCapital | 279.08M | 273.74M | 218.35M | 214.69M |
| CapitalStock | 4.00K | 4.00K | 3.00K | 3.00K |
| CommonStock | 4.00K | 4.00K | 3.00K | 3.00K |
| PreferredStock | 0.00 | 0.00 | 0.00 | 0.00 |
| TotalLiabilitiesNetMinorityInterest | 16.39M | 27.44M | 17.16M | 15.12M |
| TotalNonCurrentLiabilitiesNetMinorityInterest | 1.14M | 2.97M | 4.71M | 6.24M |
| OtherNonCurrentLiabilities | 282.00K | 236.00K | 161.00K | 73.00K |
| LongTermDebtAndCapitalLeaseObligation | 860.00K | 2.74M | 4.55M | 6.17M |
| LongTermCapitalLeaseObligation | 736.00K | 1.02M | 1.26M | 1.29M |
| LongTermDebt | 124.00K | 1.72M | 3.29M | 4.88M |
| CurrentLiabilities | 15.25M | 24.46M | 12.45M | 8.87M |
| CurrentDeferredLiabilities | 0.00 | 4.91M | 0.00 | |
| CurrentDeferredRevenue | 0.00 | 4.91M | 0.00 | |
| CurrentDebtAndCapitalLeaseObligation | 1.91M | 1.87M | 1.76M | 360.00K |
| CurrentCapitalLeaseObligation | 283.00K | 251.00K | 139.00K | 360.00K |
| CurrentDebt | 1.62M | 1.62M | 1.62M | |
| OtherCurrentBorrowings | 1.62M | 1.62M | 1.62M | |
| PensionandOtherPostRetirementBenefitPlansCurrent | 882.00K | 3.10M | 1.29M | 1.44M |
| PayablesAndAccruedExpenses | 12.46M | 14.58M | 9.40M | 7.08M |
| CurrentAccruedExpenses | 11.16M | 11.25M | 7.97M | 4.25M |
| Payables | 1.29M | 3.33M | 1.43M | 2.82M |
| AccountsPayable | 1.29M | 3.33M | 1.43M | 2.82M |
| TotalAssets | 45.21M | 103.95M | 85.65M | 126.49M |
| TotalNonCurrentAssets | 1.00M | 1.76M | 2.04M | 34.59M |
| OtherNonCurrentAssets | 69.00K | 582.00K | 640.00K | 653.00K |
| InvestmentsAndAdvances | 0.00 | 32.46M | ||
| NetPPE | 934.00K | 1.18M | 1.40M | 1.48M |
| GrossPPE | 934.00K | 1.18M | 1.40M | 1.48M |
| OtherProperties | 934.00K | 1.18M | 1.40M | 1.48M |
| CurrentAssets | 44.21M | 102.18M | 83.61M | 91.89M |
| OtherCurrentAssets | 2.28M | 1.97M | 1.21M | 396.00K |
| PrepaidAssets | 3.18M | 3.88M | 3.32M | 2.53M |
| CashCashEquivalentsAndShortTermInvestments | 38.75M | 96.34M | 79.08M | 88.97M |
| OtherShortTermInvestments | 0.00 | 54.59M | 46.22M | |
| CashAndCashEquivalents | 38.75M | 96.34M | 24.49M | 42.75M |
| Line Item | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|
| FreeCashFlow | -55.96M | -33.28M | -41.69M | -35.97M |
| RepaymentOfDebt | -1.62M | -1.62M | 0.00 | -4.77M |
| IssuanceOfDebt | 0.00 | 4.99M | ||
| IssuanceOfCapitalStock | 0.00 | 53.62M | 0.00 | 0.00 |
| CapitalExpenditure | -7.00K | -8.00K | -93.00K | |
| InterestPaidSupplementalData | 225.00K | 369.00K | 266.00K | 207.00K |
| EndCashPosition | 38.79M | 96.37M | 24.73M | 42.96M |
| BeginningCashPosition | 96.37M | 24.73M | 42.96M | 157.37M |
| ChangesInCash | -57.59M | 71.64M | -18.23M | -114.40M |
| FinancingCashFlow | -1.62M | 49.14M | -241.00K | 643.00K |
| CashFlowFromContinuingFinancingActivities | -1.62M | 49.14M | -241.00K | 643.00K |
| NetOtherFinancingCharges | -246.00K | -3.03M | -319.00K | -39.00K |
| ProceedsFromStockOptionExercised | 246.00K | 178.00K | 78.00K | 462.00K |
| NetPreferredStockIssuance | 0.00 | |||
| PreferredStockIssuance | 0.00 | |||
| NetCommonStockIssuance | 0.00 | 53.62M | 0.00 | 0.00 |
| CommonStockIssuance | 0.00 | 53.62M | 0.00 | 0.00 |
| NetIssuancePaymentsOfDebt | -1.62M | -1.62M | 0.00 | 220.00K |
| NetLongTermDebtIssuance | -1.62M | -1.62M | 0.00 | 220.00K |
| LongTermDebtPayments | -1.62M | -1.62M | 0.00 | -4.77M |
| LongTermDebtIssuance | 0.00 | 4.99M | ||
| InvestingCashFlow | 0.00 | 55.78M | 23.69M | -79.17M |
| CashFlowFromContinuingInvestingActivities | 0.00 | 55.78M | 23.69M | -79.17M |
| NetInvestmentPurchaseAndSale | 0.00 | 55.78M | 23.70M | -79.08M |
| SaleOfInvestment | 0.00 | 67.67M | 60.50M | 0.00 |
| PurchaseOfInvestment | 0.00 | -11.88M | -36.80M | -79.08M |
| NetPPEPurchaseAndSale | 0.00 | -7.00K | -8.00K | -93.00K |
| PurchaseOfPPE | 0.00 | -7.00K | -8.00K | -93.00K |
| OperatingCashFlow | -55.96M | -33.27M | -41.68M | -35.88M |
| CashFlowFromContinuingOperatingActivities | -55.96M | -33.27M | -41.68M | -35.88M |
| ChangeInWorkingCapital | -8.57M | 10.36M | 1.13M | 1.96M |
| ChangeInOtherWorkingCapital | -4.91M | 4.91M | 350.00K | |
| ChangeInOtherCurrentLiabilities | -237.00K | -176.00K | -331.00K | -156.00K |
| ChangeInOtherCurrentAssets | 494.00K | 96.00K | 90.00K | 197.00K |
| ChangeInPayablesAndAccruedExpense | -4.31M | 8.16M | 2.19M | 1.50M |
| ChangeInAccruedExpense | -2.27M | 6.25M | 3.59M | 2.30M |
| ChangeInPayable | -2.04M | 1.91M | -1.40M | -805.00K |
| ChangeInAccountPayable | -2.04M | 1.91M | -1.40M | -805.00K |
| ChangeInPrepaidAssets | 391.00K | -2.64M | -817.00K | 415.00K |
| OtherNonCashItems | 247.00K | 230.00K | -395.00K | 313.00K |
| StockBasedCompensation | 5.35M | 4.62M | 3.63M | 3.96M |
| AmortizationOfSecurities | 0.00 | -636.00K | 16.00K | 121.00K |
| DepreciationAmortizationDepletion | 46.00K | 70.00K | 74.00K | 68.00K |
| DepreciationAndAmortization | 46.00K | 70.00K | 74.00K | 68.00K |
| OperatingGainsLosses | 2.00K | 2.00K | 39.00K | |
| GainLossOnSaleOfPPE | 2.00K | 2.00K | 39.00K | 0.00 |
| NetIncomeFromContinuingOperations | -53.04M | -47.92M | -46.18M | -42.29M |
SEC Filings
Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.
Public Trades for SPRB
| Date | User | Broker | Pattern | Type | Position Size | Entry Price | Trade P&L | Status |
|---|