Symbols / SPRO $2.61 +7.41% Spero Therapeutics, Inc.

Healthcare • Biotechnology • United States • NMS
SPRO Chart
About

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which is in Phase 3 development; and SPR720, a novel product candidate for first-line treatment of nontuberculous mycobacterial (NTM) pulmonary disease. It has license agreement with Meiji Seika Pharma Co., Ltd. to support the development of tebipenem HBr; Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries; and Vertex Pharmaceuticals Incorporated for patents relating to the oral prodrug SPR720, as well as SPR719, an active metabolite. Spero Therapeutics, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.

Fundamentals
Scroll to Statements
Sector Healthcare Industry Biotechnology Market Cap 151.10M
Enterprise Value 103.31M Income 8.57M Sales 66.80M
Book/sh 1.05 Cash/sh 0.70 Dividend Yield —
Payout 0.00% Employees — IPO —
P/E 17.40 Forward P/E -2.35 PEG —
P/S 2.26 P/B 2.50 P/C —
EV/EBITDA 14.43 EV/Sales 1.55 Quick Ratio 7.40
Current Ratio 7.59 Debt/Eq 4.91 LT Debt/Eq —
EPS (ttm) 0.15 EPS next Y -1.11 EPS Growth —
Revenue Growth 174.50% Earnings 2026-05-13 ROA 4.99%
ROE 16.30% ROIC — Gross Margin 42.42%
Oper. Margin 76.05% Profit Margin 12.83% Shs Outstand 57.89M
Shs Float 47.33M Short Float 1.16% Short Ratio 1.73
Short Interest — 52W High 3.22 52W Low 0.51
Beta 1.45 Avg Volume 314.19K Volume 470.62K
Target Price $4.00 Recom None Prev Close $2.43
Price $2.61 Change 7.41%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$4.00
Mean price target
2. Current target
$2.61
Latest analyst target
3. DCF / Fair value
$-1.32
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$2.61
Low
$4.00
High
$4.00
Mean
$4.00

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2025-01-30 reit HC Wainwright & Co. Buy → Buy $5
2024-12-20 down Evercore ISI Group Outperform → In-Line $5
2024-12-02 reit HC Wainwright & Co. Buy → Buy $5
2024-11-18 down TD Cowen Buy → Hold —
2024-11-15 reit Cantor Fitzgerald — → Overweight —
2024-11-04 main HC Wainwright & Co. Buy → Buy $5
2024-10-03 reit HC Wainwright & Co. Buy → Buy $7
2024-08-06 up TD Cowen Hold → Buy —
2024-08-06 reit Cantor Fitzgerald — → Overweight —
2024-08-06 reit HC Wainwright & Co. Buy → Buy $7
2024-05-16 reit HC Wainwright & Co. Buy → Buy $7
2024-04-04 reit Cantor Fitzgerald — → Overweight —
2024-03-18 reit HC Wainwright & Co. Buy → Buy $7
2023-11-14 reit HC Wainwright & Co. Buy → Buy $7
2023-09-05 reit HC Wainwright & Co. Buy → Buy $7
2023-08-14 main HC Wainwright & Co. Buy → Buy $7
2023-08-01 reit HC Wainwright & Co. Buy → Buy $6
2023-07-20 reit HC Wainwright & Co. Buy → Buy $6
2023-04-10 reit HC Wainwright & Co. — → Buy $6
2022-09-26 main HC Wainwright & Co. — → Buy $6
News
RSS: Latest SPRO news
Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2026-02-06 KEUTZER TIMOTHY Chief Operating Officer — 18,652 $2.36 $44,019
2026-02-06 RAJAVELU ESTHER Chief Executive Officer — 87,917 $2.36 $207,484
2026-02-04 KEUTZER TIMOTHY Chief Operating Officer — 46,586 $2.14 $101,175
2026-02-02 RAJAVELU ESTHER Chief Executive Officer — 18,442 $2.20 $40,572
2026-02-02 KEUTZER TIMOTHY Chief Operating Officer — 68,000 $0.00 $0
2026-02-02 RAJAVELU ESTHER Chief Executive Officer — 249,000 $0.00 $0
2025-11-07 RAJAVELU ESTHER Chief Executive Officer — 40,270 $2.37 $95,440
2025-08-28 MAHADEVIA ANKIT Director — 6,572 $1.97 $12,947
2025-08-28 KEUTZER TIMOTHY Chief Operating Officer — 1,695 $1.97 $3,339
2025-06-12 MAHADEVIA ANKIT Director — 20,000 $0.00 $0
Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
59.62
+117.62%
27.40
-71.68%
96.73
+99.13%
48.58
Operating Revenue
59.62
+117.62%
27.40
-71.68%
96.73
+99.13%
48.58
Operating Expense
52.46
-47.48%
99.88
+42.79%
69.95
-11.62%
79.15
Research And Development
38.47
-60.24%
96.76
+88.10%
51.44
+8.08%
47.59
Selling General And Administration
21.18
-10.66%
23.70
-7.24%
25.55
-29.96%
36.48
General And Administrative Expense
21.18
-10.66%
23.70
-7.24%
25.55
-29.96%
36.48
Salaries And Wages
11.79
-10.59%
13.19
-13.94%
15.32
-25.00%
20.43
Other Gand A
9.38
-10.76%
10.52
+2.80%
10.23
-36.26%
16.05
Other Operating Expenses
-7.18
+65.10%
-20.58
-192.09%
-7.05
-42.92%
-4.93
Total Expenses
52.46
-47.48%
99.88
+42.79%
69.95
-11.62%
79.15
Operating Income
7.16
+109.88%
-72.48
-370.59%
26.79
+187.63%
-30.57
Total Operating Income As Reported
6.31
+108.61%
-73.36
-441.52%
21.48
+150.91%
-42.20
EBITDA
7.16
+109.88%
-72.48
-366.93%
27.15
+163.24%
-42.94
Normalized EBITDA
8.00
+111.18%
-71.61
-320.59%
32.46
+200.72%
-32.23
Reconciled Depreciation
0.00
-100.00%
0.00
-99.46%
0.37
-57.77%
0.87
EBIT
7.16
+109.88%
-72.48
-370.59%
26.79
+161.14%
-43.81
Total Unusual Items
-0.84
+3.65%
-0.88
+83.47%
-5.31
+50.47%
-10.71
Total Unusual Items Excluding Goodwill
-0.84
+3.65%
-0.88
+83.47%
-5.31
+50.47%
-10.71
Special Income Charges
-0.84
+3.65%
-0.88
+83.47%
-5.31
+54.38%
-11.63
Other Special Charges
—
—
—
3.58
Impairment Of Capital Assets
—
0.00
-100.00%
5.31
0.00
Restructuring And Mergern Acquisition
0.26
-70.58%
0.88
0.00
-100.00%
11.63
Write Off
0.59
0.00
-100.00%
5.31
0.00
Net Income
8.57
+112.50%
-68.57
-400.65%
22.81
+149.13%
-46.41
Pretax Income
8.83
+112.88%
-68.57
-369.90%
25.40
+154.73%
-46.41
Net Non Operating Interest Income Expense
2.51
-46.95%
4.74
+20.27%
3.94
+362.64%
-1.50
Interest Expense Non Operating
—
—
0.00
-100.00%
2.60
Net Interest Income
2.51
-46.95%
4.74
+20.27%
3.94
+362.64%
-1.50
Interest Expense
—
—
0.00
-100.00%
2.60
Interest Income Non Operating
2.51
-46.95%
4.74
+20.27%
3.94
+255.97%
1.11
Interest Income
2.51
-46.95%
4.74
+20.27%
3.94
+255.97%
1.11
Other Income Expense
-0.84
-2.57%
-0.82
+84.64%
-5.32
+62.92%
-14.35
Other Non Operating Income Expenses
0.01
-88.33%
0.06
+528.57%
-0.01
+99.61%
-3.64
Gain On Sale Of Security
—
—
—
0.92
Tax Provision
0.26
0.00
-100.00%
2.60
0.00
Tax Rate For Calcs
0.00
0.00
-100.00%
0.00
0.00
Tax Effect Of Unusual Items
-0.02
0.00
+100.00%
-0.54
0.00
Net Income Including Noncontrolling Interests
8.57
+112.50%
-68.57
-400.65%
22.81
+149.13%
-46.41
Net Income From Continuing Operation Net Minority Interest
8.57
+112.50%
-68.57
-400.65%
22.81
+149.13%
-46.41
Net Income From Continuing And Discontinued Operation
8.57
+112.50%
-68.57
-400.65%
22.81
+149.13%
-46.41
Net Income Continuous Operations
8.57
+112.50%
-68.57
-400.65%
22.81
+149.13%
-46.41
Normalized Income
9.39
+113.88%
-67.69
-345.51%
27.57
+177.22%
-35.70
Net Income Common Stockholders
8.57
+112.50%
-68.57
-400.65%
22.81
+149.13%
-46.41
Diluted EPS
0.15
+111.81%
-1.27
-395.35%
0.43
+134.96%
-1.23
Basic EPS
0.15
+111.81%
-1.27
-395.35%
0.43
+134.96%
-1.23
Basic Average Shares
56.02
+3.67%
54.04
+2.53%
52.70
+40.22%
37.59
Diluted Average Shares
59.04
+9.26%
54.04
+1.98%
52.99
+40.98%
37.59
Diluted NI Availto Com Stockholders
8.57
+112.50%
-68.57
-400.65%
22.81
+149.13%
-46.41
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Assets
68.92
-37.65%
110.54
-39.39%
182.39
+46.14%
124.80
Current Assets
67.29
-37.28%
107.28
-18.24%
131.21
+15.53%
113.57
Cash Cash Equivalents And Short Term Investments
40.27
-23.87%
52.89
-30.71%
76.33
-30.04%
109.11
Cash And Cash Equivalents
40.27
-23.87%
52.89
-30.71%
76.33
-30.04%
109.11
Cash Equivalents
39.67
-24.08%
52.26
—
—
Cash Financial
0.59
-6.02%
0.63
—
—
Other Short Term Investments
—
—
—
0.00
Receivables
25.39
-51.62%
52.48
+3.51%
50.70
+4576.85%
1.08
Other Receivables
0.03
-99.09%
3.08
+99.68%
1.54
+42.53%
1.08
Taxes Receivable
—
—
—
—
Prepaid Assets
—
—
—
—
Other Current Assets
1.63
-14.50%
1.91
-54.26%
4.18
+23.65%
3.38
Total Non Current Assets
1.63
-50.02%
3.27
-93.62%
51.18
+355.68%
11.23
Net PPE
1.48
-52.47%
3.11
-25.09%
4.16
-24.31%
5.49
Gross PPE
1.48
-52.47%
3.11
-59.95%
7.78
-11.08%
8.74
Accumulated Depreciation
—
-3.62
-0.06%
-3.62
-11.25%
-3.25
Properties
—
0.00
0.00
0.00
Machinery Furniture Equipment
—
0.65
+0.00%
0.65
+0.00%
0.65
Construction In Progress
—
—
—
—
Other Properties
1.48
-52.47%
3.11
-43.31%
5.49
-15.00%
6.46
Leases
—
1.64
+0.00%
1.64
+0.00%
1.64
Non Current Accounts Receivable
—
—
46.59
—
Other Non Current Assets
0.15
+0.00%
0.15
-64.83%
0.43
-92.42%
5.74
Total Liabilities Net Minority Interest
9.90
-84.64%
64.42
-14.67%
75.50
+54.49%
48.87
Current Liabilities
8.87
-81.93%
49.07
+32.09%
37.15
+71.62%
21.65
Payables And Accrued Expenses
6.65
-73.60%
25.20
+202.86%
8.32
-13.22%
9.59
Payables
1.08
-85.61%
7.48
+323.80%
1.76
+186.06%
0.62
Accounts Payable
0.69
-90.51%
7.31
+430.19%
1.38
+123.34%
0.62
Current Accrued Expenses
5.58
-68.53%
17.72
+170.31%
6.56
-26.93%
8.97
Total Tax Payable
0.38
+120.11%
0.17
-55.04%
0.39
0.00
Income Tax Payable
0.38
+120.11%
0.17
-55.04%
0.39
0.00
Current Debt And Capital Lease Obligation
1.96
+12.03%
1.75
+1.63%
1.72
+1.66%
1.69
Current Capital Lease Obligation
1.96
+12.03%
1.75
+1.63%
1.72
+1.66%
1.69
Current Deferred Liabilities
0.26
-98.83%
22.12
-18.40%
27.11
+161.48%
10.37
Current Deferred Revenue
0.26
-98.83%
22.12
-18.40%
27.11
+161.48%
10.37
Total Non Current Liabilities Net Minority Interest
1.03
-93.29%
15.35
-59.98%
38.34
+40.87%
27.22
Long Term Debt And Capital Lease Obligation
0.94
-63.19%
2.55
-33.31%
3.83
-22.84%
4.96
Long Term Capital Lease Obligation
0.94
-63.19%
2.55
-33.31%
3.83
-22.84%
4.96
Non Current Deferred Liabilities
0.00
-100.00%
12.22
+12.88%
10.82
+11.13%
9.74
Non Current Deferred Revenue
0.00
-100.00%
12.22
+12.88%
10.82
+11.13%
9.74
Other Non Current Liabilities
0.09
—
0.09
-9.38%
0.10
Stockholders Equity
59.02
+27.96%
46.12
-56.85%
106.89
+40.77%
75.93
Common Stock Equity
59.02
+27.96%
46.12
-56.85%
106.89
+40.77%
75.93
Capital Stock
0.06
+1.82%
0.06
+3.77%
0.05
+1.92%
0.05
Common Stock
0.06
+1.82%
0.06
+3.77%
0.05
+1.92%
0.05
Preferred Stock
0.00
0.00
0.00
0.00
Share Issued
56.41
+3.34%
54.59
+3.01%
53.00
+1.04%
52.46
Ordinary Shares Number
56.41
+3.34%
54.59
+3.01%
53.00
+1.04%
52.46
Additional Paid In Capital
510.03
+0.86%
505.71
+1.57%
497.91
+1.66%
489.76
Retained Earnings
-451.07
+1.86%
-459.64
-17.53%
-391.07
+5.51%
-413.88
Gains Losses Not Affecting Retained Earnings
—
—
0.00
0.00
Other Equity Adjustments
—
—
—
—
Total Equity Gross Minority Interest
59.02
+27.96%
46.12
-56.85%
106.89
+40.77%
75.93
Total Capitalization
59.02
+27.96%
46.12
-56.85%
106.89
+40.77%
75.93
Working Capital
58.42
+0.37%
58.20
-38.12%
94.06
+2.32%
91.92
Invested Capital
59.02
+27.96%
46.12
-56.85%
106.89
+40.77%
75.93
Total Debt
2.90
-32.63%
4.30
-22.48%
5.54
-16.61%
6.65
Capital Lease Obligations
2.90
-32.63%
4.30
-22.48%
5.54
-16.61%
6.65
Net Tangible Assets
59.02
+27.96%
46.12
-56.85%
106.89
+40.77%
75.93
Tangible Book Value
59.02
+27.96%
46.12
-56.85%
106.89
+40.77%
75.93
Derivative Product Liabilities
0.00
-100.00%
0.58
-97.56%
23.61
+89.99%
12.43
Duefrom Related Parties Current
25.36
-48.66%
49.39
+0.49%
49.15
0.00
Duefrom Related Parties Non Current
—
0.00
-100.00%
46.59
—
Preferred Stock Equity
—
—
—
—
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
-12.62
+46.15%
-23.44
+28.95%
-32.99
-326.79%
-7.73
Cash Flow From Continuing Operating Activities
-12.62
+46.15%
-23.44
+28.95%
-32.99
-326.79%
-7.73
Net Income From Continuing Operations
8.57
+112.50%
-68.57
-400.65%
22.81
+149.13%
-46.41
Depreciation Amortization Depletion
0.00
-100.00%
0.00
-99.46%
0.37
-57.77%
0.87
Depreciation And Amortization
0.00
-100.00%
0.00
-99.46%
0.37
-57.77%
0.87
Other Non Cash Items
1.05
+0.48%
1.04
+7.64%
0.97
-70.48%
3.28
Stock Based Compensation
4.33
-44.50%
7.79
-1.75%
7.93
-13.05%
9.12
Asset Impairment Charge
0.59
0.00
-100.00%
5.31
+735.59%
0.64
Operating Gains Losses
—
—
—
2.67
Gain Loss On Investment Securities
—
—
—
-0.92
Net Foreign Currency Exchange Gain Loss
—
—
0.00
-100.00%
0.01
Change In Working Capital
-27.16
-174.84%
36.28
+151.56%
-70.38
-418.63%
22.09
Change In Receivables
3.06
+298.51%
-1.54
-234.06%
-0.46
-129.80%
1.55
Change In Prepaid Assets
0.28
-87.78%
2.27
+383.73%
-0.80
-115.24%
5.24
Change In Payables And Accrued Expense
-18.55
-209.88%
16.88
+1431.39%
-1.27
+78.37%
-5.86
Change In Accrued Expense
-12.15
-208.77%
11.17
+562.21%
-2.42
+55.07%
-5.38
Change In Payable
-6.40
-212.06%
5.71
+397.82%
1.15
+337.19%
-0.48
Change In Account Payable
-6.61
-211.56%
5.93
+678.98%
0.76
+257.23%
-0.48
Change In Other Working Capital
-34.66
-30.18%
-26.62
-191.78%
29.01
+32.51%
21.89
Change In Other Current Assets
24.03
-48.47%
46.63
+148.71%
-95.74
-3191333.33%
-0.00
Change In Other Current Liabilities
-1.31
+1.65%
-1.33
-19.77%
-1.11
-52.47%
-0.73
Investing Cash Flow
—
—
0.00
-100.00%
33.81
Cash Flow From Continuing Investing Activities
—
—
0.00
-100.00%
33.81
Net PPE Purchase And Sale
—
—
—
—
Sale Of PPE
—
—
—
—
Net Investment Purchase And Sale
—
—
0.00
-100.00%
33.81
Purchase Of Investment
—
—
0.00
+100.00%
-26.97
Sale Of Investment
—
—
0.00
-100.00%
60.78
Net Other Investing Changes
—
—
—
—
Financing Cash Flow
—
0.00
-100.00%
0.22
+100.75%
-29.55
Cash Flow From Continuing Financing Activities
—
0.00
-100.00%
0.22
+100.75%
-29.55
Net Common Stock Issuance
—
0.00
-100.00%
0.22
-99.10%
24.51
Proceeds From Stock Option Exercised
—
—
0.00
-100.00%
0.42
Net Other Financing Charges
—
—
—
-54.48
Changes In Cash
-12.62
+46.15%
-23.44
+28.47%
-32.77
-842.59%
-3.48
Beginning Cash Position
52.89
-30.71%
76.33
-30.04%
109.11
-3.09%
112.58
End Cash Position
40.27
-23.87%
52.89
-30.71%
76.33
-30.04%
109.11
Free Cash Flow
-12.62
+46.15%
-23.44
+28.95%
-32.99
-326.79%
-7.73
Income Tax Paid Supplemental Data
—
0.10
-95.52%
2.21
0.00
Amortization Of Securities
—
—
0.00
-100.00%
0.01
Change In Income Tax Payable
0.21
+198.12%
-0.21
-155.04%
0.39
0.00
Change In Tax Payable
0.21
+198.12%
-0.21
-155.04%
0.39
0.00
Common Stock Issuance
—
0.00
-100.00%
0.22
-99.10%
24.51
Issuance Of Capital Stock
—
0.00
-100.00%
0.22
-99.10%
24.51
Net Preferred Stock Issuance
—
—
—
—
Preferred Stock Issuance
—
—
—
—
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

Trades
Date User Broker Pattern Type Position Size Entry Price Trade P&L Status
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