Symbols / SYRE Stock $69.24 -5.15% Spyre Therapeutics, Inc.

Healthcare • Biotechnology • United States • NMS
SYRE (Stock) Chart
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About

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Stock Fundamentals
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Market Cap 5.97B Enterprise Value 4.84B Income -126.54M Sales — Book/sh 7.16 Cash/sh 9.63
Dividend Yield — Payout — Employees 102 IPO — P/E — Forward P/E -22.92
PEG — P/S — P/B 9.68 P/C — EV/EBITDA — EV/Sales —
Quick Ratio 12.94 Current Ratio 13.25 Debt/Eq — LT Debt/Eq — EPS (ttm) -1.98 EPS next Y -3.02
EPS Growth — Revenue Growth — Earnings 2026-05-05 ROA -19.80% ROE -25.17% ROIC —
Gross Margin 0.00% Oper. Margin 0.00% Profit Margin 0.00% Shs Outstand 86.26M Shs Float 73.12M Short Float 14.33%
Short Ratio 12.56 Short Interest — 52W High 75.00 52W Low 12.29 Beta 2.94 Avg Volume 968.43K
Volume 659.91K Target Price $90.13 Recom Strong_buy Prev Close $73.00 Price $69.24 Change -5.15%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
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Mean price target
2. Current target
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Latest analyst target
3. DCF / Fair value
$-21.67
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
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News
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Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2026-04-01 TURTLE CAMERON Chief Executive Officer — 15,000 $49.20 $739,912
2026-04-01 BURROWS SCOTT L. Chief Financial Officer — 7,500 $49.21 $370,076
2026-04-01 BURROWS SCOTT L. Chief Financial Officer — 7,500 $14.50 $108,750
2026-04-01 SLOAN SHELDON Officer — 7,958 $50.00 $397,900
2026-04-01 SLOAN SHELDON Officer — 7,958 $21.66 $172,370
2026-03-03 BURROWS SCOTT L. Chief Financial Officer — 2,500 $40.56 $101,620
2026-03-03 BURROWS SCOTT L. Chief Financial Officer — 2,500 $14.50 $36,250
2026-03-02 TURTLE CAMERON Chief Executive Officer — 15,000 $41.73 $632,866
2026-02-02 TURTLE CAMERON Chief Executive Officer — 15,000 $31.82 $492,045
2026-01-02 TURTLE CAMERON Chief Executive Officer — 15,000 $30.47 $460,134
Financials

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SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

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