Symbols / UPB Stock $9.64 +4.10% Upstream Bio, Inc.

Healthcare • Biotechnology • United States • NMS
UPB (Stock) Chart
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About

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Fundamentals
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Market Cap 524.61M Enterprise Value 184.37M Income -143.44M Sales 2.85M Book/sh 6.26 Cash/sh 6.28
Dividend Yield — Payout 0.00% Employees 75 IPO — P/E — Forward P/E -2.99
PEG — P/S 183.82 P/B 1.54 P/C — EV/EBITDA -1.15 EV/Sales 64.60
Quick Ratio 25.56 Current Ratio 26.15 Debt/Eq 0.37 LT Debt/Eq — EPS (ttm) -2.66 EPS next Y -3.23
EPS Growth — Revenue Growth 9.00% Earnings 2026-05-05 ROA -23.99% ROE -35.44% ROIC —
Gross Margin 100.00% Oper. Margin -69.11% Profit Margin 0.00% Shs Outstand 54.42M Shs Float 34.59M Short Float 11.31%
Short Ratio 3.32 Short Interest — 52W High 33.68 52W Low 7.25 Beta — Avg Volume 1.32M
Volume 607.43K Target Price $43.57 Recom Strong_buy Prev Close $9.26 Price $9.64 Change 4.10%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
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Mean price target
2. Current target
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Latest analyst target
3. DCF / Fair value
$-29.36
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
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News
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Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2026-03-16 GRAY MICHAEL P Chief Operating Officer — 852 $9.29 $7,915
2026-03-16 SUTHERLAND EVERETT RAND Chief Executive Officer — 2,093 $9.29 $19,444
2026-03-16 HOUGHTON ADAM Officer — 699 $9.29 $6,494
2026-03-16 DEYKIN AARON M.D. Officer — 894 $9.29 $8,305
2026-03-16 AMBROSE ALLISON General Counsel — 475 $9.29 $4,413
2026-01-02 GRAY MICHAEL P Chief Operating Officer — 30,500 $0.00 $0
2026-01-02 SUTHERLAND EVERETT RAND Chief Executive Officer — 75,000 $0.00 $0
2026-01-02 HOUGHTON ADAM Officer — 25,000 $0.00 $0
2026-01-02 DEYKIN AARON M.D. Officer — 32,000 $0.00 $0
2026-01-02 AMBROSE ALLISON General Counsel — 17,000 $0.00 $0
Financials

No financial statements available. Data is sourced from Yahoo Finance and cached; historical storage may be added later.

SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

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