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About

X4 Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the research, development, and commercialization of novel therapeutics for the treatment of rare diseases of the immune system. It offers XOLREMDI, an orally bioavailable selective antagonist of chemokine receptor C-X-C chemokine receptor type 4 (CXCR4) for the treatment of patients with warts, hypogammaglobulinemia, infections, and myelokathexis syndrome. The company also develops mavorixafor that is in Phase 3 4WARD clinical trial to evaluate the efficacy, safety, and tolerability of oral, once-daily mavorixafor with or without stable doses of G-CSF in people with congenital, acquired primary autoimmune, or idiopathic CN who are experiencing recurrent and/or serious infections. It has a license agreement with Abbisko Therapeutics Co Ltd. to develop, manufacture, and commercialize mavorixafor in combination with checkpoint inhibitors or other agents in oncology indications; and with Norgine to develop, manufacture, and commercialize mavorixafor in Europe, Australia, and New Zealand. The company is headquartered in Boston, Massachusetts.

Fundamentals
Scroll to Statements
Sector Healthcare Industry Biotechnology Market Cap 296.41M
Enterprise Value 231.46M Income -95.09M Sales 33.98M
Book/sh 2.45 Cash/sh 1.40 Dividend Yield —
Payout 0.00% Employees 143 IPO —
P/E — Forward P/E -3.12 PEG —
P/S 8.72 P/B 1.38 P/C —
EV/EBITDA -2.56 EV/Sales 6.81 Quick Ratio 5.27
Current Ratio 5.65 Debt/Eq 125.54 LT Debt/Eq —
EPS (ttm) -8.92 EPS next Y -1.09 EPS Growth —
Revenue Growth 215.20% Earnings 2026-03-24 ROA -33.54%
ROE -156.87% ROIC — Gross Margin 83.24%
Oper. Margin -12.81% Profit Margin -279.86% Shs Outstand 87.44M
Shs Float 61.12M Short Float 3.57% Short Ratio 9.05
Short Interest — 52W High 14.70 52W Low 1.35
Beta 0.43 Avg Volume 602.99K Volume 220.75K
Target Price $9.33 Recom None Prev Close $3.16
Price $3.39 Change 7.28%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$9.33
Mean price target
2. Current target
$3.39
Latest analyst target
3. DCF / Fair value
$-13.98
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$3.39
Low
$5.00
High
$13.00
Mean
$9.33

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2025-12-05 main Stifel Buy → Buy $10
2025-11-10 main HC Wainwright & Co. Buy → Buy $5
2025-08-29 main Stifel Buy → Buy $9
2025-08-13 main HC Wainwright & Co. Buy → Buy $4
2025-05-02 main HC Wainwright & Co. Buy → Buy $7
2025-03-27 reit HC Wainwright & Co. Buy → Buy $2
2025-03-26 reit Cantor Fitzgerald Overweight → Overweight $3
2025-02-07 reit HC Wainwright & Co. Buy → Buy $2
2025-01-14 reit HC Wainwright & Co. Buy → Buy $2
2024-11-14 main HC Wainwright & Co. Buy → Buy $2
2024-11-14 main Stifel Buy → Buy $4
2024-06-28 reit HC Wainwright & Co. Buy → Buy $5
2024-05-31 reit Cantor Fitzgerald Overweight → Overweight $5
2024-04-30 main HC Wainwright & Co. Buy → Buy $5
2024-03-22 reit HC Wainwright & Co. Buy → Buy $3
2023-12-12 down B. Riley Securities Buy → Neutral $1
2023-08-11 reit HC Wainwright & Co. Buy → Buy $3
2023-05-17 main Stifel Buy → Buy $5
2023-05-05 reit HC Wainwright & Co. — → Buy $3
2023-04-10 main B. Riley Securities — → Buy $3
Insider Transactions
Date Shares Value Url Text Insider Position Transaction Start Date Ownership
0 86206 249997.0 — Purchase at price 2.90 per share. CRAIG ADAM R Officer and Director — 2025-10-23 00:00:00 D
1 289881 — — Stock Award(Grant) at price 0.00 per share. CRAIG ADAM R Officer and Director — 2025-08-14 00:00:00 D
2 193254 — — Stock Award(Grant) at price 0.00 per share. KIRSKE DAVID H. SR Chief Financial Officer — 2025-08-14 00:00:00 D
3 289881 — — Stock Award(Grant) at price 0.00 per share. VOLPONE JOHN President — 2025-08-14 00:00:00 D
4 1500 — — Stock Award(Grant) at price 0.00 per share. WYZGA MICHAEL S Director — 2025-06-09 00:00:00 D
5 1500 — — Stock Award(Grant) at price 0.00 per share. MCGIRR DAVID W J Director — 2025-06-09 00:00:00 D
6 1500 — — Stock Award(Grant) at price 0.00 per share. STEWART MURRAY Director — 2025-06-09 00:00:00 D
7 1500 — — Stock Award(Grant) at price 0.00 per share. BRIDGER GARY J Director — 2025-06-09 00:00:00 D
8 1500 — — Stock Award(Grant) at price 0.00 per share. DE CRAECKER FRANCOISE Director — 2025-06-09 00:00:00 D
9 1500 — — Stock Award(Grant) at price 0.00 per share. WOODS KEITH Director — 2025-06-09 00:00:00 D
Financials
Line Item2024-12-312023-12-312022-12-312021-12-31
TaxEffectOfUnusualItems22.45M1.49M464.10K-2.73M
TaxRateForCalcs0.210.210.210.27
NormalizedEBITDA-134.50M-101.97M-91.54M-74.41M
TotalUnusualItems106.93M7.07M2.21M-10.12M
TotalUnusualItemsExcludingGoodwill106.93M7.07M2.21M-10.12M
NetIncomeFromContinuingOperationNetMinorityInterest-37.45M-101.17M-93.87M-88.70M
ReconciledDepreciation796.00K419.00K513.00K499.00K
ReconciledCostOfRevenue797.00K0.000.00
EBITDA-27.58M-94.89M-89.33M-84.54M
EBIT-28.37M-95.31M-89.85M-85.04M
NetInterestIncome-3.00M-1.20M-3.77M-3.63M
InterestExpense8.77M5.78M3.99M3.64M
InterestIncome5.77M4.58M219.00K10.00K
NormalizedIncome-121.92M-106.76M-95.61M-81.31M
NetIncomeFromContinuingAndDiscontinuedOperation-37.45M-101.17M-93.87M-88.70M
TotalExpenses143.96M107.52M88.08M75.35M
TotalOperatingIncomeAsReported-36.40M-107.52M-87.57M-85.11M
DilutedAverageShares6.70M5.93M2.12M858.30K
BasicAverageShares6.70M5.93M2.12M858.30K
DilutedEPS-5.70-17.10-45.60-119.70
BasicEPS-5.70-17.10-45.60-119.70
DilutedNIAvailtoComStockholders-37.45M-101.17M-96.41M-102.64M
NetIncomeCommonStockholders-37.45M-101.17M-96.41M-102.64M
OtherunderPreferredStockDividend0.000.002.55M13.94M
NetIncome-37.45M-101.17M-93.87M-88.70M
NetIncomeIncludingNoncontrollingInterests-37.45M-101.17M-93.87M-88.70M
NetIncomeContinuousOperations-37.45M-101.17M-93.87M-88.70M
TaxProvision310.00K78.00K28.00K17.00K
PretaxIncome-37.14M-101.09M-93.84M-88.68M
OtherIncomeExpense107.26M7.63M-1.99M-9.70M
OtherNonOperatingIncomeExpenses332.00K554.00K-4.20M426.00K
SpecialIncomeCharges105.00M0.00509.00K-9.76M
GainOnSaleOfPPE105.00M0.00509.00K0.00
ImpairmentOfCapitalAssets0.000.009.76M
GainOnSaleOfSecurity1.93M7.07M1.70M-366.00K
NetNonOperatingInterestIncomeExpense-3.00M-1.20M-3.77M-3.63M
InterestExpenseNonOperating8.77M5.78M3.99M3.64M
InterestIncomeNonOperating5.77M4.58M219.00K10.00K
OperatingIncome-141.40M-107.52M-88.08M-75.35M
OperatingExpense143.16M107.52M88.08M75.35M
ResearchAndDevelopment81.64M72.02M61.06M50.65M
SellingGeneralAndAdministration61.52M35.51M27.02M24.70M
GeneralAndAdministrativeExpense24.70M
OtherGandA24.70M
GrossProfit1.76M0.000.00
CostOfRevenue797.00K0.000.00
TotalRevenue2.56M0.000.000.00
OperatingRevenue2.56M0.000.000.00
Line Item2024-12-312023-12-312022-12-312021-12-31
OrdinarySharesNumber5.70M5.58M4.06M937.59K
ShareIssued5.70M5.58M4.06M937.59K
NetDebt19.73M
TotalDebt78.09M58.28M38.42M39.78M
TangibleBookValue-5.20M33.75M56.70M47.06M
InvestedCapital97.57M105.67M107.67M98.35M
WorkingCapital79.30M99.21M106.35M73.86M
NetTangibleAssets-5.20M33.75M56.70M47.06M
CapitalLeaseObligations2.66M3.71M4.80M5.85M
CommonStockEquity22.15M51.10M74.05M64.41M
TotalCapitalization97.57M105.67M106.36M97.55M
TotalEquityGrossMinorityInterest22.15M51.10M74.05M64.41M
StockholdersEquity22.15M51.10M74.05M64.41M
GainsLossesNotAffectingRetainedEarnings-122.00K-119.00K-119.00K-119.00K
OtherEquityAdjustments-122.00K-119.00K-119.00K-119.00K
RetainedEarnings-515.36M-477.90M-376.74M-282.87M
AdditionalPaidInCapital537.46M528.96M450.79M347.37M
CapitalStock171.00K167.00K122.00K28.00K
CommonStock171.00K167.00K122.00K28.00K
PreferredStock0.000.00
TotalLiabilitiesNetMinorityInterest124.30M96.16M81.53M52.76M
TotalNonCurrentLiabilitiesNetMinorityInterest91.42M73.30M59.21M38.74M
OtherNonCurrentLiabilities831.00K432.00K173.00K826.00K
DerivativeProductLiabilities13.76M15.68M23.13M0.00
LongTermDebtAndCapitalLeaseObligation76.83M57.18M35.91M37.91M
LongTermCapitalLeaseObligation1.41M2.61M3.60M4.78M
LongTermDebt75.42M54.57M32.30M33.14M
CurrentLiabilities32.88M22.86M22.32M14.02M
CurrentDebtAndCapitalLeaseObligation1.25M1.10M2.51M1.87M
CurrentCapitalLeaseObligation1.25M1.10M1.20M1.07M
CurrentDebt1.31M795.00K
OtherCurrentBorrowings1.31M795.00K
PensionandOtherPostRetirementBenefitPlansCurrent13.05M8.20M6.59M5.42M
PayablesAndAccruedExpenses18.57M13.57M13.22M6.74M
CurrentAccruedExpenses9.95M4.62M5.44M2.45M
Payables8.62M8.95M7.78M4.28M
AccountsPayable8.62M8.95M7.78M4.28M
TotalAssets146.45M147.26M155.59M117.18M
TotalNonCurrentAssets34.27M25.18M26.91M29.30M
OtherNonCurrentAssets2.08M1.44M1.23M1.72M
GoodwillAndOtherIntangibleAssets27.35M17.35M17.35M17.35M
OtherIntangibleAssets10.00M
Goodwill17.35M17.35M17.35M17.35M
NetPPE4.84M6.39M8.33M10.22M
AccumulatedDepreciation-1.90M-1.62M-1.23M-724.00K
GrossPPE6.74M8.01M9.56M10.95M
Leases228.00K228.00K228.00K228.00K
OtherProperties4.73M6.30M7.87M9.29M
MachineryFurnitureEquipment1.78M1.49M1.47M1.43M
Properties0.000.000.000.00
CurrentAssets112.17M122.08M128.68M87.88M
OtherCurrentAssets5.59M7.30M5.81M5.34M
PrepaidAssets5.34M
Inventory2.82M0.00
FinishedGoods680.00K0.00
WorkInProcess608.00K0.00
RawMaterials1.53M0.00
Receivables1.71M562.00K1.15M747.00K
OtherReceivables640.00K562.00K1.15M747.00K
AccountsReceivable1.07M0.00
CashCashEquivalentsAndShortTermInvestments102.06M114.22M121.72M81.79M
OtherShortTermInvestments46.36M15.00M0.00
CashAndCashEquivalents55.70M99.22M121.72M81.79M
Line Item2024-12-312023-12-312022-12-312021-12-31
FreeCashFlow-138.23M-96.57M-77.20M-71.52M
RepurchaseOfCapitalStock0.000.00-2.00M
RepaymentOfDebt0.00-2.06M-795.00K0.00
IssuanceOfDebt20.00M22.50M0.000.00
IssuanceOfCapitalStock0.0060.00M122.63M75.98M
CapitalExpenditure-7.33M-60.00K-103.00K-615.00K
InterestPaidSupplementalData7.77M4.60M3.01M2.91M
EndCashPosition56.48M100.25M123.03M83.11M
BeginningCashPosition100.25M123.03M83.11M80.70M
EffectOfExchangeRateChanges-156.00K99.00K-105.00K-319.00K
ChangesInCash-43.62M-22.88M40.02M2.73M
FinancingCashFlow20.29M88.52M117.23M74.25M
CashFlowFromContinuingFinancingActivities20.29M88.52M117.23M74.25M
NetOtherFinancingCharges-631.00K-4.81M
ProceedsFromStockOptionExercised294.00K8.71M208.00K260.00K
NetCommonStockIssuance0.0060.00M122.63M73.98M
CommonStockPayments0.000.00-2.00M
CommonStockIssuance0.0060.00M122.63M75.98M
NetIssuancePaymentsOfDebt20.00M20.44M-795.00K0.00
NetLongTermDebtIssuance20.00M20.44M-795.00K0.00
LongTermDebtPayments0.00-2.06M-795.00K0.00
LongTermDebtIssuance20.00M22.50M0.000.00
InvestingCashFlow66.99M-14.88M-103.00K-615.00K
CashFlowFromContinuingInvestingActivities66.99M-14.88M-103.00K-615.00K
NetOtherInvestingChanges105.00M
NetInvestmentPurchaseAndSale-30.68M-14.82M0.000.00
SaleOfInvestment26.45M2.00M0.000.00
PurchaseOfInvestment-57.13M-16.82M0.000.00
NetIntangiblesPurchaseAndSale-7.00M0.000.00
PurchaseOfIntangibles-7.00M0.000.00
NetPPEPurchaseAndSale-326.00K-60.00K-103.00K-615.00K
PurchaseOfPPE-326.00K-60.00K-103.00K-615.00K
OperatingCashFlow-130.90M-96.51M-77.10M-70.91M
CashFlowFromContinuingOperatingActivities-130.90M-96.51M-77.10M-70.91M
ChangeInWorkingCapital2.67M344.00K5.74M-1.50M
ChangeInOtherCurrentLiabilities-1.00M-1.13M-882.00K-698.00K
ChangeInOtherCurrentAssets0.000.00-59.00K
ChangeInPayablesAndAccruedExpense6.88M2.84M7.23M1.01M
ChangeInAccruedExpense7.17M1.61M3.80M-152.00K
ChangeInPayable-286.00K1.23M3.42M1.17M
ChangeInAccountPayable-286.00K1.23M3.42M1.17M
ChangeInPrepaidAssets683.00K-1.37M-610.00K-1.75M
ChangeInInventory-2.82M0.000.00
ChangeInReceivables-1.07M0.000.00
ChangesInAccountReceivables-1.07M0.000.00
OtherNonCashItems1.80M2.28M2.44M2.49M
StockBasedCompensation8.20M8.69M5.20M6.18M
AssetImpairmentCharge0.000.009.76M
DepreciationAmortizationDepletion796.00K419.00K513.00K499.00K
DepreciationAndAmortization796.00K419.00K513.00K499.00K
OperatingGainsLosses-106.93M-7.07M2.88M366.00K
GainLossOnInvestmentSecurities-1.93M-7.07M2.88M366.00K
NetIncomeFromContinuingOperations-37.45M-101.17M-93.87M-88.70M
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

Public Trades for XFOR
Date User Asset Broker Type Position Size Entry Price Patterns